1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. GABA Receptor
    Endogenous Metabolite
  3. Propofol

Propofol (Synonyms: 2,6-Diisopropylphenol)

Cat. No.: HY-B0649 Purity: 99.52%
Handling Instructions

Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic.

For research use only. We do not sell to patients.

Propofol Chemical Structure

Propofol Chemical Structure

CAS No. : 2078-54-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Propofol (i.p.; 40 mg/kg) causes full recovery from sedation occurred 36.3 mins. There is residual antinociception when assessed by ECT but not when assessed by noxious heat[1].

Molecular Weight

178.27

Formula

C₁₂H₁₈O

CAS No.

2078-54-8

SMILES

OC1=C(C(C)C)C=CC=C1C(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (560.95 mM; Need ultrasonic)

H2O : 1 mg/mL (5.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6095 mL 28.0473 mL 56.0947 mL
5 mM 1.1219 mL 5.6095 mL 11.2189 mL
10 mM 0.5609 mL 2.8047 mL 5.6095 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (14.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (14.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (14.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Propofol2,6-DiisopropylphenolGABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorglutamatereceptorexcitatorysynaptictransmissionantinociceptivesedationhypnoticInhibitorinhibitorinhibit

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Propofol
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HY-B0649
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