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Cat. No.: HY-16771B

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Valbenazine dihydrochloride

(Synonyms: NBI-98854 dihydrochloride)

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

Valbenazine (NBI-98854) dihydrochloride is a VMAT2 inhibitor, used to treat tardive dyskinesia. Valbenazine dihydrochloride demonstrates potential benefit in alleviating symptoms associated with movement disorders resulting from chronic dopamine receptor blocking medications. Valbenazine dihydrochloride has been supported by evidence from preclinical models examining its role in the genetic factors linked to tardive dyskinesia.

For research use only. We do not sell to patients.

CAS No.: 1639208-51-7
Formula: C₂₄H₄₀Cl₂N₂O₄
Molecular Weight:491.49

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Valbenazine dihydrochloride Chemical Structure

CAS No.: 1639208-51-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Dopamine Receptor Isoforms :

Chemical Information

CAS No. 1639208-51-7
Molecular Weight 491.49
Formula C₂₄H₄₀Cl₂N₂O₄
SMILES

CC(C)[C@H](N)C(O[C@@H]1C[C@]2([H])C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC(C)C)=O.Cl.Cl
Synonyms

NBI-98854 dihydrochloride
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Nat Commun

Drug inhibition and substrate transport mechanisms of human VMAT2. [Abstract]

2025 Jan 2;16(1):323. PMID: 39747030
Crit Rev Anal Chem

A Critical Review on Advancement in Analytical Strategies for the Quantification of Clinically Relevant Biological Transporters. [Abstract]

2022;52(7):1557-1571. PMID: 33691566
Bioorg Chem

Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]

2024 Jun:147:107412. PMID: 38696845
Sci Rep

Lactate reprograms PGE2 metabolism via GPR81 inhibits COX2 to relieved psoriasis. [Abstract]

2026 May 6;16(1):20905. PMID: 42092124
Toxicol Appl Pharmacol

Valbenazine promotes body growth via growth hormone signaling during zebrafish embryonic development. [Abstract]

2023 Oct 15:477:116674. PMID: 37648088

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Genetics of tardive dyskinesia: Promising leads and ways forward [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Valbenazine dihydrochloride

5 Cited Publications

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Publications (5)
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Valbenazine dihydrochloride

Publications Citing Use of MedChemExpress (MCE) Valbenazine dihydrochloride

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Publications (5)

Purity & Documentation

References

Calculators

Help & FAQs

Valbenazine dihydrochloride Related Classifications

HY-16771B Related Classifications