1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Dopamine Receptor
  4. Dopamine Receptor Inhibitors

Dopamine Receptor Inhibitors

Dopamine Receptor

D1 Receptor

D2 Receptor

D3 Receptor

D4 Receptor

D5 Receptor

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Dopamine Receptor Inhibitors, Agonists, Antagonists & Modulators
Product Name Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor Purity
SKF 81297  
D1 Receptor
        99.86%
SCH-23390 hydrochloride  
D1 Receptor, Ki: 0.2 nM
     
D5 Receptor, Ki: 0.3 nM
99.91%
Haloperidol    
D2 Receptor
      99.65%
SKF 38393 hydrochloride  
D1 Receptor
        99.44%
Cabergoline    
D2 Receptor
D3 Receptor
    99.86%
Clozapine    
D2 Receptor, Ki: 75 nM (Antagonist)
      99.97%
Risperidone    
D2 Receptor, Ki: 5.9 nM
      99.92%
Olanzapine
Dopamine Receptor
          99.83%
Aripiprazole    
D2 Receptor
D3 Receptor
D4 Receptor
  99.95%
Brexpiprazole    
D2L Receptor, Ki: 0.3 nM
      99.85%
Flunarizine dihydrochloride    
D2 Receptor
      99.87%
Sulpiride    
D2 Receptor
D3 Receptor
    99.75%
WAY-100635 maleate        
D4 Receptor
  99.89%
Lurasidone    
D2 Receptor, IC50: 1.68 nM
      99.90%
Nuciferine    
D2 Receptor, EC50: 64 nM
 
D4 Receptor, EC50: 2 μM
D5 Receptor, EC50: 2.6 μM
99.46%
Perphenazine    
D2 Receptor, Ki: 0.56 nM
D3 Receptor, Ki: 0.43 nM
D4 Receptor, Ki: 28.5 nM
  99.95%
Penfluridol    
D2 Receptor
      99.93%
Raclopride  
D1 Receptor, Ki: 18000 nM
D2 Receptor, Ki: 1.8 nM
D3 Receptor, Ki: 3.5 nM
D4 Receptor, Ki: 2400 nM
  99.72%
Ritanserin    
D2 Receptor, IC50: 70 nM
      99.78%
Paliperidone    
D2 Receptor
      99.69%
SKF-82958 hydrobromide  
D1 Receptor
        99.82%
WAY-100635        
D4 Receptor
  99.32%
Pramipexole    
D2 Receptor, Ki: 3.9 nM
D3 Receptor, Ki: 0.5 nM
D4 Receptor, Ki: 1.3 nM
  99.95%
Ziprasidone    
Rat D2 Receptor, Ki: 4.8 nM
      99.81%
Benztropine mesylate    
Human D2 Receptor
      99.92%
N-Methyldopamine hydrochloride  
D1 Receptor
        99.03%
Domperidone    
D2 Receptor
      99.79%
Pergolide mesylate  
D1 Receptor
D2 Receptor
      99.92%
Dihydrexidine hydrochloride  
D1 Receptor, IC50: 10 nM
        99.21%
Loxapine  
Human D1 Receptor
Human D2 Receptor
 
Human D4 Receptor
  99.69%
Cariprazine    
D2 Receptor, Ki: 0.49 nM
D3 Receptor, Ki: 0.085 nM
    99.83%
Ropinirole hydrochloride    
D2 Receptor, Ki: 29 nM
hD2 Receptor, pEC50: 7.4
hD3 Receptor, pEC50: 8.4
hD4.4 Receptor, pEC50: 6.8
  99.85%
Pramipexole dihydrochloride    
D2 Receptor
D3 Receptor
D4 Receptor
  ≥98.0%
Cariprazine hydrochloride    
D2 Receptor, Ki: 0.49 nM
D3 Receptor, Ki: 0.085 nM
    99.90%
Lurasidone Hydrochloride    
D2 Receptor, IC50: 1.68 nM
      99.96%
Sumanirole maleate    
D2 Receptor
      ≥99.0%
Piribedil    
D2 Receptor
D3 Receptor
    99.33%
Rotigotine  
D1 Receptor, Ki: 83 nM
D2 Receptor, Ki: 4-15 nM
D3 Receptor, Ki: 0.71 nM
D4 Receptor, Ki: 4-15 nM
D5 Receptor, Ki: 4-15 nM
99.98%
SKF-83566  
D1 Receptor
     
