Dimethyl sulfoxide, meets analytical specification of Ch.P.
(Synonyms: DMSO, meets analytical specification of Ch.P.)
387 Cited Publications
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Based on 387 publication(s) in Google Scholar
Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties.
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.
For research use only. We do not sell to patients.
- Purity : 99.98%
- CAS No.: 67-68-5
- Formula: C2H6OS
- Molecular Weight:78.13
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Dimethyl sulfoxide (Standard)
Publications Citing Use of MedChemExpress (MCE) Dimethyl sulfoxide, meets analytical specification of Ch.P.
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- J Cardiothorac Surg. 2023 Mar 24;18(1):92. [Abstract]
- Biosci Biotechnol Biochem. 2023 Nov 21;87(12):1485-1494. [Abstract]
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Biological Activity
Description
Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties[1][2][3].
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Erythroleukemia cell line | IC50 |
280 mM
Compound: DMSO
|
Anticancer activity against mouse Erythroleukemia cell line assessed as inhibition of cell growth
Anticancer activity against mouse Erythroleukemia cell line assessed as inhibition of cell growth
|
[PMID: 34591474] |
| HEK293 | IC50 |
232 μM
Compound: DMSO
|
Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
|
[PMID: 27108400] |
| HL-60 | IC50 |
108 μM
Compound: DMSO
|
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
|
[PMID: 27108400] |
| LN-18 | IC50 |
223 μM
Compound: DMSO
|
Antiproliferative activity against human LN18 cells after 48 hrs by MTT assay
Antiproliferative activity against human LN18 cells after 48 hrs by MTT assay
|
[PMID: 27108400] |
| MDCK-II | GI50 |
123 μM
Compound: DMSO
|
Growth inhibition of MDCK2 cells after 72 hrs by MTT assay
Growth inhibition of MDCK2 cells after 72 hrs by MTT assay
|
[PMID: 32787102] |
| MDCK-II | GI50 |
137 μM
Compound: DMSO
|
Growth inhibition of MDCK2 cells over expressing human ABCG2 after 72 hrs by MTT assay
Growth inhibition of MDCK2 cells over expressing human ABCG2 after 72 hrs by MTT assay
|
[PMID: 32787102] |
| THP-1 | IC50 |
119 μM
Compound: DMSO
|
Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay
Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay
|
[PMID: 27108400] |
In Vitro
Dimethyl sulfoxide (DMSO) is a colorless liquid. Dimethyl sulfoxide is a polar, aprotic solvent miscible with water and able to dissolve an enormous catalog of polar and nonpolar small molecules.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 67-68-5
-
Appearance < 18.4 °C Solid, > 18.4 °C Liquid
-
Molecular Weight 78.13
-
Formula C2H6OS
-
Color Colorless to off-white
-
SMILES
O=S(C)C
-
Synonyms
DMSO, meets analytical specification of Ch.P.
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (387)
All
Journal Impact Factor
-
Journal Impact Factor
-
Most Recent
-
Signal Transduct Target Ther
The noncanonical function of liver-type phosphofructokinase potentiates the efficacy of HDAC inhibitors in cancer. [Abstract]2025 Oct 14;10(1):341. PMID: 41083431 -
Signal Transduct Target Ther
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors. [Abstract]2023 Sep 25;8(1):366. PMID: 37743418 -
Cancer Cell
2025 Nov 10;43(11):2089-2105.e10. PMID: 40829591 -
Nature
2024 Aug;632(8025):686-694. PMID: 39112701 -
Mol Cancer
Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway. [Abstract]2025 Mar 26;24(1):97. PMID: 40140842 -
Exploration
A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid Tumors. [Abstract]2025 Dec 18;5(6):20240396. PMID: 41476656 -
Cancer Commun (Lond)
Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA-DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m6A-dependent manner. [Abstract]2025 Nov;45(11):1583-1610. PMID: 41103024 -
Cancer Commun (Lond)
Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti-PD-1 therapy in hepatocellular carcinoma. [Abstract]2024 Nov;44(11):1231-1260. PMID: 39223929 -
Nat Immunol
2024 Aug;25(8):1422-1431. PMID: 38961274 -
-
Ann Rheum Dis
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7. [Abstract]2022 May;81(5):676-686. PMID: 35058228 -
Blood
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib. [Abstract]2016 Jun 23;127(25):3237-52. PMID: 27143257 -
Cell Stem Cell
Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity. [Abstract]2026 Mar 5;33(3):470-486.e14. PMID: 41742419 -
Cell Stem Cell
Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury. [Abstract]2024 Oct 3;31(10):1484-1500.e9. PMID: 39181130 -
Cancer Res
Targeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction. [Abstract]2026 Jul 15;86(14):3588-3603. PMID: 42084229 -
Cancer Res
Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation. [Abstract]2025 Aug 27. PMID: 40865048 -
Nat Neurosci
Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy. [Abstract]2025 Nov 24. PMID: 41286450 -
Bone Res
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis. [Abstract]2025 Jun 11;13(1):60. PMID: 40500265 -
Biomed Chromatogr
2025 Jul;39(7):e70107. PMID: 40384292 -
Autophagy
Pestivirus bovine viral diarrhea virus infection triggers lipophagy through the AMPK-PNPLA2/ATGL signaling pathway to promote viral replication. [Abstract]2025 Dec;21(12):2883-2902. PMID: 40790888 -
Autophagy
The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy. [Abstract]2025 Aug;21(8):1644-1661. PMID: 40091174 -
Autophagy
The Valsa mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple. [Abstract]2023 Jun;19(6):1745-1763. PMID: 36449354 -
Nat Protoc
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells. [Abstract]2022 May;17(5):1266-1305. PMID: 35322210 -
Nat Commun
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway. [Abstract]2025 Jan 3;16(1):289. PMID: 39753529 -
Nat Commun
CRL3Keap1 E3 ligase facilitates ubiquitin-mediated degradation of oncogenic SRX to suppress colorectal cancer progression. [Abstract]2024 Dec 3;15(1):10536. PMID: 39627198 -
Nat Commun
Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. [Abstract]2023 Dec 1;14(1):7940. PMID: 38040762 -
ACS Nano
Metallothionein 2A-Silencing Antimonene-Based Nanoagonist for Amplifying the Photothermal Immunotherapy of Gynecologic Malignancy. [Abstract]2025 Sep 16;19(36):32306-32321. PMID: 40913787 -
ACS Nano
Ultrasmall Bi@Au Schottky Heterojunction with a High Potential Barrier for Amplifying Radioimmunotherapy. [Abstract]2025 Mar 20. PMID: 40113590 -
ACS Nano
A Mitochondrial Nanoguard Modulates Redox Homeostasis and Bioenergy Metabolism in Diabetic Peripheral Neuropathy. [Abstract]2023 Nov 28;17(22):22334-22354. PMID: 37782570 -
J Adv Res
Bisphenol S drives breast cancer metastasis by inhibiting dopamine receptor D2 to activate the Akt/GSK3β oncogenic axis. [Abstract]2025 Sep 23:S2090-1232(25)00744-1. PMID: 40998253 -
J Adv Res
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway. [Abstract]2024 Nov 5:S2090-1232(24)00499-5. PMID: 39505144 -
Neuron
Piezo1-mediated mechanotransduction in choroid plexus epithelial cells governs ciliogenesis and cerebrospinal fluid homeostasis. [Abstract]2026 Mar 30:S0896-6273(26)00138-8. PMID: 41916280 -
Redox Biol
ACOD1-itaconate in macrophage attenuates oxidative stress and inflammation in benign airway stenosis by upregulating and transferring FTH1. [Abstract]2026 May:92:104133. PMID: 41865719 -
J Nanobiotechnology
