2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. FGL-1

FGL-1

Related Products

XLSX 4.27 KB

Subscribe Now to the List of Recombinant Proteins

Cat. No. Product Name / Synonyms Species Source
  • HY-P70737
    FGL1 Protein, Human (HEK293, His)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Human HEK293
    FGL1 protein, a major ligand for LAG3, suppresses antigen-specific T-cell activation, mediating LAG3's inhibitory function independently of MHC-II binding. Secreted by hepatocytes, FGL1 contributes to their growth. Existing as a homodimer, FGL1 interacts with LAG3 through its Fibrinogen C-terminal domain, specifically binding to LAG3's Ig-like domains 1 and 2. This interaction underscores FGL1's significance in modulating immune responses and hepatocyte growth, positioning it as a key regulator of T-cell activation and hepatic functions. FGL1 Protein, Human (HEK293, His) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGL1 Protein, Human (HEK293, His) is 290 a.a., with molecular weight of ~35.0 kDa.
  • HY-P70740
    FGL1 Protein, Human (HEK293, mFc)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Human HEK293
    FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, mFc) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGL1 Protein, Human (HEK293, mFc) is 290 a.a., with molecular weight of 60-65 kDa.
  • HY-P78589
    FGL1 Protein, Cynomolgus (HEK293, mFc)

    FGL1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1

    		Cynomolgus HEK293
    FGL1 Protein, a potent immune suppressive molecule, inhibits antigen-specific T-cell activation as a major ligand for LAG3. It crucially contributes to LAG3-mediated T-cell inhibitory functions, independently of MHC class II. Secreted by hepatocytes, FGL1 also promotes their growth. The homodimeric form of the protein interacts with LAG3, specifically engaging with its Ig-like domains 1 and 2 through the Fibrinogen C-terminal domain. FGL1 Protein, Cynomolgus (HEK293, mFc) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of FGL1 Protein, Cynomolgus (HEK293, mFc) is 290 a.a., with molecular weight of 60-66 kDa.
  • HY-P75189
    FGL1 Protein, Mouse (HEK293, hFc)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Mouse HEK293
    The FGL1 protein has signaling receptor binding activity and negatively regulates T cell activation and immune response. It is involved in adipose tissue development, cholesterol metabolism, and response to stilbenoid. FGL1 is located in the extracellular region and is orthologous to the human FGL1 gene. It is primarily expressed in the liver at the E18 stage. FGL1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived FGL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGL1 Protein, Mouse (HEK293, hFc) is 292 a.a., with molecular weight of ~60.08 kDa.
  • HY-P72369
    FGL1 Protein, Human (Biotinylated, 290a.a, HEK293, Avi-His)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Human HEK293
    FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, 290a.a, HEK293, Avi-His) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of FGL1 Protein, Human (Biotinylated, 290a.a, HEK293, Avi-His) is 290 a.a., with molecular weight of ~35 kDa.
  • HY-P78128
    FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, His-Avi)

    FGL1; FGL-1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1; Lag3 ligand

    		Human HEK293
    FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, His-Avi) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with N-Avi, N-His labeled tag. The total length of FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, His-Avi) is 242 a.a., with molecular weight of ~31.9 kDa.
  • HY-P78443
    FGL1 protein, Human (HEK293, His-Avi)

    FGL1; FGL-1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1; Lag3 ligand

    		Human HEK293
    FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 protein, Human (HEK293, His-Avi) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of FGL1 protein, Human (HEK293, His-Avi) is 242 a.a., with molecular weight of ~31.9 kDa.
  • HY-P701077
    FGL1 Protein, Human (Biotinylated, HEK293, hFc)

    FGL1; FGL-1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1; Lag3 ligand

    		Human HEK293
    FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, HEK293, hFc) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of FGL1 Protein, Human (Biotinylated, HEK293, hFc) is 242 a.a., with molecular weight of 60-66 kDa.
  • HY-P70740A
    FGL1 Protein, Human (HEK293, mFc, solution)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Human HEK293
    FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, mFc, solution) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGL1 Protein, Human (HEK293, mFc, solution) is 290 a.a., with molecular weight of 60-65 kDa.
  • HY-P72642
    FGL1 Protein, Cynomolgus (HEK293, His)

    Fibrinogen like 1; FGL1

    		Cynomolgus HEK293
    Fibrinogen like 1 (FGL1) is a proliferation- and metabolism-related protein secreted by the liver. FGL1 is also upregulated in tumor tissues. FGL1 is a checkpoint ligand of lymphocyte activation gene 3 (LAG3). When binding to LAG3, FGL1 can inhibit T cell activation and proliferation. FGL1 can be used for research of immune checkpoint therapy. FGL1 plays a role in proliferation, metabolism, apoptosis, epithelial-to-mesenchymal transition, and immune infiltration. FGL1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGL1 Protein, Cynomolgus (HEK293, His) is 290 a.a., with molecular weight of ~35 kDa.
  • HY-P75188
    FGL1 Protein, Mouse (sf9, His)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Mouse Sf9 insect cells
    FGL1 Protein, a potent immune suppressive molecule, inhibits antigen-specific T-cell activation as a major ligand for LAG3. It crucially contributes to LAG3-mediated T-cell inhibitory functions, independently of MHC class II. Secreted by hepatocytes, FGL1 also promotes their growth. The homodimeric form of the protein interacts with LAG3, specifically engaging with its Ig-like domains 1 and 2 through the Fibrinogen C-terminal domain. FGL1 Protein, Mouse (sf9, His) is the recombinant mouse-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FGL1 Protein, Mouse (sf9, His) is 314 a.a., with molecular weight of ~35.5 kDa.
  • HY-P75771
    FGL1 Protein, Rat (sf9, His)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Rat Sf9 insect cells
    The FGL1 protein is a key immunosuppressant that acts as the primary ligand of LAG3 to inhibit antigen-specific T cell activation. FGL1 is essential for the T cell suppressor function of LAG3, which is independent of MHC class II (MHC-II) binding. FGL1 is secreted by hepatocytes and actively promotes their growth. FGL1 Protein, Rat (sf9, His) is the recombinant rat-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FGL1 Protein, Rat (sf9, His) is 314 a.a., with molecular weight of ~35.48 kDa.
  • HY-P77366
    FGL1 Protein, Cynomolgus (HEK293, Fc)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Cynomolgus HEK293
    FGL1 is a specific hepatocyte mitogen, regulates the expression of proliferative factors, promoting liver regeneration and repairing liver injury. FGL1 inhibits T-cell activation by binding to LAG3. FGL1 promotes cell proliferation by activating the ERK/p-ERK pathway. FGL1 inhibits apoptosis of non-small cell lung cancer (NSCLC) cells by inhibiting PARP1/caspase 3 pathway. FGL1 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGL1 Protein, Cynomolgus (HEK293, Fc) is 312 a.a., with molecular weight of ~56.94 KDa.
  • HY-P77367
    FGL1 Protein, Cynomolgus (sf9, His)

    Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1

    		Cynomolgus Sf9 insect cells
    FGL1 is a specific hepatocyte mitogen, regulates the expression of proliferative factors, promoting liver regeneration and repairing liver injury. FGL1 inhibits T-cell activation by binding to LAG3. FGL1 promotes cell proliferation by activating the ERK/p-ERK pathway. FGL1 inhibits apoptosis of non-small cell lung cancer (NSCLC) cells by inhibiting PARP1/caspase 3 pathway. FGL1 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FGL1 Protein, Cynomolgus (sf9, His) is 312 a.a., with molecular weight of ~35.40 KDa.
Cat. No. Product Name Effect Purity