DENV E Proteins
The envelope protein (E) of dengue virus is the class II fusion glycoprotein that tiles the mature virion surface as flat, antiparallel homodimers forming a smooth herringbone lattice. Each subunit comprises three beta-strand domains, DI, DII, and DIII, followed by a stem and membrane anchor; DIII adopts an immunoglobulin-like fold implicated in receptor attachment, while DII bears the conserved fusion loop that inserts into endosomal membranes when acidic pH triggers refolding of the dimer into fusogenic trimers. As the principal antigen of dengue, E elicits the bulk of neutralizing antibodies, and antigenic differences among the four serotypes underlie antibody-dependent enhancement of secondary heterotypic infections. E is the immunogen in licensed tetravalent vaccines and the basis of serotype-specific diagnostics.
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DENV E Recombinant Proteins (9)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