CD8a antibody-functionalized biomimetic red blood cell membrane ectosomes delivering C646 reverse CD8⁺ T Cell exhaustion via H3K18la histone delactylation in gastric cardia adenocarcinoma. [Abstract]2026 Jan 29;24(1):156. PMID: 41612336 -
J Nanobiotechnology
Nanosilicates facilitate periodontal regeneration potential by activating the PI3K-AKT signaling pathway in periodontal ligament cells. [Abstract]2024 Sep 3;22(1):532. PMID: 39223550 -
Theranostics
FOS-driven inflammatory CAFs promote colorectal cancer liver metastasis via the SFRP1-FGFR2-HIF1 axis. [Abstract]2025 Mar 21;15(10):4593-4613. PMID: 40225580 -
Biomark Res
Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia. [Abstract]2023 Jan 24;11(1):8. PMID: 36691065 -
J Exp Clin Cancer Res
Bufalin inhibits hepatocellular carcinoma progression by blocking EGFR-mediated RAS-RAF-MEK-ERK pathway activation. [Abstract]2025 Aug 29;44(1):260. PMID: 40883741 -
J Exp Clin Cancer Res
OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway. [Abstract]2024 Dec 26;43(1):330. PMID: 39721999 -
Adv Sci (Weinh)
ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A-Modified Trim25 to Control the Autophagy Process. [Abstract]2026 Jun 18:e76122. PMID: 42314059 -
Adv Sci (Weinh)
Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2-NETs-Mediated Liver-Bile Barrier Damage. [Abstract]2026 Apr;13(24):e19500. PMID: 41698066 -
Adv Sci (Weinh)
Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease. [Abstract]2025 Dec 29:e15138. PMID: 41462565 -
Adv Sci (Weinh)
Globotriaosylceramide Gb3 Influences Wound Healing and Scar Formation by Orchestrating Fibroblast Heterogeneity. [Abstract]2025 Aug 14:e09733. PMID: 40810720 -
Adv Sci (Weinh)
2025 Jun;12(23):e2416489. PMID: 40390546 -
Adv Sci (Weinh)
Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2. [Abstract]2023 Oct;10(28):e2302130. PMID: 37544908 -
Cell Rep Med
5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation. [Abstract]2026 Jan 20;7(1):102537. PMID: 41494533 -
Sci Adv
Label-free, real-time monitoring of cytochrome C drug responses in microdissected tumor biopsies with a multi-well aptasensor platform. [Abstract]2024 Sep 6;10(36):eadn5875. PMID: 39241078 -
Cell Death Differ
p53 transcriptionally activates DCP1B to suppress tumor progression and enhance tumor sensitivity to PI3K blockade in non-small cell lung cancer. [Abstract]2025 Apr 9. PMID: 40200093 -
-
Cell Death Dis
2026 May 16. PMID: 42140904 -
Cell Mol Biol Lett
Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis. [Abstract]2025 Jul 28;30(1):93. PMID: 40722060 -
Cell Death Dis
Intratumoral Brevibacillus parabrevis enhances antitumor immunity by inhibiting NK cell ferroptosis in hepatocellular carcinoma. [Abstract]2025 May 21;16(1):407. PMID: 40399270 -
Environ Sci Technol
Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models. [Abstract]2025 Apr 3. PMID: 40178189 -
Int J Biol Sci
Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma. [Abstract]2026 Jan 1;22(1):161-177. PMID: 41362739 -
Int J Biol Sci
Olaparib combined with CDK12-IN-3 to promote genomic instability and cell death in ovarian cancer. [Abstract]2024 Aug 19;20(11):4513-4531. PMID: 39247812 -
J Neuroinflammation
Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss. [Abstract]2024 Nov 14;21(1):295. PMID: 39543619 -
J Neuroinflammation
The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray. [Abstract]2022 Dec 22;19(1):310. PMID: 36550542 -
Mol Ther
2025 Jan 8;33(1):279-296. PMID: 39521960 -
-
Phytomedicine
Cyasterone regulates lipid metabolism and autophagy mediated by the AMPK signaling pathway to improve KOA synovitis. [Abstract]2026 Apr:153:157937. PMID: 41687535 -
Phytomedicine
Berberine facilitates alveolar bone regeneration via Ptgs2-mediated dual regulation of osteoblast differentiation and fibroblast inhibition. [Abstract]2026 Jan:150:157678. PMID: 41401587 -
Phytomedicine
Licochalcone B targets neural cell adhesion molecule 1 to inhibit osteosarcoma progression and ferroptosis resistance via extracellular signal-regulated kinase 5 and nuclear factor kappa B pathways. [Abstract]2026 Jan:150:157584. PMID: 41349457 -
Phytomedicine
Jianpi Huayu decoction exerts antitumor effects in pancreatic cancer via SCD1-mediated lipid metabolism remodeling/ferroptosis axis. [Abstract]2025 Nov 25:148:157389. PMID: 41101075 -
Phytomedicine
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence. [Abstract]2025 Jun:141:156697. PMID: 40215820 -
Phytomedicine
Cryptotanshinone alleviates immunosuppression in endometriosis by targeting MDSCs through JAK2/STAT3 pathway. [Abstract]2025 Jan:136:156227. PMID: 39580997 -
Phytomedicine
Timosaponin AIII induces lipid peroxidation and ferroptosis by enhancing Rab7-mediated lipophagy in colorectal cancer cells. [Abstract]2024 Jan:122:155079. PMID: 37863004 -
Phytomedicine
Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice. [Abstract]2023 May:113:154725. PMID: 36867963 -
EBioMedicine
Effects of gestational perfluorohexanesulfonic acid exposure at human realistic dose on social communication deficit in mouse offspring. [Abstract]2026 Mar:125:106160. PMID: 41671867 -
Mater Today Bio
Nanoparticles coated with osteoblast-like cell membranes as curcumin delivery vehicles for targeted postmenopausal osteoporosis therapy. [Abstract]2025 Dec 9:36:102636. PMID: 41497898 -
Mater Today Bio
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy. [Abstract]2025 Oct 1:35:102359. PMID: 41104046 -
Adv Healthc Mater
Engineered Hollow Nanocomplex Combining Photothermal and Antioxidant Strategies for Targeted Tregs Depletion and Potent Immune Activation in Tumor Immunotherapy. [Abstract]2025 Jun;14(15):e2405124. PMID: 40109122 -
Clin Cancer Res
UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma. [Abstract]2025 Jul 8. PMID: 40627452 -
Environ Health Perspect
Evaluating the Effect of Gestational Exposure to Perfluorohexane Sulfonate on Placental Development in Mice Combining Alternative Splicing and Gene Expression Analyses. [Abstract]2023 Nov;131(11):117011. PMID: 37995155 -
Acta Pharmacol Sin
GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating. [Abstract]2025 Sep 10. PMID: 40931040 -
Mol Psychiatry
Anterior insular cortex regulates depression-like and ASD-like behaviors via the differential contribution of two subsets of microglia. [Abstract]2025 Aug 6. PMID: 40770435 -
Cell Death Discov
TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer. [Abstract]2025 Feb 5;11(1):47. PMID: 39910045 -
Cell Death Discov
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing. [Abstract]2024 May 29;10(1):263. PMID: 38811564 -
Environ Int
Integrated network toxicology and transcriptomics reveal NF-κB signaling as a key mediator of TDCPP-induced inflammatory responses in human microglia. [Abstract]2026 Jun 15:214:110373. PMID: 42314475 -
Environ Int
Di-n-butyl phthalate induces NF-κB-mediated senescence-associated secretory phenotype to promote epithelial proliferation, epithelial-mesenchymal transition, and benign prostatic hyperplasia. [Abstract]2026 Feb:208:110085. PMID: 41621134 -
J Orthop Translat
Phillygenin inhibits neuroinflammation and promotes functional recovery after spinal cord injury via TLR4 inhibition of the NF-κB signaling pathway. [Abstract]2024 Aug 8:48:133-145. PMID: 39220679 -
J Orthop Translat
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects. [Abstract]2023 Jan 25:39:74-87. PMID: 36788965 -
J Transl Med
CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability. [Abstract]2025 Aug 19;23(1):939. PMID: 40830962 -
J Transl Med
PXD101 inhibits malignant progression and radioresistance of glioblastoma by upregulating GADD45A. [Abstract]2024 Nov 20;22(1):1047. PMID: 39568000 -
Proc Natl Acad Sci U S A
Identification of FBLL1 as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation. [Abstract]2024 Nov 26;121(48):e2406961121. PMID: 39570315 -
Dev Cell
2025 Feb 19:S1534-5807(25)00063-2. PMID: 40020679 -
Dev Cell
Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma. [Abstract]2025 Mar 20:S1534-5807(25)00121-2. PMID: 40132584 -
Chin Med J (Engl)
Itaconate derivative 4-OI inhibits M1 macrophage polarization and restores its impaired function in immune thrombocytopenia through metabolic reprogramming. [Abstract]2025 May 29. PMID: 40437667 -
Int J Biol Macromol
Exosomal microRNA-20b-5p contributes to cytarabine resistance in acute myeloid leukemia via the microtubule-associated serine/threonine kinase-like-phosphatidylinositol 3-kinase-protein kinase B signaling axis. [Abstract]2025 Dec;333(Pt 2):148750. PMID: 41197693 -
Int J Biol Macromol
Cancer cell membrane-biomimetic and antioxidant-powered nanoplatform for overcoming multidrug resistance in triple-negative breast cancer. [Abstract]2025 Dec 6;337(Pt 1):149478. PMID: 41360238 -
Int J Biol Macromol
FKBP5 inhibitor suppresses platelet activation and thrombosis by inhibiting IKBKE/PI3K/Rap1 pathway. [Abstract]2025 Jun;311(Pt 3):144068. PMID: 40345291 -
BMC Med
Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer. [Abstract]2023 Feb 21;21(1):68. PMID: 36810084 -
Int J Mol Med
Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress. [Abstract]2026 Aug;58(2):214. PMID: 42272255 -
Int J Mol Med
STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma. [Abstract]2026 Feb;57(2):38. PMID: 41347828 -
Int J Mol Med
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway. [Abstract]2024 May;53(5):49. PMID: 38577949 -
Mol Med
Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases. [Abstract]2024 Dec 19;30(1):245. PMID: 39701924 -
Mol Med
Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice. [Abstract]2024 Nov 27;30(1):235. PMID: 39604837 -
Mol Med
BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity. [Abstract]2023 Mar 1;29(1):30. PMID: 36858954 -
Mol Med
Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL. [Abstract]2022 Nov 26;28(1):141. PMID: 36435772 -
Environ Res
Prenatal PFHxS exposure alters ovarian development in female adolescent mice: Transcriptomic, hormonal, and structural evidence of disrupted steroidogenesis. [Abstract]2026 Mar 1:294:123804. PMID: 41554311 -
Antioxidants (Basel)
Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice. [Abstract]2023 Mar 15;12(3):722. PMID: 36978970 -
Free Radic Biol Med
Echinacoside improves antioxidant responses and angiogenesis through Parkin-MFN2-mediated mitophagy to promote diabetic wound healing. [Abstract]2026 Jul:250:436-452. PMID: 41962601 -
Free Radic Biol Med
Troxerutin mitigates ferroptosis-related neuroinflammation by regulating the microglial NOX4/Nrf2 axis in Parkinson's disease. [Abstract]2026 Jun 6:254:46-61. PMID: 42252064 -
Free Radic Biol Med
Linarin alleviates high-fat diet-induced hepatic steatosis by inhibiting PDE4D and activating the cAMP/PKA/CREB pathway. [Abstract]2025 Nov:239:116-129. PMID: 40712988 -
Free Radic Biol Med
Gut microbial metabolite alleviates osteoporosis by attenuating AKT-NFATc1 signaling pathway and ROS production. [Abstract]2025 Nov 23:243:351-366. PMID: 41290102 -
Free Radic Biol Med
siHIF-1α-loaded micellar nanoparticles inhibit M1 macrophage activation to ameliorate chronic rhinosinusitis. [Abstract]2025 Sep:237:403-418. PMID: 40456494 -
Free Radic Biol Med
2025 Aug 13:240:183-196. PMID: 40816648 -
Free Radic Biol Med
2024 Feb 20:212:34-48. PMID: 38104741 -
ACS Appl Mater Interfaces
DB-PTZ: A Novel NIR-II AIE Photosensitizer for Image-Guided Photothermal and Photodynamic Therapy of Hepatocellular Carcinoma. [Abstract]2026 Apr 15;18(14):20175-20188. PMID: 41941216 -
Cell Rep
4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1. [Abstract]2026 Mar 30;45(4):117179. PMID: 41915469 -
Cell Rep
Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer. [Abstract]2025 Nov 25;44(11):116530. PMID: 41196681 -
Curr Biol
2025 Apr 7;35(7):1612-1621.e3. PMID: 40049172 -
Cell Rep
Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism. [Abstract]2025 Mar 12;44(3):115400. PMID: 40080500 -
Cell Rep
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING. [Abstract]2023 Feb 28;42(3):112145. PMID: 36862550 -
Cell Prolif
Tetrahedral framework nucleic acid-based small-molecule inhibitor delivery for ecological prevention of biofilm. [Abstract]2024 Sep;57(9):e13678. PMID: 38812355 -
Transl Psychiatry
Chronic alcohol exposure contributes to postoperative cognitive dysfunction via NR2B upregulation in the hippocampus of adult mice. [Abstract]2026 May 14. PMID: 42129152 -
Brain Behav Immun
Microglia-mediated Perineuronal nets loss contributes to social memory deficit in male mice after repeated neonatal sevoflurane exposure. [Abstract]2026 Jan:131:106148. PMID: 41138885 -
Br J Pharmacol
CircPTK2 enhances non-small cell lung cancer proliferation by inhibiting cellular senescence through stabilizing NFYA and elevating FOXM1. [Abstract]2025 Nov 7. PMID: 41204684 -
Br J Pharmacol
A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death. [Abstract]2025 May 13. PMID: 40356419 -
Br J Pharmacol
SGK3 promotes estrogen receptor-positive breast cancer proliferation by activating STAT3/ZMIZ2 pathway to stabilise β-catenin. [Abstract]2025 Apr;182(8):1856-1875. PMID: 39876548 -
Cell Mol Neurobiol
Activation of the Reverse Cholesterol Transport Pathway: A Strategy to Ameliorate Lipid Metabolic Dyshomeostasis in the Microenvironment Following Spinal Cord Injury. [Abstract]2026 Jun 19. PMID: 42321551 -
Chin Med
Psoralidin inhibits osteosarcoma growth and metastasis by downregulating ITGB1 expression via the FAK and PI3K/Akt signaling pathways. [Abstract]2023 Mar 31;18(1):34. PMID: 37004120 -
J Med Chem
Development of Novel Estradiol-Indole Hybrids Targeting SERT and ERβ as Potential Antidepressants. [Abstract]2026 Jun 11;69(11):13618-13634. PMID: 42154662 -
Int J Oncol
Targeting the cuproptosis‑associated gene COL22A1 in glioblastoma using EMD‑1204831 and kaempferol. [Abstract]2025 May;66(5):38. PMID: 40242972 -
Environ Pollut
Dibutyl phthalate exposure-induced AhR activation drives ferroptosis and HMGB1/TLR4-mediated inflammatory liver injury via NRF2-HO-1 signaling. [Abstract]2026 Jun 1:398:128010. PMID: 41887355 -
Environ Pollut
Novel insights into DBP-induced zebrafish liver inflammatory damage: Ferroptosis activating the HMGB1-TLR4-NF-κB signaling pathway. [Abstract]2025 Jul 1:376:126395. PMID: 40345373 -
Cancer Cell Int
KAT6A acetyltransferase accelerates colorectal cancer progression through upregulating BRD1 protein expression via acetylation modification. [Abstract]2025 Nov 18;25(1):413. PMID: 41254720 -
PLoS Biol
Oligomeric lactic acid nanoplastics induce intrauterine growth restriction in mice by disrupting GATA2-mediated placental vascular development. [Abstract]2026 Mar 26;24(3):e3003676. PMID: 41886399 -
Pharmaceutics
Carrier-Free Hybrid Nanoparticles for Enhanced Photodynamic Therapy in Oral Carcinoma via Reversal of Hypoxia and Oxidative Resistance. [Abstract]2024 Aug 27;16(9):1130. PMID: 39339168 -
