1. Membrane Transporter/Ion Channel
  2. Monoamine Transporter

Monoamine Transporter

Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Three major classes of MATs (SERT, DAT, NET) are responsible for the reuptake of their associated amine neurotransmitters (serotonin, dopamine, norepinephrine). MATs are located just outside the synaptic cleft (peri-synaptically), transporting monoamine transmitter overflow from the synaptic cleft back to the cytoplasm of the pre-synaptic neuron. MAT regulation generally occurs throughphosphorylation and posttranslational modification. Due to their significance in neuronal signaling, MATs are commonly associated with drugs used to treat mental disorders as well as recreational drugs. Compounds targeting MATs range from medications such as the wide variety of tricyclic antidepressants, selective serotonin reuptake inhibitors to stimulantmedications and amphetamine.

Monoamine Transporter Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-B1618
    Corticosterone Inhibitor 99.29%
    Corticosterone is a sensitive inhibitor of monoamine transport.
  • HY-N0480
    Reserpine Inhibitor 99.83%
    Reserpine (Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that irreversibly blocks the vesicular monoamine transporter (VMAT).
  • HY-B0590
    Tetrabenazine Inhibitor 99.10%
    Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.
  • HY-15793
    NBI-98782 Inhibitor
    NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.
  • HY-B0590B
    Tetrabenazine (+)- Inhibitor 99.81%
    Tetrabenazine ((+)-) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.
  • HY-B0590A
    Tetrabenazine Racemate Inhibitor >98.0%
    Tetrabenazine (Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2).
  • HY-N0480A
    Reserpine hydrochloride Inhibitor 99.84%
    Reserpine hydrochloride (Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that irreversibly blocks the vesicular monoamine transporter (VMAT).
  • HY-101416
    Vanilpyruvic acid >98.0%
    Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.
  • HY-B0590S
    Tetrabenazine D6 Inhibitor
    Tetrabenazine D6 is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.
  • HY-17590
    Radafaxine hydrochloride Inhibitor
    Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.
  • HY-15793A
    NBI-98854 Inhibitor
    NBI-98854 is a potent, highly selective, VMAT2 inhibitor that is effective in regulating the levels of dopamine release during nerve communication.