CD37/Tspan-26
CD37, also called Tspan-26, is a four-pass transmembrane tetraspanin expressed most prominently on mature B cells, with weaker presence on T cells, myeloid cells and other leukocytes. Within tetraspanin-enriched microdomains it organizes membrane partners, including MHC class II molecules and integrins, and its cytoplasmic C-terminus modulates B-cell receptor and Toll-like receptor signaling. CD37-deficient mice and rare human cases reveal impaired humoral immunity, indicating a positive role in adaptive B-cell responses. Because expression is dense and B-cell restricted, CD37 is exploited as a target for antibody-drug conjugates such as naratuximab in lymphoma clinical trials.
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CD37/Tspan-26 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
