1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Pramipexole dihydrochloride

Pramipexole dihydrochloride 

Cat. No.: HY-17355 Purity: ≥98.0%
Handling Instructions

Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

For research use only. We do not sell to patients.

Pramipexole dihydrochloride Chemical Structure

Pramipexole dihydrochloride Chemical Structure

CAS No. : 104632-25-9

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Based on 1 publication(s) in Google Scholar

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Description

Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

In Vitro

Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM[1].
Pramipexole dihydrochloride (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3].
Pramipexole dihydrochloride attenuates levodopa-induced toxicity in mesencephalic cultures, suggests that pramipexole may be cytoprotective to dopamine neurons in tissue culture[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pramipexole dihydrochloride (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals[5].
Pramipexole dihydrochloride improves neurological recovery[5].
Pramipexole dihydrochloride prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 250-300 g (16-18 weeks old)[5]
Dosage: 0.25 mg/kg, 1 mg/kg
Administration: Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusion
Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
Clinical Trial
Molecular Weight

284.25

Formula

C₁₀H₁₉Cl₂N₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (175.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5180 mL 17.5902 mL 35.1803 mL
5 mM 0.7036 mL 3.5180 mL 7.0361 mL
10 mM 0.3518 mL 1.7590 mL 3.5180 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Pramipexole dihydrochloride
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