1. Neuronal Signaling
    GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Dopamine Receptor
    Endogenous Metabolite
  3. L-DOPA

L-DOPA (Synonyms: Levodopa; 3,4-Dihydroxyphenylalanine)

Cat. No.: HY-N0304 Purity: 99.97%
Handling Instructions

L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.

For research use only. We do not sell to patients.

L-DOPA Chemical Structure

L-DOPA Chemical Structure

CAS No. : 59-92-7

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Based on 1 publication(s) in Google Scholar

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Description

L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

L-DOPA (Levodopa; 20 mg/kg; oral) reduces Rotenone-induced motor dysfunction[3].
L-DOPA (Levodopa; 10, 30, 50, 70, and 100 mg/kg; oral) reverses tactile, cold and heat allodynia in neuropathic rat without any side effect in sprague-Dawley rats (male 100-150 g) [4].

Animal Model: 7-week-old C57BL/6J mice[3]
Dosage: 20 mg/kg
Administration: Oral
Result: Reduced Rotenone-induced motor dysfunction.
Clinical Trial
Molecular Weight

197.19

Formula

C₉H₁₁NO₄

CAS No.

59-92-7

SMILES

N[[email protected]@H](CC1=CC(O)=C(C=C1)O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 2 mg/mL (10.14 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0713 mL 25.3563 mL 50.7125 mL
5 mM 1.0143 mL 5.0713 mL 10.1425 mL
10 mM 0.5071 mL 2.5356 mL 5.0713 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

L-DOPALevodopa3,4-DihydroxyphenylalanineDopamine ReceptorEndogenous MetaboliteOrallyprecursorneurotransmittersdopamineblood-brainbarrieranti-allodynicParkinsonInhibitorinhibitorinhibit

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L-DOPA
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