D5 Receptor
99.86%
Flupentixol dihydrochloride  
D1 Receptor
D2 Receptor
      99.73%
A68930 hydrochloride  
D1 Receptor
        ≥98.0%
PD-168077 maleate        
D4 Receptor
  98.74%
Paliperidone palmitate    
D2 Receptor
      98.41%
Loxapine succinate  
Human D1 Receptor
Human D2 Receptor
 
Human D4 Receptor
  99.81%
UNC9994 hydrochloride  
D1 Receptor, Ki: 4000 nM
D2 Receptor, Ki: 79 nM
D3 Receptor, Ki: 17 nM
D4 Receptor, Ki: 138 nM
  98.83%
Pridopidine    
D2 Receptor
      99.77%
Lumateperone tosylate  
D1 Receptor
D2 Receptor
      99.53%
Chlorprothixene  
Human D1 Receptor, Ki: 18 nM
Human D2 Receptor, Ki: 2.96 nM
Human D3 Receptor, Ki: 4.56 nM
 
Human D5 Receptor, Ki: 9 nM
99.61%
Chlorprothixene hydrochloride  
Human D1 Receptor, Ki: 18 nM
Human D2 Receptor, Ki: 2.96 nM
Human D3 Receptor, Ki: 4.56 nM
 
Human D5 Receptor, Ki: 9 nM
≥98.0%
Ansofaxine hydrochloride
Dopamine Receptor, IC50: 491 nM
          99.87%
SKF 81297 hydrobromide  
D1 Receptor
        ≥99.0%
Asenapine  
D1 Receptor, pKi: 8.9
D2 Receptor, pKi: 8.9
D3 Receptor, pKi: 9.4
D4 Receptor, pKi: 9.0
  99.93%
Ziprasidone hydrochloride monohydrate    
Rat D2 Receptor, Ki: 4.8 nM
      99.74%
SB-277011 hydrochloride      
D3 Receptor, Ki: 10.7-11.2 nM
    98.54%
Blonanserin  
D1 Receptor, Ki: 1070 nM
D2 Receptor, Ki: 0.142 nM
D3 Receptor, Ki: 0.494 nM
D4 Receptor, Ki: 150 nM
  99.62%
Rotigotine Hydrochloride  
D1 Receptor, Ki: 83 nM
D2 Receptor, Ki: 4-15 nM
D3 Receptor, Ki: 0.71 nM
D4 Receptor, Ki: 4-15 nM
D5 Receptor, Ki: 4-15 nM
99.65%
L-745870    
D2 Receptor, Ki: 960 nM
D3 Receptor, Ki: 2300 nM
Human D4 Receptor, Ki: 4.3 nM
  99.92%
Rotundine  
D1 Receptor, IC50: 166 nM
D2 Receptor, IC50: 1400 nM
D3 Receptor, IC50: 3300 nM
    99.87%
Itopride hydrochloride    
D2 Receptor
      99.85%
Ocaperidone    
D2 Receptor, Ki: 0.75 nM
      99.93%
Halopemide  
D1 Receptor
D2 Receptor
      99.65%
Tiapride hydrochloride    
D2 Receptor, IC50: 110-320 nM
D3 Receptor, IC50: 180 nM
    99.86%
Iloperidone  
Rat D1 Receptor, Ki: 546 nM
Human D1 Receptor, Ki: 216 nM
Rat D2 Receptor, Ki: 54 nM
Human D3 Receptor, Ki: 7.1 nM
Human D4 Receptor, Ki: 25 nM
Human D5 Receptor, Ki: 319 nM
99.97%
(Rac)-Tavapadon  
D1 Receptor
        99.87%
Pericyazine    
D2 Receptor
      99.96%
Xaliproden hydrochloride    
D2 Receptor, IC50: 0.1-1 μM
      98.57%
Thiethylperazine dimaleate    
D2 Receptor
      99.72%
Ecopipam hydrochloride  
D1 Receptor, Ki: 1.2 nM
D2 Receptor, Ki: 980 nM
 
