LY9 - lymphocyte antigen 9 Gene

Homo sapiens

Also known as hly9; mLY9; CD229; SLAMF3

Gene ID: 4063 | Gene type: protein coding

About LY9

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,796,174-160,828,255 (from NCBI)

This gene has 11 transcripts (splice variants), 132 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 6.9), spleen (RPKM 5.2) and 11 other tissues.

Summary

LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008]

LY9 Products(4)

mRNA	Protein	Name
NM_001033667.3	NP_001028839.1	T-lymphocyte surface antigen Ly-9 isoform b
NM_001261456.2	NP_001248385.1	T-lymphocyte surface antigen Ly-9 isoform c
NM_001261457.2	NP_001248386.1	T-lymphocyte surface antigen Ly-9 isoform d precursor
NM_002348.4	NP_002339.2	T-lymphocyte surface antigen Ly-9 isoform a precursor

LY9 Protein Structure

Ig_3

0
200
400
600
655 a.a.

Protein Preferred Names

Protein Names

T-lymphocyte surface antigen Ly-9

SLAM family member 3

Recombinant LY9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72465	CD229/SLAMF3 Protein, Human (HEK293, His)	Q9HBG7 (K48-K454)	≥95%
HY-P78487	CD229/SLAMF3 Protein, Human (HEK293, His-Avi)	Q9HBG7 (K48-K454)	≥95%
HY-P700672	CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9HBG7-1 (K48-K454)	≥95%

Related Diseases

Diseases

Alias

Multisystem Inflammatory Syndrome In Children

Mis-C	Multisystem Inflammatory Disorder In Children And Adolescents
Paediatric Inflammatory Multisystemic Syndrome	Mic

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Salpingo-Oophoritis

Tubo-Ovarian Inflammatory Disease	Salpingitis/Oophoritis
Suppurative Salpingo Oophoritis	Tubo-Ovarian Inflammation
Tubo-Ovarian Inflammatory Disorder	Purulent Salpingo Oophoritis
Septic Salpingo Oophoritis	Salpingo-Ovaritis
Inflammation Oviduct	Ruptured Salpingo Oophoritis
Pyosalpinx Rupture

Selective Immunoglobulin Deficiency Disease

Dysgammaglobulinemia

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis	Duncan Disease
Purtilo Syndrome	X-Linked Lymphoproliferative Syndrome
Xlp	X-Linked Lymphoproliferative Disease
XLP1	Lyp
Lymphoproliferative Disease, X-Linked	Xlpd
X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency	Ebv Infection, Severe, Susceptibility To
Ebvs	Immunodeficiency 5
Imd5	X-Linked Lymphoproliferative Syndrome 1
Epstein-Barr Virus Infection, Familial Fatal	Ebv Infection, Severe
Infectious Mononucleosis, Severe	Infectious Mononucleosis, Severe, Susceptibility To
Immunodeficiency, X-Linked Progressive Combined Variable	Epstein Barr Virus Infection, Familial Fatal
X-Linked Progressive Combined Variable Immunodeficiency 5	Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males
Familial Fatal Epstein-Barr Infection	Severe Susceptibility To Ebv Infection
Severe Susceptibility To Infectious Mononucleosis	Sap Deficiency
Sh2d1a/Slam-Associated Protein Deficiency	X-Linked Lymphoproliferative Syndrome Type 1
X-Linked Progressive Combined Variable Immunodeficiency	Lymphoproliferative Syndrome, X-Linked
Sap	X-Linked Lymphoproliferative Disorder

Smoldering Myeloma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07907	LY9 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LY9	VGNC	VGNC:68111
Canis familiaris	LY9	VGNC	VGNC:42877
Rattus norvegicus	LY9	RGD	RGD:1308341
Mus musculus	LY9	MGD	MGI:96885
Bos taurus	LY9	VGNC	VGNC:31094
Macaca fascicularis	LY9	NCBI
Macaca mulatta	LY9	NCBI
Others	LY9	NCBI