Clin Exp Hypertens
Cinnamaldehyde alleviates pulmonary hypertension by affecting vascular remodeling through the TLR4/NF-kB/HIF-1a pathway. [Abstract]2025 Dec;47(1):2486829. PMID: 40171680 -
Antioxid Redox Signal
Endothelial Gasdermin D Induces Mitochondrial Damage and Activates the STING Pathway in Lipopolysaccharide-Accelerated Atherosclerosis. [Abstract]2025 Sep 29. PMID: 41017337 -
J Ethnopharmacol
Screening of anti-melanoma compounds from Morus alba L.: Sanggenon C promotes melanoma cell apoptosis by disrupting intracellular Ca2+ homeostasis. [Abstract]2024 Apr 24:324:117759. PMID: 38219884 -
J Ethnopharmacol
Guggulsterone from Commiphora mukul potentiates anti-glioblastoma efficacy of temozolomide in vitro and in vivo via down-regulating EGFR/PI3K/Akt signaling and NF-κB activation. [Abstract]2023 Jan 30:301:115855. PMID: 36280019 -
J Agric Food Chem
Shikonin Targets Dihydroorotase to Inhibit the Growth and Virulence of Phytopathogenic Fungi. [Abstract]2026 Jul 1;74(25):19583-19595. PMID: 42297623 -
CNS Neurosci Ther
Network Pharmacology-Based and Experimental Validation Elucidate the Target Mechanism of Vinorine in Ameliorating Secondary Brain Injury After Intracerebral Hemorrhage. [Abstract]2025 Sep;31(9):e70609. PMID: 40994248 -
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CNS Neurosci Ther
Hippocampal mitophagy contributes to spatial memory via maintaining neurogenesis during the development of mice. [Abstract]2024 Jun;30(6):e14800. PMID: 38887162 -
Biochem Pharmacol
Inhibition of mitochondrial integrated stress response ameliorates ibuprofen-induced endothelial dysfunction in neonatal hyperoxia-induced lung injury. [Abstract]2026 Jun:248:117857. PMID: 41780649 -
Biochem Pharmacol
Soluble guanylate cyclase stimulator vericiguat alleviates skeletal muscle injury and exercise capacity decline in ApoE-/- mice by inhibiting oxidative stress and repairing mitophagy. [Abstract]2026 Mar:245:117570. PMID: 41354362 -
Cell Mol Life Sci
ZNF711 promotes enzalutamide resistance through transcriptional and epigenetic modification of the androgen receptor signaling pathway. [Abstract]2026 Feb 9;83(1):103. PMID: 41656388 -
Biochem Pharmacol
Imperatorin induces ferroptosis via mediating lipid peroxidation and SLC7A11/ACSL4/GPX4 signaling for inhibition and therapeutics of prostate cancer. [Abstract]2026 Mar:245:117683. PMID: 41506540 -
Biochem Pharmacol
Deubiquitinase USP5 promotes acute myeloid leukemia through C2CD5 stabilization and PI3K/AKT/mTOR/HIF-1α-driven glycolysis. [Abstract]2026 Feb:244:117591. PMID: 41344512 -
Biochem Pharmacol
BCAA exaggerated acute and chronic ischemic heart disease through promotion of NLRP3 via Sirt1. [Abstract]2025 Nov:241:117150. PMID: 40659126 -
Cell Mol Life Sci
2025 Nov 19;82(1):408. PMID: 41258568 -
Biochem Pharmacol
Blocking the LRH-1/LCN2 axis by ML-180, an LRH-1 inverse agonist, ameliorates osteoarthritis via inhibiting the MAPK pathway. [Abstract]2025 Jul:237:116922. PMID: 40194607 -
Acta Neuropathol Commun
Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance. [Abstract]2025 Apr 25;13(1):84. PMID: 40281543 -
Biochem Pharmacol
A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway. [Abstract]2024 Aug:226:116398. PMID: 38944395 -
Biochem Pharmacol
Homoplantaginin alleviates intervertebral disc degeneration by blocking the NF-κB/MAPK pathways via binding to TAK1. [Abstract]2024 Aug:226:116389. PMID: 38914318 -
Life Sci
Compressive stress induces cartilage endplate degeneration through the Piezo1/YAP-TEAD/NLRP3 axis. [Abstract]2026 Mar 1:388:124195. PMID: 41506536 -
Life Sci
Transcranial direct current stimulation alleviates chronic pain in knee osteoarthritis by modulating microglial and astrocytic polarization and neuroinflammation. [Abstract]2025 Sep 1:376:123753. PMID: 40409582 -
Life Sci
The protective role of sulforaphane and Homer1a in retinal ischemia-reperfusion injury: Unraveling the neuroprotective interplay. [Abstract]2023 Sep 15:329:121968. PMID: 37487941 -
Life Sci
γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress. [Abstract]2023 Mar 15:317:121439. PMID: 36731645 -
Inflammopharmacology
A medicine and food homology formula prevents cognitive deficits by inhibiting neuroinflammation and oxidative stress via activating AEA-Trpv1-Nrf2 pathway. [Abstract]2024 Dec;32(6):3745-3759. PMID: 39305407 -
Inflamm Res
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury. [Abstract]2024 Nov;73(11):1981-1994. PMID: 39340662 -
Liver Int
Ferritinophagy-mediated ferroptosis facilitates methotrexate-induced hepatotoxicity by high-mobility group box 1 (HMGB1). [Abstract]2024 Mar;44(3):691-705. PMID: 38082504 -
Liver Int
2022 Dec;42(12):2889-2899. PMID: 36254713 -
Drug Des Devel Ther
2026 Mar 19:20:575342. PMID: 41878677 -
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Drug Des Devel Ther
Paroxetine as a Therapeutic Agent in Inflammatory Osteolysis: Mechanistic Insights and Efficacy. [Abstract]2026 Jan 27:20:561725. PMID: 41868178 -
J Cell Biol
2025 Oct 6;224(10):e202412224. PMID: 40728580 -
Drug Des Devel Ther
Design of a Highly Active Peptide Inhibitor of Farnesyltransferase and Its Protective Effect Against Acute Liver Failure. [Abstract]2025 Mar 13:19:1909-1926. PMID: 40098903 -
Cells
Structure-Based Virtual Screening and Mechanistic Characterization of Methotrexate and Selinexor as Potent Anti-Melanogenic Agents via Multi-Pathway Suppression of MITF. [Abstract]2026 Jun 11;15(12):1070. PMID: 42346097 -
Cells
A Comprehensive Adenoid Cystic Carcinoma-Derived Organoid Platform for Disease Modeling and Drug Screening Captures Interpatient Heterogeneity. [Abstract]2026 Feb 23;15(4):383. PMID: 41744826 -
ACS Biomater Sci Eng
2025 Oct 13;11(10):6068-6083. PMID: 40931465 -
Cells
Naringenin Targets PI3K p85alpha to Suppress PI3K/AKT Signaling Pathway and Ameliorate Disordered MMP-9 Secretion in Cigarette Smoke Extract-Induced Alveolar Macrophages In Vitro. [Abstract]2025 May 8;14(10):678. PMID: 40422181 -
J Am Heart Assoc
Microglia-Mediated Neuroimmune Response Regulates Cardiac Remodeling After Myocardial Infarction. [Abstract]2023 Jun 20;12(12):e029053. PMID: 37318008 -
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Commun Biol
P38α MAPK-induced senescence in cranial suture progenitor cells promotes craniosynostosis. [Abstract]2025 Dec 13. PMID: 41390905 -
Commun Biol
Dcaf15-mediated EphA2 degradation triggers disruption of the blood-brain barrier during Streptococcus suis meningitis. [Abstract]2025 Nov 23. PMID: 41276610 -
Commun Biol
Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis. [Abstract]2025 Jul 5;8(1):1009. PMID: 40617906 -
Commun Biol
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway. [Abstract]2025 Jul 29;8(1):1127. PMID: 40730679 -
J Inflamm (Lond)
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways. [Abstract]2024 Aug 28;21(1):32. PMID: 39198816 -
Cancer Biol Ther
Suppression of LncRNA AC008406.3 sensitizes breast cancer cells to docetaxel via triggering cuproptosis. [Abstract]2026 Dec 31;27(1):2676474. PMID: 42189063 -
Eur J Pharmacol
Isolinderalactone targets TNF-α/STAT3 inflammatory pathways to attenuate psoriasis-like dermatitis. [Abstract]2026 Mar 28:1019:178733. PMID: 41795538 -
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Cell Biol Toxicol
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development. [Abstract]2025 Sep 2;41(1):129. PMID: 40897829 -
