1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor

Dopamine Receptor

Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.

Dopamine Receptor Related Products (98):

Cat. No. Product Name Effect Purity
  • HY-15296
    Cabergoline Inhibitor
    Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).
  • HY-14538
    Haloperidol Antagonist
    Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
  • HY-14763
    Cariprazine Modulator
    Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
  • HY-14543
    Sertindole Antagonist
    Sertindole, a neuroleptic, is one of the newer antipsychotic medications available.
  • HY-75502
    Rotigotine Agonist
    Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively.
  • HY-B0032
    Lurasidone Hydrochloride Inhibitor
    Lurasidone Hcl (SM 13496 Hcl) is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.
  • HY-A0008
    B-HT 920 Agonist
    B-HT 920(Talipexole 2Hcl) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.
  • HY-14782
    Adoprazine Antagonist
    Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.
  • HY-15394
    rac-Rotigotine Hydrochloride Agonist
    rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.
  • HY-11018
    Risperidone Antagonist
    Risperidone(R 64 766) is a serotonin 5-HT2 receptor blocker(Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist(Ki= 1.4 nM).
  • HY-15238A
    ST-836 hydrochloride Agonist
    ST-836 Hcl is a dopamine receptor ligand; Antiparkinsonian agent.
  • HY-A0007
    Rotigotine Hydrochloride Agonist
    Rotigotine Hcl is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively.
  • HY-14545
    Amisulpride Antagonist
    Amisulpride(DAN 2163) is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor).
  • HY-17355
    Pramipexole dihydrochloride Agonist
    Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
  • HY-A0019
    Paliperidone Antagonist
    Paliperidone (9-hydroxyrisperidone is a dopamine antagonist of the atypical antipsychotic class of medications.
  • HY-17355A
    Dexpramipexole dihydrochloride Agonist
    Dexpramipexole 2Hcl(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist.
  • HY-17382
    Metoclopramide Antagonist
    Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic.
  • HY-17407
    Ziprasidone hydrochloride monohydrate Antagonist
    Ziprasidone(CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
  • HY-14348
    GSK163090 Antagonist
    GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3, respectively.
  • HY-14542
    Ziprasidone Antagonist
    Ziprasidone(CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.