1. Membrane Transporter/Ion Channel
  2. Monoamine Transporter
  3. Valbenazine

Valbenazine (Synonyms: NBI-98854)

Cat. No.: HY-16771 Purity: 99.03%
Handling Instructions

Valbenazine is a prodrug of the (+)-α isomer of Ro 1-9569 for tardive syndrome therapy, and inhibits VMAT2 function.

For research use only. We do not sell to patients.

Valbenazine Chemical Structure

Valbenazine Chemical Structure

CAS No. : 1025504-45-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 155 In-stock
Estimated Time of Arrival: December 31
2 mg USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 168 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
25 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 780 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Valbenazine is a prodrug of the (+)-α isomer of Ro 1-9569 for tardive syndrome therapy, and inhibits VMAT2 function.

In Vivo

Valbenazine shows a distinctive improvement in tardive dyskinesia symptoms during the successful Phase II trial[1].

Clinical Trial
Molecular Weight

418.57

Formula

C₂₄H₃₈N₂O₄

CAS No.

1025504-45-3

SMILES

O=C([[email protected]@H](N)C(C)C)O[[email protected]@H]1C[[email protected]]2([H])C3=CC(OC)=C(OC)C=C3CCN2C[[email protected]]1CC(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (119.45 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3891 mL 11.9454 mL 23.8909 mL
5 mM 0.4778 mL 2.3891 mL 4.7782 mL
10 mM 0.2389 mL 1.1945 mL 2.3891 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.03%

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Valbenazine
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HY-16771
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