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Bicuculline

(Synonyms: (+)-Bicuculline)
40 Cited Publications
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Based on 40 publication(s) in Google Scholar

Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice.

For research use only. We do not sell to patients.

  • Purity: 99.98%
  • CAS No.: 485-49-4
  • Formula: C20H17NO6
  • Molecular Weight:367.35
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Bicuculline Chemical Structure
    Bicuculline Chemical Structure
  • Experimental Validation Results for Bicuculline
  • Experimental Validation Results for Bicuculline
  • Experimental Validation Results for Bicuculline
  • Experimental Validation Results for Bicuculline
  • Experimental Validation Results for Bicuculline
CAS No.: 485-49-4
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Bicuculline Chemical Structure
    Bicuculline Chemical Structure
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    Bicuculline purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 20:e07908. [Abstract]

    Customer Validation
     GABAA receptor antagonist (Bicuculline, 5 µg/10 µL, i.t.) weakened acute morphine analgesic effect.

  • 1/16

    Bicuculline purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 16:e2407387. [Abstract]

    Customer Validation
     Bicuculline (100 ng; 0.5 μL; infusion pump). Paw withdrawal responses to the 0.07 g von Frey filament following mPFC injection of physiological saline or Bicuculline (Bic) within 2 hours after intraperitoneal PTX injection.

  • 1/16

    Bicuculline purchased from MedChemExpress. Usage Cited in: Cell. 2023 Mar 30;186(7):1352-1368.e18. [Abstract]

    Customer Validation
     The antidepressant-like effect of activation of MGA1 in the FST was attenuated by A1 infusion of Bicuculline (BIC, 20 μM; infusion pump).

  • 1/16

    Bicuculline purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Mar 28;12(7):3057-3078. [Abstract]

    Customer Validation
     Bicuculline (3.5 mg/kg; subcutaneous injections). Western blot analyses of Gabra1, Gabra3, Gabra5, Gabrb3, Gabrg2, KCC2 and GAPDH in the lesion sites from different groups at 4 wpt.

  • 1/16

    Bicuculline purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Mar 28;12(7):3057-3078. [Abstract]

    Customer Validation
     Bicuculline (3.5 mg/kg; subcutaneous injections). Representative IF images of transverse spinal cord sections from the Intact, +PBS, +PBS+Bic, +MSC, and +MSC+Bic groups at 4 wpt.

  • Bicuculline