Clin Epigenetics
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations. [Abstract]2023 Oct 17;15(1):163. PMID: 37848946 -
Int Immunopharmacol
Kaempferol inhibits oxidative stress-induced ferroptosis via the ROS/P38MAPK pathway to delay intervertebral disc degeneration: a combinatorial study of cell, animal, and transcriptomic evidence. [Abstract]2026 Jun 15:185:116994. PMID: 42296781 -
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Biomolecules
DB-2B, a Novel and Selective STAT3 Inhibitor Inhibits Colorectal Cancer Progression In Vitro and In Vivo. [Abstract]2026 May 20;16(5):752. PMID: 42194100 -
Int Immunopharmacol
BI-2536 attenuates IPF progression by inhibiting the PLK2/JNK/SP1 Signaling pathway in AT2 cells. [Abstract]2026 Jan 1;168(Pt 1):115812. PMID: 41237696 -
Int Immunopharmacol
Cucurbitacin B suppresses malignant progression of oral leukoplakia via ferroptosis-induced macrophage polarization. [Abstract]2025 Sep 13:165:115485. PMID: 40946669 -
Int Immunopharmacol
Pan-HDAC inhibitor LAQ824 inhibits the progression of pancreatic ductal adenocarcinoma and suppresses immune escape by promoting antigen presentation. [Abstract]2025 May 8:154:114528. PMID: 40158429 -
Int Immunopharmacol
Garcinol promotes wound healing in diabetic mice by regulating inflammation and NLRP3 inflammasome-mediated pyroptosis via the PI3K/Akt/NF-κB pathway. [Abstract]2025 Apr 4:151:114352. PMID: 40022821 -
Int Immunopharmacol
Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA/NF-κB signaling pathway. [Abstract]2025 Apr 24:153:114401. PMID: 40101425 -
Int Immunopharmacol
Kojic acid alleviates osteoarthritis by attenuating inflammation and restoring impaired autophagy through regulating NF-κB and PI3K/AKT/mTOR signaling pathways: An in vivo and in vitro study. [Abstract]2025 Feb 6:147:114022. PMID: 39764993 -
Int Immunopharmacol
House dust mite induced mucosal barrier dysfunction and type 2 inflammatory responses via the MAPK/AP-1/IL-24 Signaling pathway in allergic rhinitis. [Abstract]2025 Feb 20:148:113972. PMID: 39826453 -
Int Immunopharmacol
Plumbagin improves myocardial fibrosis after myocardial infarction by inhibiting the AKT/mTOR pathway to upregulate autophagy levels. [Abstract]2025 Feb 20:148:114086. PMID: 39827666 -
Int Immunopharmacol
Neutrophil PPIF exacerbates lung ischemia-reperfusion injury after lung transplantation by promoting calcium overload-induced neutrophil extracellular traps formation. [Abstract]2024 Sep 4;142(Pt A):113051. PMID: 39236457 -
Int Immunopharmacol
Targeting lipid peroxidation-associated ferroptosis suppresses lung carcinoma progression by regulating cell cycle arrest. [Abstract]2024 Sep 10:138:112518. PMID: 38917528 -
Int J Mol Sci
2024 Jun 25;25(13):6947. PMID: 39000057 -
Int Immunopharmacol
Effect of radiation fractionation on IDO1 via the NF-κB/COX2 axis in non-small cell lung cancer. [Abstract]2023 Sep 24;124(Pt B):110956. PMID: 37751656 -
Int J Mol Sci
The Properties of Linezolid, Rifampicin, and Vancomycin, as Well as the Mechanism of Action of Pentamidine, Determine Their Synergy against Gram-Negative Bacteria. [Abstract]2023 Sep 7;24(18):13812. PMID: 37762115 -
Int J Mol Sci
Histone Deacetylase Inhibitor (SAHA) Reduces Mortality in an Endotoxemia Mouse Model by Suppressing Glycolysis. [Abstract]2023 Aug 4;24(15):12448. PMID: 37569823 -
Int Immunopharmacol
Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway. [Abstract]2023 Jun:119:110204. PMID: 37126988 -
Int J Mol Sci
PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice. [Abstract]2023 Jun 9;24(12):9954. PMID: 37373102 -
Int J Mol Sci
Oxidative Stress and Endoplasmic Reticulum Stress Contributes to Arecoline and Its Secondary Metabolites-Induced Dyskinesia in Zebrafish Embryos. [Abstract]2023 Mar 28;24(7):6327. PMID: 37047326 -
Int J Mol Sci
Activation of the RARα Attenuated CSF Hypersecretion to Inhibit Hydrocephalus Development via Regulating the MAFB/MSR1 Pathway. [Abstract]2023 Jan 30;24(3):2586. PMID: 36768908 -
Int Immunopharmacol
Blockade of JAK2 retards cartilage degeneration and IL-6-induced pain amplification in osteoarthritis. [Abstract]2022 Dec;113(Pt A):109340. PMID: 36330910 -
Int Immunopharmacol
JMJD3/H3K27me3 epigenetic modification regulates Th17/Treg cell differentiation in ulcerative colitis. [Abstract]2022 Sep:110:109000. PMID: 35777266 -
Mol Neurobiol
Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways. [Abstract]2025 May 22. PMID: 40402410 -
Mol Neurobiol
Electroacupuncture Exerts Analgesic Effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory Pain. [Abstract]2024 May;61(5):2949-2963. PMID: 37957422 -
mBio
Tyrosine kinase LYN restricts the replication and virulence of influenza A virus by directly phosphorylating viral nucleoprotein. [Abstract]2026 May 13;17(5):e0375925. PMID: 41910156 -
mBio
The swine acute diarrhea syndrome coronavirus spike protein promotes syncytial formation via upregulation of cellular cholesterol synthesis. [Abstract]2025 Aug 13;16(8):e0097625. PMID: 40586601 -
J Pathol
Circulating metabolomics reveals guanosine monophosphate synthetase (GMPS) as a novel therapeutic target in lung adenocarcinoma. [Abstract]2025 Aug;266(4-5):465-480. PMID: 40539844 -
BMC Biol
CDK1 mediates the metabolic regulation of DNA double-strand break repair in metaphase II oocytes. [Abstract]2025 Feb 6;23(1):37. PMID: 39915808 -
mBio
PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication. [Abstract]2024 Feb 14;15(2):e0319723. PMID: 38259103 -
Front Pharmacol
WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis. [Abstract]2022 Sep 16;13:976117. PMID: 36188586 -
Toxicology
MEHP exposure disrupts the self-renewal and differentiation of GC-1 cells by up-regulating m6A levels, leading to reproductive damage in immature rats. [Abstract]2026 May 14:154495. PMID: 42140473 -
Chem Biol Interact
FB1 causes barrier damage to vascular endothelial cells through ferroptosis by a PINK1/Parkin mediated mitophagy-dependent mechanism. [Abstract]2025 Aug 1:416:111536. PMID: 40324642 -
Toxicology
Bisphenol S promotes clear cell renal cell carcinoma progression by modulating the WNT5A-dependent EMT pathway. [Abstract]2025 Jun:514:154117. PMID: 40086502 -
ACS Omega
Dynamic Detection of the E3-PROTAC-Target Protein Ternary Complex In Vitro and In Vivo via Bimolecular Fluorescence Complementation. [Abstract]2024 Dec 3;9(50):49739-49748. PMID: 39713624 -
Toxicology
2024 Nov:508:153923. PMID: 39147090 -
Chem Biol Interact
EGCG inhibits migration, invasion and epithelial-mesenchymal transition of renal cell carcinoma by activating TFEB-mediated autophagy. [Abstract]2024 Nov 1:403:111250. PMID: 39313106 -
ACS Omega
Highly Efficient Photoelectrochemical Detection of Cystatin C Based on a Core-Shell MOF Nanocomposite with Biomimetic-Catalysis Amplification. [Abstract]2024 Jun 14;9(26):28228-28236. PMID: 38973831 -
Molecules
Peroxiredoxin 4 Ameliorates T-2 Toxin-Induced Growth Retardation in GH3 Cells by Inhibiting Oxidative Stress and Apoptosis. [Abstract]2024 Nov 21;29(23):5491. PMID: 39683652 -
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Sci Rep
Hyperuricemia aggravates acute pancreatitis through CNR1-mediated inflammatory signaling and gut-pancreas axis dysregulation: a multi-omics and clinical study. [Abstract]2026 Jun 4. PMID: 42243316 -
Sci Rep
Targeting STAT3 pathway attenuates macrophages inflammation and cardiovascular injury in a model of Kawasaki disease. [Abstract]2026 Mar 21;16(1):14358. PMID: 41865139 -
