1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Pramipexole dihydrochloride hydrate

Pramipexole dihydrochloride hydrate 

Cat. No.: HY-B0410A Purity: ≥98.0%
Handling Instructions

Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

For research use only. We do not sell to patients.

Pramipexole dihydrochloride hydrate Chemical Structure

Pramipexole dihydrochloride hydrate Chemical Structure

CAS No. : 191217-81-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pramipexole dihydrochloride hydrate:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pramipexole dihydrochloride hydrate

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  • Purity & Documentation

  • References

  • Customer Review

Description

Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

IC50 & Target[1]

D2 Receptor

3.9 nM (Ki)

D3 Receptor

0.5 nM (Ki)

D4 Receptor

1.3 nM (Ki)

D2-type receptors

2.2 nM (Ki)

In Vitro

Pramipexole dihydrochloride hydrate shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM[1].
Pramipexole dihydrochloride hydrate (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3].
Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals[5].
Pramipexole dihydrochloride hydrate improves neurological recovery[5].
Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 250-300 g (16-18 weeks old)[5]
Dosage: 0.25 mg/kg, 1 mg/kg
Administration: Intraperitoneal injection
Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
Clinical Trial
Molecular Weight

302.26

Formula

C10H21Cl2N3OS

CAS No.
SMILES

[H]Cl.NC1=NC(CC[[email protected]](NCCC)C2)=C2S1.[H]Cl.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (330.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3084 mL 16.5420 mL 33.0841 mL
5 mM 0.6617 mL 3.3084 mL 6.6168 mL
10 mM 0.3308 mL 1.6542 mL 3.3084 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (6.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (6.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (6.62 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Pramipexole dihydrochloride hydrate
Cat. No.:
HY-B0410A
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