Signaling Pathway

Dopamine Receptor

Dopamine Receptor

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Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.

Dopamine Receptor Inhibitors & Modulators (96)

Product Name Catalog No. Brief Description
(±)-Methotrimeprazine D6

HY-19489S

(±)-Methotrimeprazine (D6) is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.

(-)-Isocorypalmine

HY-N0927

(-)-Isocorypalmine is a metabolite of the isoquinoline alkaloid biosynthesis pathway.

Adoprazine

HY-14782

Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.

Amisulpride

HY-14545

Amisulpride(DAN 2163) is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor).

Amisulpride hydrochloride

HY-14545A

Amisulpride Hcl(DAN 2163 Hcl) is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor).

Amitifadine hydrochloride

HY-18332A

Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

Apomorphine hydrochloride hemihydrate

HY-12723A

Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.

Azaperone

HY-B1470

Azaperone acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties.

B-HT 920

HY-A0008

B-HT 920(Talipexole 2Hcl) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

Blonanserin

HY-13575

Blonanserin(AD-5423) is a D2/5-HT2 receptor antagonist, atypical antipsychotic.

Brexpiprazole

HY-15780

Brexpiprazole is a novel D2 dopamine partial agonist.

Bromocriptine mesylate

HY-12705A

Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

Bromopride

HY-B1164

Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic.

Cabergoline

HY-15296

Cabergoline, an ergot derivative, is a potent dopamine receptor agonist on D2 receptors.

Cariprazine

HY-14763

Cariprazine(RGH188) is a novel antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors.

Cariprazine hydrochloride

HY-14763A

Cariprazine Hcl(RGH188) is a novel antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors.

CGP 25454A

HY-100454

CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist.

Chlorpromazine D6 hydrochloride

HY-B0407AS

Chlorpromazine D6 hydrochloride is the deuterium labeled Chlorpromazine, which is a dopamine and potassium channel inhibitor

Chlorpromazine hydrochloride

HY-B0407A

Chlorpromazine Hydrochloride is a dopamine and potassium channel inhibitor used as the prototypical phenothiazine antipsychotic drug.

Chlorprothixene

HY-B0274

Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.