Sci Rep
Combination of artesunate and ruxolitinib suppresses T cell leukemia/lymphoma proliferation via the JAK STAT pathway. [Abstract]2026 Feb 11;16(1):8354. PMID: 41673103 -
Sci Rep
Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI. [Abstract]2025 Jul 11;15(1):25045. PMID: 40646091 -
Sci Rep
Mitigating cardiac allograft vasculopathy in a murine model via CD40-TRAF6 blockade and cyclosporin A synergy. [Abstract]2025 Jul 1;15(1):22327. PMID: 40595221 -
Toxics
2025 Apr 23;13(5):332. PMID: 40423411 -
Sci Rep
Decreased PD-L1 contributes to preeclampsia by suppressing GM-CSF via the JAK2/STAT5 signal pathway. [Abstract]2025 Jan 24;15(1):3124. PMID: 39856320 -
Sci Rep
Clusterin mediates hydroquinone-induced cytotoxic responses in HL-60 differentiated cells. [Abstract]2024 Dec 5;14(1):30402. PMID: 39638872 -
Sci Rep
Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway. [Abstract]2024 Nov 16;14(1):28327. PMID: 39550364 -
Mediators Inflamm
Autophagy Improves Inflammatory Response in Sepsis Accompanied by Changes in Gut Microbiota. [Abstract]2024 Oct 18:2024:9550301. PMID: 39465181 -
Mediators Inflamm
Cryptotanshinone Inhibits Bladder Cancer Cell Malignant Progression in a Lipopolysaccharide-Induced Inflammatory Microenvironment through NLRP3 Inhibition. [Abstract]2024 Jan 30:2024:8828367. PMID: 39144184 -
Transplantation
Activation of the Aryl Hydrocarbon Receptor Ameliorates Acute Rejection of Rat Liver Transplantation by Regulating Treg Proliferation and PD-1 Expression. [Abstract]2022 Nov 1;106(11):2172-2181. PMID: 35706097 -
Cancers (Basel)
Molecular Characterization of PARP Inhibitor Response Reveals Co-Targeting Strategies in Advanced Prostate Cancer. [Abstract]2026 Jul 23;18(15):2381. PMID: 42588601 -
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Exp Neurol
2025 Aug:390:115303. PMID: 40345568 -
Pestic Biochem Physiol
2-Methoxyestradiol ameliorates paraquat-induced pulmonary fibrosis by inhibiting the TGF-β1/Smad2/3 signaling pathway. [Abstract]2023 Dec:197:105647. PMID: 38072522 -
Cancers (Basel)
Association between Dysfunction of the Nucleolar Stress Response and Multidrug Resistance in Pediatric Acute Lymphoblastic Leukemia. [Abstract]2022 Oct 19;14(20):5127. PMID: 36291909 -
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Mol Cell Biochem
Disulfidptosis-related gene DSTN predicts prognosis and promotes malignant progression in head and neck squamous cell carcinoma. [Abstract]2026 Jun;481(6):2655-2673. PMID: 42101793 -
Neuropharmacology
Ajugol ameliorates mitochondrial dysfunction and cognitive decline in Alzheimer's Disease via BNIP3-dependent mitophagy. [Abstract]2026 Jun 15:291:110923. PMID: 41819485 -
Microorganisms
Improvement of Insulin Resistance by Lactobacillus johnsonii-Derived Indole-3-Lactic Acid. [Abstract]2026 May 30;14(6):1231. PMID: 42354856 -
Mol Cell Biochem
Squalene attenuates doxorubicin resistance in hepatocellular carcinoma by targeting SIRT6 to inhibit ERK1 deacetylation. [Abstract]2026 Apr 28. PMID: 42048041 -
Microorganisms
The Effect of Variations in Temperature and Contact Time of Zingerone, [6]-Gingerol and Shogaol as Disinfectants on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. [Abstract]2026 Feb 26;14(3):539. PMID: 41900299 -
Virol Sin
Ubiquitin-specific protease 5 promotes EV-A71 replication by de-ubiquitinating MAVS and IRF3. [Abstract]2025 Dec;40(6):910-920. PMID: 41352537 -
Neuropharmacology
β-Caryophyllene prevents cognitive impairment in mice following acute sleep deprivation by alleviating hippocampal structural and functional alterations. [Abstract]2025 Oct 28:283:110752. PMID: 41167414 -
Virol Sin
Quercetin inhibits herpes simplex virus 1 replication in corneal epithelium and suppresses keratitis progression. [Abstract]2025 Aug;40(4):647-657. PMID: 40675379 -
J Cell Mol Med
Identification of LDHA as a Potential Therapeutic Target for Pulmonary Hypertension Through Modulation of Endothelial-To-Mesenchymal Transition. [Abstract]2025 Jul;29(13):e70692. PMID: 40629253 -
J Cell Mol Med
Danuglipron Ameliorates Pressure Overload-Induced Cardiac Remodelling Through the AMPK Pathway. [Abstract]2025 Mar;29(5):e70488. PMID: 40070049 -
J Cell Mol Med
Sinomenine Ameliorated Microglial Activation and Neuropathic Pain After Chronic Constriction Injury Via TGF-β1/ALK5/Smad3 Signalling Pathway. [Abstract]2024 Nov;28(22):e70214. PMID: 39586784 -
Oncol Rep
Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer. [Abstract]2022 Oct;48(4):169. PMID: 35920185 -
Oncol Res
Analysis of the role of dihydromyricetin derived from vine tea (Ampelopsis grossedentata) on multiple myeloma by activating STAT1/RIG-I axis. [Abstract]2024 Jul 17;32(8):1359-1368. PMID: 39055888 -
Structure
Triangulating variation in the population to define mechanisms for precision management of genetic disease. [Abstract]2022 Aug 4;30(8):1190-1207.e5. PMID: 35714602 -
Biosci Rep
Isoprenaline alleviates diabetic kidney disease via multi-target inhibition of the cGAS-STING pathway. [Abstract]2026 May 20;46(5):BSR20250174. PMID: 41795784 -
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Poult Sci
Three alternative promoters govern PGC-1α expression in chicken and are directly repressed by PPARγ. [Abstract]2026 Jan 18;105(4):106481. PMID: 41610606 -
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Clin Exp Med
Donafenib activates the p53 signaling pathway in hepatocellular carcinoma, induces ferroptosis, and enhances cell apoptosis. [Abstract]2025 Jan 3;25(1):29. PMID: 39753901 -
Brain Res Bull
Hsa_circ_0049472 contributed to amyloid-beta peptide-induced neurotoxicity, apoptosis and inflammation via regulating PI3K-AKT signaling pathway by interacting with miR-22-3p/ZNF217 axis. [Abstract]2024 Sep:215:111004. PMID: 38852653 -
iScience
Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts. [Abstract]2024 Jun 28;27(7):110415. PMID: 39100925 -
iScience
StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR- c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. [Abstract]2024 Apr 6;27(5):109682. PMID: 38660403 -
iScience
Circ-CIMIRC inhibition alleviates CIH-induced myocardial damage via FbxL4-mediated ubiquitination of PINK1. [Abstract]2024 Jan 20;27(2):108982. PMID: 38333696 -
iScience
TBX15 facilitates malignant progression of glioma by transcriptional activation of TXDNC5. [Abstract]2024 Jan 18;27(2):108950. PMID: 38327797 -
iScience
OGT/HIF-2α axis promotes the progression of clear cell renal cell carcinoma and regulates its sensitivity to ferroptosis. [Abstract]2023 Oct 5;26(11):108148. PMID: 37915611 -
iScience
Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation. [Abstract]2023 May 9;26(6):106852. PMID: 37250786 -
ACS Chem Neurosci
Mitochondrial Inhibitor Rotenone Triggers and Enhances Neuronal Ferroptosis Following Intracerebral Hemorrhage. [Abstract]2023 Mar 15;14(6):1071-1079. PMID: 36848438 -
Biochim Biophys Acta Mol Cell Res
Development of a TEAD-independent reporter system for specific and sensitive measurement of YAP/TAZ activity. [Abstract]2026 Mar;1873(3):120111. PMID: 41534572 -
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Biochim Biophys Acta Mol Cell Res
MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 associated mitochondrial quality control. [Abstract]2025 Mar;1872(3):119911. PMID: 39880131 -
Mol Hum Reprod
