CD229/SLAMF3 Protein, Human (HEK293, His-Avi)

CD229/SLAMF3 Protein is a self-ligand receptor that belongs to the signaling lymphocytic activation molecule (SLAM) family. It functions as a modulator of immune cell activation and differentiation through homo- or heterotypic cell-cell interactions. This receptor plays a crucial role in regulating both innate and adaptive immune responses. The presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, controls its activities. CD229/SLAMF3 is involved in adhesion reactions between T lymphocytes and accessory cells through homophilic interactions. It promotes the differentiation of T-cells into a helper T-cell Th17 phenotype, leading to increased secretion of IL-17, with the costimulatory activity requiring SH2D1A. Furthermore, it facilitates the recruitment of RORC to the IL-17 promoter. CD229/SLAMF3 may also function as a negative regulator of the immune response, contributing to the maintenance of peripheral cell tolerance. It can inhibit autoantibody responses and IFN-gamma secretion by CD4(+) T-cells. Additionally, it is involved in regulating the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. CD229/SLAMF3 interacts with SH2D1A, SH2D1B, INPP5D, and PTPN11, with the interaction with PTPN11 being blocked by SH2D1A.