D4 Receptor, Ki: 5520 nM
D5 Receptor, Ki: 2.0 nM
99.46%
Brilaroxazine    
D2 Receptor
D3 Receptor
D4 Receptor
  98.29%
Bromperidol    
D2 Receptor
      98.48%
Eticlopride hydrochloride    
D2 Receptor, Ki: 0.09 nM
      99.45%
Talipexole dihydrochloride    
D2 Receptor
      99.80%
SKF 83959  
D1 Receptor, Ki: 1.18 nM
D2 Receptor, Ki: 920 nM
D3 Receptor, Ki: 399 nM
 
D5 Receptor, Ki: 7.56 nM
98.93%
Ecopipam hydrobromide  
D1 Receptor, Ki: 1.2 nM
D2 Receptor, Ki: 980 nM
 
D4 Receptor, Ki: 5520 nM
D5 Receptor, Ki: 2.0 nM
≥99.0%
UNC9995    
D2 Receptor
      99.38%
Desmethyl cariprazine    
D2 Receptor, Ki: 0.49 nM
D3 Receptor, Ki: 0.085 nM
    98.06%
SKF 83959 hydrobromide  
D1 Receptor, Ki: 1.18 nM
D2 Receptor, Ki: 920 nM
D3 Receptor, Ki: 399 nM
 
D5 Receptor, Ki: 7.56 nM
99.86%
PF-06256142  
Human D1 Receptor, EC50: 33 nM
        98.70%
GSK163090    
D2 Receptor, pKi: 6.3
D3 Receptor, pKi: 6.7
    99.77%
Neuromedin N    
D2 Receptor
      99.61%
NGB 2904      
D3 Receptor, Ki: 1.4 nM
    ≥98.0%
Brexpiprazole S-oxide-d8    
D2 Receptor, Ki: 0.3 nM
      98.72%
Propionylpromazine hydrochloride    
D2 Receptor
     
Quinelorane dihydrochloride    
D2 Receptor
D3 Receptor
    ≥99.0%
SKF 83822  
Rat D1 Receptor
        98.66%
(Rac)-PF-06256142  
Human D1 Receptor, EC50: 107 nM
        99.31%
Fananserin        
D4 Receptor, Ki: 2.93 nM
  99.97%
Acetophenazine dimaleate    
D2 Receptor
      99.95%
Didesmethyl cariprazine    
D2 Receptor
D3 Receptor
    99.79%
L-745870 hydrochloride    
D2 Receptor, Ki: 960 nM
D3 Receptor, Ki: 2300 mM
Human D4 Receptor, Ki: 4.3 nM
  99.91%
Adoprazine    
D2 Receptor, pA2: 9.3
D2 Receptor, pKi: 8.4
D3 Receptor, pA2: 8.9
D3 Receptor, pKi: 8.4
D4 Receptor, pKi: 8.0
  98.60%
ML417      
D3 Receptor, EC50: 38 nM
    99.50%
CY 208-243  
D1 Receptor
        99.98%
Perospirone hydrochloride  
D1 Receptor, Ki: 41 nM
D2 Receptor, Ki: 1.4 nM
      99.94%
ABT-724 trihydrochloride        
D4 Receptor
  99.05%
(Rac)-Levomepromazine-d3 hydrochloride      
D3 Receptor
   
