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LY9 - lymphocyte antigen 9 Gene

Also Known as hly9; mLY9; CD229; SLAMF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4063

About LY9

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,796,174-160,828,255 (from NCBI)

This gene has 11 transcripts (splice variants), 132 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 6.9), spleen (RPKM 5.2) and 11 other tissues.

Summary

LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008]

LY9 Products (4)

mRNA	Protein	Name
NM_001033667.3	NP_001028839.1	T-lymphocyte surface antigen Ly-9 isoform b
NM_001261456.2	NP_001248385.1	T-lymphocyte surface antigen Ly-9 isoform c
NM_001261457.2	NP_001248386.1	T-lymphocyte surface antigen Ly-9 isoform d precursor
NM_002348.4	NP_002339.2	T-lymphocyte surface antigen Ly-9 isoform a precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 17 cell lineage commitment	IDA IDA: Inferred from direct assay	22184727	GOA
involved in positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	22184727	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22184727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LY9 Protein Structure

Ig_3

0
200
400
600
655 a.a.

Protein Preferred Names	Protein Names
T-lymphocyte surface antigen Ly-9	SLAM family member 3

Recombinant LY9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72465	CD229/SLAMF3 Protein, Human (HEK293, His)	Q9HBG7-1 (K48-K454)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78487	CD229/SLAMF3 Protein, Human (HEK293, His-Avi)	Q9HBG7-1 (K48-K454)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700672	CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9HBG7-1 (K48-K454)	≥ 95%, as determined by reducing SDS-PAGE.

LY9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83034	CD229 Antibody (YA2779)	WB	Human
HY-P83034A	CD229 Antibody (YA2779)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Multisystem Inflammatory Syndrome In Children	Mis-C Multisystem Inflammatory Disorder In Children And Adolescents Paediatric Inflammatory Multisystemic Syndrome Mic
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Salpingo-Oophoritis	Tubo-Ovarian Inflammatory Disease Salpingitis/Oophoritis Suppurative Salpingo Oophoritis Tubo-Ovarian Inflammation Tubo-Ovarian Inflammatory Disorder Purulent Salpingo Oophoritis Septic Salpingo Oophoritis Salpingo-Ovaritis Inflammation Oviduct Ruptured Salpingo Oophoritis Pyosalpinx Rupture
Selective Immunoglobulin Deficiency Disease
Dysgammaglobulinemia
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp X-Linked Lymphoproliferative Disease XLP1 Lyp Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Smoldering Myeloma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07907	LY9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19563	Ly9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26059	Ly9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LY9	VGNC	VGNC:68111
Canis familiaris	LY9	VGNC	VGNC:42877
Rattus norvegicus	LY9	RGD	RGD:1308341
Mus musculus	LY9	MGD	MGI:96885
Bos taurus	LY9	VGNC	VGNC:31094
Others	LY9	NCBI