Eutopic macrophages facilitate endometriosis progression via ferroptosis-mediated release of S100A9. [Abstract]2025 Apr 3;31(2):gaaf027. PMID: 40493892 -
Front Biosci (Landmark Ed)
2026 May 22;31(5):49658. PMID: 42216530 -
J Virol
ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5. [Abstract]2025 Sep 8:e0086825. PMID: 40919930 -
J Biol Chem
Mechanistic differences in eukaryotic initiation factor requirements for eIF4GI-driven cap-independent translation of structured mRNAs. [Abstract]2024 Nov;300(11):107866. PMID: 39384039 -
Hematol Oncol
2024 Sep;42(5):e3305. PMID: 39205619 -
Front Biosci (Landmark Ed)
Cisplatin Disrupts Proteasome Bounce-Back Effect through Suppressing ZEB1/Nfe2l1 in Cholangiocarcinoma. [Abstract]2024 Mar 15;29(3):106. PMID: 38538281 -
Clin Immunol
2023 Nov:256:109778. PMID: 37730009 -
Naunyn Schmiedebergs Arch Pharmacol
Quercetin inhibits glycolysis and tumor progression in a cell line-dependent manner, involving PI3K/AKT signaling predominantly in HOS cells. [Abstract]2026 Jan 29. PMID: 41609854 -
PLoS Genet
Genetic dissection of signalling pathways that mediate iron-related tumor growth in a Drosophila model. [Abstract]2026 Feb 13;22(2):e1012017. PMID: 41686790 -
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JOR Spine
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy. [Abstract]2024 Apr 17;7(2):e1325. PMID: 38633661 -
Food Sci Biotechnol
Enhancement of the bioactive compounds and biological activities of maca (Lepidium meyenii) via solid-state fermentation with Rhizopus oligosporus. [Abstract]2024 Feb 12;33(11):2585-2596. PMID: 39144202 -
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Am J Physiol Lung Cell Mol Physiol
Intrauterine inflammation-induced neonatal lung injury via succinic acid-mediated alveolar epithelial E-cadherin downregulation. [Abstract]2025 Aug 1;329(2):L282-L295. PMID: 40643013 -
Biochim Biophys Acta Mol Cell Biol Lipids
PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol. [Abstract]2022 Dec;1867(12):159217. PMID: 35985474 -
Mol Immunol
Formononetin in Jiawei Qihuangyin inhibits podocyte epithelial-mesenchymal transition and ameliorates diabetic nephropathy via SIRT1/NF-κB axis. [Abstract]2026 Feb:190:1-10. PMID: 41483656 -
J Pharm Pharmacol
Thymol suppressed tumor growth in vitro and in vivo through inducing calcium overload in colorectal cancer. [Abstract]2025 Sep 4;77(9):1264-1276. PMID: 40481655 -
Mol Immunol
Shikonin hastens diabetic wound healing by inhibiting M1 macrophage polarisation through the MAPK signaling pathway. [Abstract]2024 Dec 25:177:73-84. PMID: 39724782 -
Cell Transplant
Celecoxib Synergistically Enhances MLN4924-Induced Cytotoxicity and EMT Inhibition Via AKT and ERK Pathways in Human Urothelial Carcinoma. [Abstract]2022 Jan-Dec:31:9636897221077921. PMID: 35176901 -
J Biochem Mol Toxicol
Ononin Inhibits the Growth and Metastasis of Hepatocellular Carcinoma by Suppressing MMP-2 and MMP-9 via PI3K/AKT/mTOR Signaling. [Abstract]2026 Apr;40(4):e70804. PMID: 41878835 -
J Biochem Mol Toxicol
Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [Abstract]2026 Feb;40(2):e70701. PMID: 41560421 -
ACS Chem Biol
2025 Feb 21;20(2):464-478. PMID: 39818722 -
Toxicol Appl Pharmacol
The skin photoprotective effect of trilinolein: Induction of cellular autophagy via the AMPK-mTOR signaling pathway. [Abstract]2024 Feb:483:116836. PMID: 38272316 -
Exp Cell Res
Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-β1/smad and Hippo/YAP1 pathways. [Abstract]2024 Aug 22;442(1):114218. PMID: 39178981 -
Exp Cell Res
Low PDE4A expression promoted the progression of ovarian cancer by inducing Snail nuclear translocation. [Abstract]2024 Jun 15;439(2):114100. PMID: 38797258 -
Hum Exp Toxicol
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway. [Abstract]Jan-Dec 2022;41:9603271221087146. PMID: 35331031 -
Animal Model Exp Med
Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity. [Abstract]2025 Nov 11. PMID: 41216763 -
Toxicol Res
miR-143-3p mediates mercury chloride-induced neurotoxicity by targeting LMO4 and the Akt/GSK3β/mTOR pathway in vitro. [Abstract]2025 Sep 1;42(1):19-34. PMID: 41503443 -
Chem Biol Drug Des
Polyphyllin VII Enhances the Sensitivity of Prostate Cancer Cells to Docetaxel by Promoting Mitochondrial Dysfunction and Inducing Ferroptosis. [Abstract]2025 Feb;105(2):e70053. PMID: 39871642 -
Chem Biol Drug Des
Praeruptorin A inhibits the activation of NF-κB pathway and the expressions of inflammatory factors in poly (I:C)-induced RAW264.7 cells. [Abstract]2023 Nov;102(5):1110-1120. PMID: 37500542 -
Mol Biol Rep
2024 Mar 27;51(1):453. PMID: 38536553 -
Animals (Basel)
NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition. [Abstract]2024 Feb 9;14(4):585. PMID: 38396553 -
Neuropsychiatr Dis Treat
VRT-043198 Ameliorates Surgery-Induced Neurocognitive Disorders by Restoring the NGF and BNDF Expression in Aged Mice. [Abstract]2022 May 16:18:1027-1037. PMID: 35607505 -
Exp Eye Res
Apigenin attenuates LPS-induced corneal inflammation by modulating NF-κB and JNK/ERK signaling pathways. [Abstract]2026 May:266:110900. PMID: 41651439 -
Exp Eye Res
Proanthocyanidins inhibit the inflammation response of dry eye by regulating IRAK4/JAK1/STAT1 signaling pathway. [Abstract]2026 May:266:110936. PMID: 41724228 -
Tissue Cell
Targeting YBX1: A novel therapeutic strategy for gastric cancer through regulation of cellular senescence and mTOR signaling. [Abstract]2025 Dec:97:103089. PMID: 40834829 -
Exp Eye Res
2025 Oct:259:110509. PMID: 40633646 -
FEBS Lett
Identification of novel anti-leishmanials targeting glutathione synthetase of the parasite: a drug repurposing approach. [Abstract]2025 Feb;599(3):367-380. PMID: 39266470 -
Genes (Basel)
Unveiling the Mechanism of Compound Ku-Shen Injection in Liver Cancer Treatment through an Ingredient-Target Network Analysis. [Abstract]2024 Sep 29;15(10):1278. PMID: 39457402 -
Kaohsiung J Med Sci
Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis. [Abstract]2022 Apr;38(4):367-377. PMID: 34962339 -
JBMR Plus
Inhibition of FGFR signaling with infigratinib improves linear bone growth in the female Aga2/+ mouse model of osteogenesis imperfecta. [Abstract]2026 Jan 14;10(3):ziag005. PMID: 41641077 -
Cell Biochem Biophys
2025 Mar;83(1):647-656. PMID: 39673685 -
Front Cardiovasc Med
GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis. [Abstract]2022 Jun 2;9:907747. PMID: 35722096 -
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Dig Dis Sci
IL-17/IL-17RA Axis Facilitates Immune Evasion in Hepatocellular Carcinoma by Upregulating PD-L1 via the NF-κB Pathway. [Abstract]2026 Jun 24. PMID: 42340520 -
Vet Microbiol
Sec6 suppresses BEFV-triggered type I IFN responses by promoting P62-mediated MAVS degradation. [Abstract]2025 Sep:308:110658. PMID: 40780029 -
Gene
LncRNA GAS5 regulates apoptosis in ovarian cancer cells by regulating O-GlcNAcylation of GOLGA8B. [Abstract]2026 May 15:991:150084. PMID: 41791436 -
Clin Transl Oncol
Silencing of MAT2A inhibits gastric cancer cell proliferation, migration, and invasion through activation of the p53 pathway. [Abstract]2025 Dec 19. PMID: 41419675 -
Toxicol In Vitro
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway. [Abstract]2023 Sep:91:105626. PMID: 37286014 -
Technol Cancer Res Treat
Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity. [Abstract]Jan-Dec 2022;21:15330338221085361. PMID: 35369814 -
Hereditas
