Search Result

Results for "

middle

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Apoptosis (2) Bacterial (7) Bcl-2 Family (2) Caspase (1) Dopamine Receptor (2) Drug Metabolite (1) Endogenous Metabolite (7) ERK (1) HSP (1) Interleukin Related (1) Isotope-Labeled Compounds (4) nAChR (2) NKCC (2) Phosphodiesterase (PDE) (2) PI3K (1) PKD (1) Reactive Oxygen Species (1) SARS-CoV (1) Toll-like Receptor (TLR) (1) Trk Receptor (1) TRP Channel (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (4) Infection (5) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (13)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126049

(S)-Oxiracetam (S)-(-)-Oxiracetam; (S)-ISF2522	Apoptosis	Neurological Disease
(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke .

HY-13056

SMND-309	Drug Metabolite	Neurological Disease
SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats .

HY-Y0366

Lauric acid

Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively .

Lauric acid
Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively .

HY-Y0366S3

Lauric acid-d3	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Infection
Lauric acid-d₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S

Lauric acid-13C	Endogenous Metabolite Bacterial	Infection
Lauric acid- ¹³C is the ¹³C labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S1

Lauric acid-d23	Endogenous Metabolite Bacterial	Infection
Lauric acid-d₂₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S2

Lauric acid-d2	Isotope-Labeled Compounds Endogenous Metabolite Bacterial
Lauric acid-d₂ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S5

Lauric acid-d5	Isotope-Labeled Compounds Endogenous Metabolite Bacterial
Lauric acid-d₅ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366R

Lauric acid (Standard)	Endogenous Metabolite Bacterial	Infection
Lauric acid (Standard) is the analytical standard of Lauric acid. This product is intended for research and analytical applications. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S4

Lauric acid-13C-1	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Cardiovascular Disease
Lauric acid- ¹³C-1 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively[1].

HY-124304

Pinokalant LOE-908	TRP Channel SARS-CoV	Neurological Disease
Pinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity .

HY-N8931

Monomethyl lithospermate Lithospermic acid monomethyl ester	Akt	Neurological Disease
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) .

HY-121833

Gambogic amide	Trk Receptor Akt ERK	Neurological Disease Cancer
Gambogic amide is a potent and selective agonist of TrkA and also induces its tyrosine phosphorylation and activation of downstream signaling, including Akt and MAPK. Gambogic amide specifically interacts with the cytoplasmic juxtamembrane domain of the TrkA receptor and triggers its dimerization, leading to activation. Gambogic amide has neuroprotective activity preventing glutamate-induced neuronal cell death. Gambogic amide has improved efficacy in a transient middle cerebral artery occlusion model of stroke and could be used to study neurodegenerative diseases and stroke .

HY-10679

PF-03049423 free base	Phosphodiesterase (PDE)	Neurological Disease
PF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC₅₀ of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke .

HY-10679A

PF-03049423	Phosphodiesterase (PDE)	Neurological Disease
PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC₅₀ of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke .

HY-149164

BTB09089	Others	Neurological Disease Inflammation/Immunology
BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages .

HY-100206

5α-Androstane-3β,5,6β-triol
5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo .

HY-N0361

Dihydrocapsaicin 1 Publications Verification	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K	Cardiovascular Disease Neurological Disease
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-17468A

Bumetanide sodium Ro 10-6338 sodium; PF 1593 sodium	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide sodium, a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor, and also inhibits NKCC2, with IC₅₀s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-17468

Bumetanide 3 Publications Verification Ro 10-6338; PF 1593	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-107202

Polyinosinic-polycytidylic acid Maximum Cited Publications 13 Publications Verification Poly(I:C)	Toll-like Receptor (TLR) PKD HSP Bcl-2 Family Interleukin Related	Infection Inflammation/Immunology Cancer
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .

HY-17355

Pramipexole dihydrochloride 4 Publications Verification	Dopamine Receptor	Neurological Disease
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) .

HY-B0410

Pramipexole 4 Publications Verification	Dopamine Receptor	Neurological Disease
Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) .

HY-107666

PHA 568487	nAChR	Neurological Disease Inflammation/Immunology
PHA 568487 a selective agonist of alpha-7 nicotinic acetylcholine receptor (α-7 nAchR) .PHA 568487 reduces neuroinflammation and oxidative stress . PHA-568487 has rapid brain penetration .

HY-129674

PHA 568487 free base	nAChR	Neurological Disease
PHA 568487 free base is a selective alpha 7 nicotinic acetylcholine receptor (α-7 nAchR) agonist. PHA 568487 free base reduces neuroinflammation .

EE epitope	Peptides	Others
EE epitope is a biological active peptide. (This peptide is a 314 to 319 amino acids fragment of the middle T antigen of mouse polymavirus. Glu-Glu epitope peptide is widely used as an epitope tag.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0361

Dihydrocapsaicin 1 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Metabolic Disease Plants Solanaceae Disease Research Fields	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-Y0366R

Lauric acid (Standard)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial
Lauric acid (Standard) is the analytical standard of Lauric acid. This product is intended for research and analytical applications. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-N8931

Monomethyl lithospermate Lithospermic acid monomethyl ester	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Akt
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) .

Cat. No.	Product Name	Chemical Structure

HY-Y0366S3

Lauric acid-d3
Lauric acid-d₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S1

Lauric acid-d23
Lauric acid-d₂₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S

Lauric acid-13C
Lauric acid- ¹³C is the ¹³C labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S2

Lauric acid-d2
Lauric acid-d₂ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S5

Lauric acid-d5
Lauric acid-d₅ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S4

Lauric acid-13C-1
Lauric acid- ¹³C-1 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively[1].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

middle

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products