CD229 Antibody (YA2779)(PBS only)
(Synonyms: hly9; mLY9; CD229; SLAMF3)CD229 Antibody (YA2779) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD229.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
CD229 Antibody (YA2779) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD229.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 72 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 72 kDa
Recombinant protein of human CD229: aa48-454.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD229 is a Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity)[1][2].
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Subcellular Localization
Membrane; Cell membrane
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Expression
Tissue_Specificity: Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients. -
Isoforms & Post-Translational Modification
CD229 has 4 isoforms, Q9HBG7-1: amino acid length is 655, molecular weight is 72139 Da (predicted); Q9HBG7-2: amino acid length is 641, molecular weight is 70655 Da (predicted); Q9HBG7-3: amino acid length is 521, molecular weight is 57320 Da (predicted); Q9HBG7-4: amino acid length is 655, molecular weight is 71961 Da (predicted).
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Subunit
Interacts with SH2D1A, SH2D1B and INPP5D.
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SwissProt ID
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Synonyms
hly9; mLY9; CD229; SLAMF3
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Research Field
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Documentation
References
[1]. Chatterjee M, et al. Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. J Immunol. 2012 Feb 1;188(3):1206-12. [Content Brief]
[2]. Chatterjee M, et al. CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes. J Biol Chem. 2012 Nov 2;287(45):38168-77. [Content Brief]
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