1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. (+)-Bicuculline

(+)-Bicuculline (Synonyms: d-Bicuculline)

Cat. No.: HY-N0219 Purity: 99.97%
Handling Instructions

(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.

For research use only. We do not sell to patients.

(+)-Bicuculline Chemical Structure

(+)-Bicuculline Chemical Structure

CAS No. : 485-49-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
50 mg USD 72 In-stock
Estimated Time of Arrival: December 31
100 mg USD 108 In-stock
Estimated Time of Arrival: December 31
250 mg USD 228 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.

Molecular Weight

367.35

Formula

C₂₀H₁₇NO₆

CAS No.

485-49-4

SMILES

O=C1O[[email protected]@H]([[email protected]]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=CC=C(OCO6)C6=C51

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (98.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7222 mL 13.6110 mL 27.2220 mL
5 mM 0.5444 mL 2.7222 mL 5.4444 mL
10 mM 0.2722 mL 1.3611 mL 2.7222 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.97%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
(+)-Bicuculline
Cat. No.:
HY-N0219
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