LY9/CD229
LY9, designated CD229, is a member of the SLAM family of immune receptors that carries two extracellular Ig-like domains and a long cytoplasmic tail bearing multiple tyrosine-based motifs. Homophilic interactions between CD229 molecules on T and B cells recruit SAP and EAT-2 adaptors, channeling signals that tune lymphocyte activation and cytokine output. The receptor is broadly expressed on T cells, B cells, NK cells, and dendritic cells throughout lymphoid tissues. Its cytoplasmic tail is notable for containing six tyrosine residues, reflecting strong adaptor-dependent regulation. Dysregulated CD229 signaling has been linked to lupus-like autoimmunity in mouse models, and the receptor serves as a B cell and plasma cell marker. Recombinant LY9/CD229 supports signaling and binding studies.
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LY9/CD229 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
