2. Induced Disease Models Products GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Nervous System Disease Models Dopamine Receptor Endogenous Metabolite
  4. Parkinson's Disease Models
  5. L-DOPA sodium

L-DOPA sodium  (Synonyms: Levodopa sodium; 3,4-Dihydroxyphenylalanine sodium)

Cat. No.: HY-N0304A Purity: 99.95%
COA
SDS
Handling Instructions Technical Support

L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research.

For research use only. We do not sell to patients.

CAS No. : 63302-01-2

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 35 publication(s) in Google Scholar

Other Forms of L-DOPA sodium:

L-DOPA sodium Related Antibodies

Top Publications Citing Use of Products

35 Publications Citing Use of MCE L-DOPA sodium

WB
In Vivo Efficacy Study
IHC

    L-DOPA sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr 13:e2413376.  [Abstract]

    Behavior analysis of pole test, rotarod test, suspension test, and forced swimming test after administration of L-DOPA, NanoMassage or saline. Mice were given an oral administration of 20 mg/kg L-DOPA on 4th day of MPTP administration and sacrificed on the 8th day.

    L-DOPA sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Aug 19:e2403058.  [Abstract]

    Movement track and total distance travelled in the open field test, descent time in the pole test and time-to-fall in the rotarod test. Mice in the treatment groups intragastrically (i.g.) administered 20 mg/kg/d L-DOPA for 27 days.

    L-DOPA sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Aug 19:e2403058.  [Abstract]

    Immunohistochemical staining of TH+ neurons. Mice in the treatment groups intragastrically (i.g.) administered 20 mg/kg/d L-DOPA for 27 days.

    L-DOPA sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Aug 19:e2403058.  [Abstract]

    Quantification of TH+ neurons. Mice in the treatment groups intragastrically (i.g.) administered 20 mg/kg/d L-DOPA for 27 days.

    L-DOPA sodium purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2023 Oct;29(10):2925-2939.  [Abstract]

    Amphiregulin (Areg) is highly expressed in the levodopa‐induced dyskinesia 6‐OHDA (4 μg; 4 weeks) Parkinson's disease mouse model. The Parkinson's disease group treated with a daily 12 mg/kg of levodopa for 15 days developed dyskinetic movement. On western blotting, this group further showed a significant increase of Amphiregulin protein expression relative to the Parkinson's disease group injected with normal saline only .

    View All Dopamine Receptor Isoform Specific Products:

    View All Isoforms
    Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    L-DOPA sodium can be used to create movement disorder models. In adult common marmosets, after oral administration of L-DOPA (20 mg/kg, 5 mg/kg) sodium, the Tmax in plasma is 30 minutes, and the Tmax in striatal extracellular fluid (ECF) is 60-90 minutes. The mean Cmax of L-DOPA sodium in plasma is 20.3 μM, while the mean Cmax in striatal ECF is 442.9 nM, representing about 2.2% of the plasma level[6].

    Induction of dyskinesia model[5]
    Background
    L-DOPA-induced dyskinesia results from a pulsatile stimulation of brain dopamine (DA) receptors, triggering a complex cascade of molecular and synaptic alterations within the basal ganglia[5].
    Specific Modeling Methods
    Mice: C57Bl/6 mice • male • 8 weeks (period: 21 days)
    Administration: 20 mg/kg • ip • once daily for 21 days
    Note
    (1) sustained unilateral 6-OHDA injections in the striatum before starting treatment.
    (2) Injection volume is 10mL/kg body weight.
    Modeling Indicators
    Behavioral changes: Shows developed abnormal involuntary movements (AIMs) affecting the head, trunk and forelimb on the side contralateral to the lesion.
    Correlated Product(s): Oxidopamine hydrochloride (HY-B1081)
    Opposite Product(s): Oxidopamine hydrobromide (HY-B1081A)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6J mice (7-week-old)[3]
    Dosage: 20 mg/kg
    Administration: Orally
    Result: Reduced Rotenone-induced motor dysfunction.
    Animal Model: Sprague-Dawley rats[4]
    Dosage: 10, 30, 50, 70, and 100 mg/kg
    Administration: Orally
    Result: Reverses tactile, cold and heat allodynia in neuropathic rat without any side effect.
    Clinical Trial
    Molecular Weight

    219.17

    Formula

    C9H10NNaO4
    CAS No.
    Appearance

    Solid

    Color

    Light brown to khaki

    SMILES

    O=C([C@H](CC1=CC=C(C(O)=C1)O)N)O[Na]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    L-DOPA sodium Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-DOPA63302-01-2Levodopa3,4-DihydroxyphenylalanineDopamine ReceptorEndogenous MetaboliteOrallyprecursorneurotransmittersdopamineblood-brainbarrieranti-allodynicParkinsonInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    L-DOPA sodium
    Cat. No.:
    HY-N0304A
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.