Risperidone-d4    
D2 Receptor
      99.40%
SKF-83566 hydrobromide  
D1 Receptor
     
D5 Receptor
Zuclopenthixol dihydrochloride    
D2 Receptor
      99.98%
Haloperidol-d4    
D2 Receptor
     
Cariprazine-d8      
D3 Receptor
    99.51%
(-)-GSK598809 hydrochloride      
D3 Receptor
    99.64%
S-14506 hydrochloride    
D2 Receptor
      99.92%
Olanzapine-d3      
D3 Receptor
    99.09%
(S)-Amisulpride    
D2 Receptor
D3 Receptor
    99.75%
Naxagolide    
D2 Receptor
      99.81%
SKF-75670 hydrobromide  
D1 Receptor
        99.83%
cis-(Z)-Flupentixol dihydrochloride    
D2 Receptor, Ki: 0.38 nM
     
SB-277011 dihydrochloride      
D3 Receptor
   
ST-836 hydrochloride    
D2 Receptor, Ki: 132 nM
D3 Receptor, Ki: 4.5 nM
    98.11%
Risperidone hydrochloride    
D2 Receptor, Ki: 5.9 nM
     
(Rac)-Rotigotine hydrochloride  
D1 Receptor, Ki: 83 nM
D2 Receptor, Ki: 13.5 nM
D3 Receptor, Ki: 0.71 nM
D4 Receptor, Ki: 3.9-15 nM
D5 Receptor, Ki: 5.4 nM
98.66%
Pardoprunox hydrochloride    
D2 Receptor, pEC50: 8
D3 Receptor, pEC50: 9.2
    98.24%
Ziprasidone hydrochloride    
Rat D2 Receptor, Ki: 4.8 nM
     
5-HT6/7 antagonist 1    
D2 Receptor
     
L-DOPA-2,5,6-d3      
D3 Receptor
    99.95%
Propionylpromazine-d6 hydrochloride    
D2 Receptor
      99.78%
Blonanserin dihydrochloride  
D1 Receptor, Ki: 1070 nM
D2 Receptor, Ki: 0.142 nM
D3 Receptor, Ki: 0.494 nM
D4 Receptor, Ki: 150 nM
 
Mesdopetam      
D3 Receptor
   
Amisulpride-d5      
D3 Receptor
    98.83%
Amisulpride-d5 N-Oxide      
D3 Receptor
   
Paliperidone-d4    
D2 Receptor
     
Iloperidone-d3      
D3 Receptor
   
Cabergoline-d5    
D2 Receptor
D3 Receptor
   
Dopamine D3 receptor ligand-3    
D2 Receptor, Ki: 353 nM
D3 Receptor, Ki: 3.6 nM
   
PD 168568 dihydrochloride    
D2 Receptor, Ki: 1842 nM
D3 Receptor, Ki: 2682 nM
D4 Receptor, Ki: 8.8 nM
 
Aripiprazole monohydrate    
D2 Receptor
D3 Receptor
D4 Receptor
 
PNU-177864 hydrochloride      
D3 Receptor
   
Pramipexole-d7 dihydrochloride    
D2 Receptor
D3 Receptor
D4 Receptor
 
Risperidone-d6    
D2 Receptor, Ki: 5.9 nM
     
SK609 hydrochloride      
Dopamine D3 receptor, EC50: 1109 nM
   
Dopamine D3 receptor ligand-1    
D2 Receptor, Ki: 715 nM
D3 Receptor, Ki: 8 nM
   
Blonanserin-d5    
D2 Receptor
     
Levosulpiride-d3      
D3 Receptor
    99.79%
A68930  
D1 Receptor
       
BP 897    
D2 Receptor
D3 Receptor
   
Tau-aggregation-IN-1    
D2 Receptor
D3 Receptor
   
PNU-96415E        
D4 Receptor
 
Brexpiprazole hydrochloride    
D2L Receptor, Ki: 0.3 nM
     
FAUC 213    
hD2 Receptor, Ki: 3.4 μM
hD3 Receptor, Ki: 5.3 μM
hD4.4 Receptor, Ki: 2.2 nM
  99.86%
SV 156    
Human D2 Receptor, Ki: 2.5 ± 0.4 nM
Human D3 Receptor, Ki: 96.9 ± 4.3 nM
Human D4 Receptor, Ki: 700 ± 56 nM
 
