1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Pramipexole dihydrochloride hydrate

Pramipexole dihydrochloride hydrate 

Cat. No.: HY-B0410A Purity: >98.0%
Handling Instructions

Pramipexole dihydrochloride hydrate is a selective dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole dihydrochloride hydrate can cross the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

Pramipexole dihydrochloride hydrate Chemical Structure

Pramipexole dihydrochloride hydrate Chemical Structure

CAS No. : 191217-81-9

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Pramipexole dihydrochloride hydrate is a selective dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole dihydrochloride hydrate can cross the blood-brain barrier (BBB)[1][2][3].

IC50 & Target[1]

D2 Receptor

3.9 nM (Ki)

D3 Receptor

0.5 nM (Ki)

D4 Receptor

1.3 nM (Ki)

D2-type receptors

2.2 nM (Ki)

In Vitro

Pramipexole dihydrochloride hydrate (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3].
Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures, suggests that pramipexole may be cytoprotective to dopamine neurons in tissue culture[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals[5].
Pramipexole dihydrochloride hydrate improves neurological recovery[5].
Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 250-300 g (16-18 weeks old)[5]
Dosage: 0.25 mg/kg, 1 mg/kg
Administration: Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusion
Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
Clinical Trial
Molecular Weight

302.26

Formula

C₁₀H₂₁Cl₂N₃OS

CAS No.

191217-81-9

SMILES

[H]Cl.NC1=NC(CC[[email protected]](NCCC)C2)=C2S1.[H]Cl.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
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Keywords:

Pramipexole dihydrochlorideDopamine ReceptorParkinson'sdiseasePDrestlesslegssyndromeRLSneurologicalrecoveryneuroprotectiontMCAOtransientmiddlecerebralarteryocclusionInhibitorinhibitorinhibit

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