2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. (-)-Bicuculline methobromide

(-)-Bicuculline methobromide  (Synonyms: l-Bicuculline methobromide)

Cat. No.: HY-100783 Purity: ≥99.0%
COA Handling Instructions

(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons.

For research use only. We do not sell to patients.

(-)-Bicuculline methobromide Chemical Structure

(-)-Bicuculline methobromide Chemical Structure

CAS No. : 73604-30-5

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5 mg USD 125 In-stock
10 mg USD 195 In-stock
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Based on 1 publication(s) in Google Scholar

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(-)-Bicuculline methobromide Related Antibodies

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Description

(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1].

IC50 & Target

GABAA[1]
In Vivo

(-)-Bicuculline methobromide (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat L5-SNL model[2]
Dosage: 0.6 nmol/rat
Administration: Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result: Attenuated the antiallodynic effect of Neurotropin.
Molecular Weight

462.29

Appearance

Solid

Formula

C21H20BrNO6
CAS No.
SMILES

C[N+]1(C)[C@@H]([C@H]2OC(C3=C4OCOC4=CC=C32)=O)C5=C(C=C6C(OCO6)=C5)CC1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1631 mL 10.8157 mL 21.6314 mL
5 mM 0.4326 mL 2.1631 mL 4.3263 mL
10 mM 0.2163 mL 1.0816 mL 2.1631 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (260 KB)

Handling Instructions (2659 KB)
References
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(-)-Bicuculline methobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(-)-Bicuculline methobromide73604-30-5l-Bicuculline methobromideGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorBicucullinemethobromideGABA(A)afterhyperpolarizationsAHPsneuronsInhibitorinhibitorinhibit

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