1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. L-741626

L-741626 

Cat. No.: HY-101348 Purity: >99.0%
Handling Instructions

L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively.

For research use only. We do not sell to patients.

L-741626 Chemical Structure

L-741626 Chemical Structure

CAS No. : 81226-60-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 135 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 Get quote
10 mg USD 305 Get quote
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively[1].

IC50 & Target

Ki: 2.4 nM (human D2 receptor), 100 nM (human D3 receptor), 220 nM (human D4 receptor)[1]

In Vitro

Intrinsic activities in a functional assay using inhibition of quinpirole stimulation of mitogenesis in human dopamine D2 or D3 receptors transfected into Chinese hamster ovary (CHO) cells, L-741626 is prepared by literature methods (Ki (D2)=11.2 nM) and displays a D3/D2 and D4/D2 selectivity ratio of 15-fold and 136-fold, respectively. In the functional assay L-741626 is a potent antagonist (EC50 (D2)=4.46 nM) with some D2 selectivity (EC50 (D3)=90.4 nM)[2].

In Vivo

L-741626 (1.0 mg/kg; i.h.) is effective at shifting to the right the pramipexole dose-response curve in pramipexole-trained male Sprague Dawley rats[3].
Coadministrating Cocaine with the D2 antagonist L-741626 (3 mg/kg; i.p.; 15 min before Cocaine) for 5 days reduces the Cocaine-induced increase in microglial TNF-α production in adult mice[4].

Molecular Weight

340.85

Formula

C₂₀H₂₁ClN₂O

CAS No.

81226-60-0

SMILES

OC1(C2=CC=C(Cl)C=C2)CCN(CC3=CNC4=C3C=CC=C4)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

L-741626L741626L 741626Dopamine ReceptordopaminereceptorTNF-αproductionselectiveInhibitorinhibitorinhibit

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L-741626
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HY-101348
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