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  4. L-DOPA sodium

L-DOPA sodium  (Synonyms: Levodopa sodium; 3,4-Dihydroxyphenylalanine sodium)

Cat. No.: HY-N0304A
Handling Instructions

L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research.

For research use only. We do not sell to patients.

L-DOPA sodium Chemical Structure

L-DOPA sodium Chemical Structure

CAS No. : 63302-01-2

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Description

L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

L-DOPA sodium (20 mg/kg; orally) reduces Rotenone-induced motor dysfunction[3].
L-DOPA sodium (0-100 mg/kg; orally) reverses tactile, cold and heat allodynia in neuropathic rat without any side effect in sprague-Dawley rats[4].In adult common marmosets (Callithrix jacchus, 2-3 years old, 270-350 g), L-DOPA (20/5 mg/kg, p.o.) shows the Tmax was 30 min in plasma and 60-90 min in extracellular fluid (ECF) of striatum. Mean Cmax was 20.3 μM in plasma and 442.9 nM in ECF of striatum, which is about 2.2% of that in plasma[6].
Induction of dyskinesia model[5]
Background
L-DOPA-induced dyskinesia results from a pulsatile stimulation of brain dopamine (DA) receptors, triggering a complex cascade of molecular and synaptic alterations within the basal ganglia[5].
Specific Mmodeling Methods
Mice: C57Bl/6 mice?•?male?• 8 weeks (period: 21 days)
Administration: 20 mg/kg?•?ip?•?once daily for 21 days
Note
(1) sustained unilateral 6-OHDA injections in the striatum before starting treatment.
(2) Injection volume is 10mL/kg body weight.


Modeling Indicators
Behavioral changes: Shows developed abnormal involuntary movements (AIMs) affecting the head, trunk and forelimb on the side contralateral to the lesion.
Correlated Product(s): Oxidopamine hydrochloride (HY-B1081)
Opposite Product(s): Oxidopamine hydrobromide (HY-B1081A)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (7-week-old)[3]
Dosage: 20 mg/kg
Administration: Orally
Result: Reduced Rotenone-induced motor dysfunction.
Animal Model: Sprague-Dawley rats[4]
Dosage: 10, 30, 50, 70, and 100 mg/kg
Administration: Orally
Result: Reverses tactile, cold and heat allodynia in neuropathic rat without any side effect.
Clinical Trial
Molecular Weight

219.17

Formula

C9H10NNaO4

CAS No.
SMILES

O=C([C@H](CC1=CC=C(C(O)=C1)O)N)O[Na]

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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L-DOPA sodium
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HY-N0304A
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