1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. (-)-Bicuculline methobromide

(-)-Bicuculline methobromide (Synonyms: l-Bicuculline methobromide)

Cat. No.: HY-100783
Handling Instructions

(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons.

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(-)-Bicuculline methobromide Chemical Structure

(-)-Bicuculline methobromide Chemical Structure

CAS No. : 73604-30-5

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Description

(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1].

IC50 & Target

GABAA[1]

In Vivo

(-)-Bicuculline methobromide (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2].

Animal Model: Rat L5-SNL model[2]
Dosage: 0.6 nmol/rat
Administration: Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result: Attenuated the antiallodynic effect of Neurotropin.
Molecular Weight

462.29

Formula

C₂₁H₂₀BrNO₆

CAS No.

73604-30-5

SMILES

C[N+]1(C)[[email protected]@H]([[email protected]]2OC(C3=C4OCOC4=CC=C32)=O)C5=C(C=C6C(OCO6)=C5)CC1.[Br-]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(-)-Bicuculline methobromidel-Bicuculline methobromideGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorBicucullinemethobromideGABA(A)afterhyperpolarizationsAHPsneuronsInhibitorinhibitorinhibit

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(-)-Bicuculline methobromide
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HY-100783
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