Pergolide-d7 mesylate    
D2 Receptor
     
BP 897 hydrochloride    
D2 Receptor
D3 Receptor
    99.84%
FAUC 346      
D3 Receptor, EC50: 1.5 nM
    99.90%
Lisuride    
D2 Receptor
     
Blonanserin-d8    
D2 Receptor
     
SCH-23390 maleate  
D1 Receptor, Ki: 0.2 nM
     
D5 Receptor, Ki: 0.3 nM
(-)-GSK598809      
D3 Receptor
   
Raclopride tartrate  
D1 Receptor, Ki: 18000 nM
D2 Receptor, Ki: 1.8 nM
D3 Receptor, Ki: 3.5 nM
D4 Receptor, Ki: 2400 nM
 
Dopamine D3 receptor ligand-4    
D2 Receptor, Ki: 7.43 nM
D3 Receptor, Ki: 0.5 nM
   
PD 119819
Dopamine Receptor
         
Benztropine-13C,d3 mesylate    
D2 Receptor
D3 Receptor
   
Ecopipam  
D1 Receptor, Ki: 1.2 nM
D2 Receptor, Ki: 980 nM
 
D4 Receptor, Ki: 5520 nM
D5 Receptor, Ki: 2.0 nM
Cinitapride monotartrate    
D2 Receptor
     
Asimilobine
Dopamine Receptor
         
Mesulergine hydrochloride
Dopamine Receptor
         
DETQ  
Human D1 Receptor, EC50: 5.8 nM
       
Bifeprunox    
D2 Receptor, pKi: 8.83 (striatum)
     
Razpipadon  
D1 Receptor
       
Alizapride-13C,d3 hydrochloride      
D3 Receptor
   
Piribedil hydrochloride    
D2 Receptor
D3 Receptor
   
Pramipexole-d5 dihydrochloride    
D2 Receptor
D3 Receptor
D4 Receptor
 
Ziprasidone mesylate trihydrate    
Rat D2 Receptor, Ki: 4.8 nM
     
Cyclo(glycyl-L-leucyl)
Dopamine Receptor
         
Ropinirole    
D2 Receptor, Ki: 29 nM
hD2 Receptor, pEC50: 7.4
hD3 Receptor, pEC50: 8.4
hD4.4 Receptor, pEC50: 6.8
 
Asenapine citrate  
D1 Receptor, pKi: 8.9
D2 Receptor, pKi: 8.9
D3 Receptor, pKi: 9.4
D4 Receptor, pKi: 9.0
 
Dopamine D4 receptor ligand 2    
D2 Receptor, IC50: >1000 nM
 
D4 Receptor, IC50: 0.057 nM
 
Dopamine D3 receptor antagonist-2      
D3 Receptor, Ki: 2.16 nM
   
Bromperidol hydrochloride    
D2 Receptor
      99.96%
Loxapine hydrochloride  
Human D1 Receptor
Human D2 Receptor
 
Human D4 Receptor
 
Dopamine D4 receptor antagonist-1        
hD4.2 Receptor, Ki: 9.0 nM
 
PG01037 dihydrochloride      
D3 Receptor, Ki: 0.7 nM
   
Asenapine-13C,d3 hydrochloride      
D3 Receptor
D4 Receptor
 
NGB 2904 hydrochloride      
D3 Receptor, Ki: 1.4
   
Dopamine D3 receptor ligand-2    
D2 Receptor, Ki: 1228 nM
D3 Receptor, Ki: 11.4 nM
   
