2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Dopamine Receptor
  5. D4 Receptor Isoform

D4 Receptor

 

D4 Receptor Related Products (44):

Cat. No. Product Name Effect Purity
  • HY-14546
    Aripiprazole
    		Agonist 99.93%
    Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist.
  • HY-N0049
    Nuciferine
    		Agonist 99.46%
    Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
  • HY-B0410
    Pramipexole
    		Agonist 99.95%
    Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively.
  • HY-A0077
    Perphenazine
    		Antagonist 99.72%
    Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively.
  • HY-103414
    Raclopride
    		Antagonist 99.72%
    Raclopride is a dopamine D2/D3 receptor antagonist with potential antipsychotic effects.
  • HY-103407
    PD 168568
    		Antagonist
    PD 168568 is a orally active and potent dopamine receptor D4 (DRD4) antagonist.
  • HY-B0623A
    Ropinirole hydrochloride
    		Agonist 99.85%
    Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor.
  • HY-17390
    Loxapine
    		Inhibitor 99.69%
    Loxapine is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
  • HY-75502
    Rotigotine
    		Agonist 99.98%
    Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor.
  • HY-14325B
    L-745870 hydrochloride
    		Antagonist 99.91%
    L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM.
  • HY-10121
    Asenapine
    		Antagonist 99.93%
    Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0).
  • HY-A0007
    Rotigotine Hydrochloride
    		Agonist 99.65%
    Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
  • HY-13575
    Blonanserin
    		Antagonist 98.73%
    Blonanserin (AD-5423) is a potent and orally active 5-HT2A (Ki=0.812 nM) and dopamine D2 receptor (Ki =0.142 nM) antagonist.
  • HY-111385
    UNC9994 hydrochloride
    		Agonist 98.83%
    UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling.
  • HY-B1371A
    Spiperone hydrochloride
    		Antagonist 99.10%
    Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist.
  • HY-B0410A
    Pramipexole dihydrochloride hydrate
    		Agonist ≥98.0%
    Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively.
  • HY-17410
    Iloperidone
    		Antagonist 99.97%
    Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist.
  • HY-103104
    Fananserin
    		Antagonist 99.97%
    Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor.
  • HY-100820
    Sarizotan
    		Agonist 98.74%
    Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist.
  • HY-14782
    Adoprazine
    		Antagonist 98.10%
    Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors.