CD229/SLAMF3 Protein, Mouse (HEK293, His)

The CD229/SLAMF3 protein serves as a self-ligand receptor within the signaling lymphocytic activation molecule (SLAM) family, influencing immune cell activation and differentiation through homo- or heterotypic cell-cell interactions. These interactions, regulated by the presence or absence of cytoplasmic adapter proteins such as SH2D1A/SAP and/or SH2D1B/EAT-2, play a crucial role in coordinating both innate and adaptive immune responses. CD229's involvement extends to adhesion reactions between T lymphocytes and accessory cells via homophilic interaction. Additionally, it contributes to T-cell differentiation, promoting a Th17 phenotype with increased IL-17 secretion, a process dependent on the presence of SH2D1A. CD229 also plays a role in maintaining peripheral cell tolerance by acting as a negative regulator of the immune response, potentially disabling autoantibody responses and inhibiting IFN-gamma secretion by CD4(+) T-cells. Moreover, it may negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. Furthermore, CD229 can enhance natural killer (NK) cell activation, and it interacts with SH2D1A, INPP5D, and PTPN11, with the latter interaction being blocked by SH2D1A.