Agroclavine  
D1 Receptor
       
BGC20-761    
Human D2 Receptor, Ki: 140 nM
     
D4R antagonis-2        
D4 Receptor, IC50: 6.87 μM
 
SKF 38393 hydrobromide  
D1 Receptor, IC50: 110 nM
       
Itopride    
D2 Receptor
     
Haloperidol-13C6    
D2 Receptor
     
Antipsychotic agent-2    
D2 Receptor, Kb: 45.7 nM
     
PD 168568    
D2 Receptor, Ki: 1842 nM
D3 Receptor, Ki: 2682 nM
D4 Receptor, Ki: 8.8 nM
 
Ziprasidone mesylate    
Rat D2 Receptor, Ki: 4.8 nM
     
NEO 376
Dopamine Receptor
          99.23%
D3R ligand 1      
D3 Receptor, Ki: 66 nM
   
Nemonapride    
D2 Receptor, Ki: 0.06 nM
     
A-77636  
Dopamine D1 receptor, EC50: 1.1 nM
Dopamine D1 receptor, Ki: 39.8 nM
       
Perphenazine dihydrochloride    
D2 Receptor, Ki: 0.56 nM
D3 Receptor, Ki: 0.43 nM
D4 Receptor, Ki: 28.5 nM
 
Cabergoline-d6    
D2 Receptor
D3 Receptor
   
PAOPA    
D2 Receptor
     
(Rac)-Rotigotine-d7 hydrochloride  
D1 Receptor
 
D3 Receptor
D4 Receptor
 
Acetophenazine    
D2 Receptor
     
LE 300  
Human D1 Receptor, Ki: 1.9 nM
     
Human D5 Receptor, Ki: 7.5 nM
OS-3-106      
D3 Receptor, Ki: 0.2 nM
   
SKF83822 hydrobromide  
D1 Receptor
       
FGH31        
Dopamine D4 receptor, Ki: 1.6 nM
 
UNC9994    
D2 Receptor, Ki: 79 nM
D3 Receptor, Ki: 17 nM
D4 Receptor, Ki: 138 nM
 
Sonepiprazole    
rD2 Receptor, Ki: 5147 nM
 
rD4 Receptor, Ki: 3.6 nM
hD4.2 Receptor, Ki: 10.1 nM
  99.84%
Haloperidol-d4-1    
D2 Receptor
      ≥98.0%
MOR agonist-2      
D3 Receptor
   
D4R antagonist-1        
D4 Receptor, IC50: 6.87 μM
 
Brexpiprazole S-oxide    
D2 Receptor, Ki: 0.3 nM
     
Itopride-d6 hydrochloride    
D2 Receptor
     
Fluphenazine decanoate dihydrochloride    
D2 Receptor
     
Risperidone mesylate    
D2 Receptor, Ki: 5.9 nM
     
Dexpramipexole-d3 dihydrochloride      
D3 Receptor
   
Pimozide-d5 N-Oxide  
D1 Receptor
 
D3 Receptor
   
Iloperidone hydrochloride  
Rat D1 Receptor, Ki: 546 nM
Human D1 Receptor, Ki: 216 nM
Rat D2 Receptor, Ki: 54 nM
Human D3 Receptor, Ki: 7.1 nM
Human D4 Receptor, Ki: 25 nM
Human D5 Receptor, Ki: 319 nM
Haloperidol-d4 N-Oxide    
D2 Receptor
     
Sumanirole    
D2 Receptor
     
Pardoprunox    
D2 Receptor, pEC50: 8
D3 Receptor, pEC50: 9.2
   
Raclopride-d5 hydrochloride      
D3 Receptor
    99.82%
Abaperidone    
D2 Receptor, IC50: 17 nM