1. Membrane Transporter/Ion Channel
  2. Monoamine Transporter
  3. Valbenazine tosylate

Valbenazine tosylate  (Synonyms: NBI-98854 tosylate)

Cat. No.: HY-16771A
Handling Instructions

Valbenazine tosylate (NBI-98854 tosylate) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with the Ki of 110-190 nM.

For research use only. We do not sell to patients.

Valbenazine tosylate Chemical Structure

Valbenazine tosylate Chemical Structure

CAS No. : 1639208-54-0

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Description

Valbenazine tosylate (NBI-98854 tosylate) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with the Ki of 110-190 nM[1].

In Vitro

Valbenazine exhibits VMAT2 binding affinity in rat striatum and human platelets with Kis of 110 and 150 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Valbenazine (10 mg/kg; orally) induces ptosis (primarily an adrenergic response) and increases plasma prolactin primarily a dopaminergic response in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

762.97

Formula

C38H54N2O10S2

CAS No.
SMILES

O=C([C@@H](N)C(C)C)O[C@@H]1C[C@]2([H])C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC(C)C.O=S(C4=CC=C(C)C=C4)(O)=O.O=S(C5=CC=C(C)C=C5)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Valbenazine tosylate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Valbenazine tosylate
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HY-16771A
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