1. Membrane Transporter/Ion Channel
  2. NKCC
  3. Bumetanide

Bumetanide (Synonyms: Ro 10-6338; PF 1593)

Cat. No.: HY-17468 Purity: 99.91%
Handling Instructions

Bumetanide (Ro 10-6338;PF 1593) is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

For research use only. We do not sell to patients.

Bumetanide Chemical Structure

Bumetanide Chemical Structure

CAS No. : 28395-03-1

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10 mM * 1 mL in DMSO USD 117 In-stock
Estimated Time of Arrival: December 31
1 g USD 106 In-stock
Estimated Time of Arrival: December 31
5 g USD 432 In-stock
Estimated Time of Arrival: December 31
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Description

Bumetanide (Ro 10-6338;PF 1593) is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[4].

Clinical Trial
Molecular Weight

364.42

Formula

C₁₇H₂₀N₂O₅S

CAS No.

28395-03-1

SMILES

O=C(O)C1=CC(NCCCC)=C(OC2=CC=CC=C2)C(S(=O)(N)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (274.41 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7441 mL 13.7204 mL 27.4409 mL
5 mM 0.5488 mL 2.7441 mL 5.4882 mL
10 mM 0.2744 mL 1.3720 mL 2.7441 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.91%

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Bumetanide
Cat. No.:
HY-17468
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