MiR-518c-5p/miR-4524a-3p can mediate immune escape and chemotherapy resistance in triple-negative breast cancer and predict its outcome. [Abstract]2025 Oct 21;162(1):216. PMID: 41121425 -
J Mol Histol
Mechanism of METTL14 regulates HBV-HCC malignant progression by mediating m6A modification of FOXP3 and thus transcriptional activation of ALDOB. [Abstract]2025 Aug 8;56(4):259. PMID: 40778958 -
Clin Med Insights Oncol
MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells. [Abstract]2024 Apr 15:18:11795549241244783. PMID: 38628842 -
J Chem Neuroanat
Solifenacin promotes remyelination in cuprizone mouse model by inhibiting the Wnt/β-catenin signaling pathway. [Abstract]2024 Mar:136:102375. PMID: 38123002 -
Virology
Evaluating anti-viral effect of Ivermectin on porcine epidemic diarrhea virus and analyzing the related genes and signaling pathway by RNA-seq in vitro. [Abstract]2023 Oct:587:109877. PMID: 37688922 -
Arch Dermatol Res
Tangeretin regulates oxidative stress in cutaneous melanoma cells via the Nrf2 signaling pathway. [Abstract]2025 Mar 12;317(1):550. PMID: 40072600 -
Biochem Biophys Res Commun
Andrographolide promotes lymphangiogenesis and lymphatic vessel remodeling to alleviate secondary lymphedema. [Abstract]2024 Sep 3:723:150179. PMID: 38820623 -
Cancer Chemother Pharmacol
Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells. [Abstract]2024 Jan;93(1):41-54. PMID: 37741955 -
Biochem Biophys Res Commun
Estrogen ameliorates sepsis-induced vascular hyporeactivity in thoracic aorta of female rats via permissive effect of GRα expression. [Abstract]2023 May 21:657:108-118. PMID: 37002984 -
Sex Med
Hinokiflavone alleviates high-fat diet-induced erectile dysfunction via the EGFR/PI3K/Akt/eNOS signaling pathway. [Abstract]2025 Aug 6;13(4):qfaf059. PMID: 40808867 -
Biotechnol Genet Eng Rev
LncRNA MBNL1-AS1 knockdown increases the sensitivity of hepatocellular carcinoma to tripterine by regulating miR-708-5p-mediated glycolysis. [Abstract]2024 Nov;40(3):1407-1424. PMID: 36951619 -
Mutat Res
NTSR1 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma through the Wnt/β-catenin pathway. [Abstract]2024 Jul-Dec:829:111877. PMID: 39180939 -
J Mol Neurosci
The Prevention and Reversal of a Phenytoin-Resistant Model by N-acetylcysteine Therapy Involves the Nrf2/P-Glycoprotein Pathway at the Blood-Brain Barrier. [Abstract]2022 Oct;72(10):2125-2135. PMID: 36028602 -
Ann Hematol
GANT61 suppresses proliferation and induces apoptosis in ALK-Positive anaplastic large cell lymphoma via modulating the Hh-PIK3IP1-Akt signaling axis. [Abstract]2026 Jan 23;105(2):54. PMID: 41571844 -
Ann Hematol
TGFBI regulates the TGF-β pathway to affect the malignant progression and cisplatin sensitivity in diffuse large B-cell lymphoma. [Abstract]2025 Feb;104(2):1165-1176. PMID: 39856252 -
Transl Cancer Res
Liriopesides B inhibits proliferation and metastasis and induces apoptosis of oral squamous cell carcinoma via the PI3K/Akt/mTOR signaling pathway. [Abstract]2025 Oct 31;14(10):6637-6652. PMID: 41234828 -
J Radiat Res
Radiation-induced NF-κB activation is involved in cochlear damage in mice via promotion of a local inflammatory response. [Abstract]2023 Jan 20;64(1):63-72. PMID: 36253086 -
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Comput Methods Biomech Biomed Engin
Developing a diagnostic model for necroptosis in osteoporosis using bioinformatics and machine learning. [Abstract]2025 Dec 10:1-16. PMID: 41370854 -
Biochem Genet
TRIM8 Promotes Proliferation, Invasion, and Migration of Cervical Cancer Cells by Ubiquitinating and Degrading SOCS1. [Abstract]2025 Aug;63(4):3206-3219. PMID: 38918306 -
Biochem Genet
Myricetin Restores Autophagy to Attenuate Lumbar Intervertebral Disk Degeneration Via Negative Regulation of the JAK2/STAT3 Pathway. [Abstract]2025 Jun;63(3):2743-2759. PMID: 38842745 -
Folia Histochem Cytobiol
Nintedanib alleviates hyperoxia-induced lung injury via targeting NF-κB signalling pathway in rat model of bronchopulmonary dysplasia. [Abstract]2025;63(2):79-87. PMID: 40421818 -
Connect Tissue Res
Neferine alleviates ovariectomy-induced osteoporosis by enhancing osteogenic differentiation of bone marrow mesenchymal stem cells via regulation of the p38MAPK pathway. [Abstract]2024 May;65(3):253-264. PMID: 38753365 -
Eur J Histochem
Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway. [Abstract]2023 Mar 20;67(2):3639. PMID: 36951266 -
Protein Expr Purif
Biochemical characterization of histidinol dehydrogenase from the human pathogen Neisseriagonorrhoeae. [Abstract]2025 Sep 26:106824. PMID: 41016688 -
Rejuvenation Res
Resveratrol Inhibits Pancreatic Cancer Progression by Regulating CDC42 Succinylation and Disrupting the Extracellular Matrix. [Abstract]2025 Sep 18. PMID: 40965218 -
Brain Dev
L-NAME improves the morphology and necrosis of skeletal muscle by activating PINK1-PARKIN mediated mitophagy in mdx mice. [Abstract]2025 Jul 1;47(4):104388. PMID: 40602311 -
Reprod Domest Anim
6-Gingerol and Astaxanthin Mitigate the Effects of Stearic Acid in Pig Oocyte Maturation. [Abstract]2024 Nov;59(11):e14746. PMID: 39582146 -
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Acta Cir Bras
2025 Aug 18:40:e406825. PMID: 40834223 -
J Cardiothorac Surg
Protective role of FBXL19 in Streptococcus pneumoniae-induced lung injury in pneumonia immature mice. [Abstract]2023 Mar 24;18(1):92. PMID: 36964598 -
Biosci Biotechnol Biochem
Kangfuxin liquid reduces the ultraviolet B-induced photodamage of HaCaT cells by regulating autophagy. [Abstract]2023 Nov 21;87(12):1485-1494. PMID: 37682519 -
J Cancer Res Ther
Inhibition of MDM2 by nutlin-3 decreased pyroptosis but increased apoptosis of lung carcinoma cells under 5-FU chemotherapy. [Abstract]2025 Dec 1;21(6):1186-1197. PMID: 41452010 -
Vascular
Exploration of small molecule compounds targeting abdominal aortic aneurysm based on CMap database and molecular dynamics simulation. [Abstract]2024 Aug 18:17085381241273289. PMID: 39155144 -
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Environ Sci Pollut Res Int
Nanostructured copper-organic frameworks for the generation of sulphate radicals: application in wastewater disinfection. [Abstract]2025 Apr;32(16):10490-10504. PMID: 37670094 -
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Biomed Pharmacother
Design, synthesis and biological evaluation of dual inhibitors targeting AR/AR-Vs and PARP1 in castration resistant prostate cancer therapy. [Abstract]2024 Nov:180:117485. PMID: 39326103 -
bioRxiv
2024 Oct 7:2024.09.26.615278. PMID: 39386436 -
bioRxiv
2024 Aug 6:2024.03.21.586169. PMID: 38586030 -
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Biomed Pharmacother
Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis. [Abstract]2024 Apr:173:116425. PMID: 38490155 -
Biomed Pharmacother
Sakuranetin reduces inflammation and chondrocyte dysfunction in osteoarthritis by inhibiting the PI3K/AKT/NF-κB pathway. [Abstract]2024 Feb:171:116194. PMID: 38262147 -
bioRxiv
Label-Free, Real-Time Monitoring of Cytochrome C Responses to Drugs in Microdissected Tumor Biopsies with a Multi-Well Aptasensor Platform. [Abstract]2024 Feb 1:2024.01.31.578278. PMID: 38352494 -
Sci Total Environ
PPARβ/δ-ANGPTL4 axis mediates the promotion of mono-2-ethylhexyl phthalic acid on MYCN-amplified neuroblastoma development. [Abstract]2024 Feb 20:912:168949. PMID: 38042186 -
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Biomed Pharmacother
Toxic effects of sirolimus and everolimus on the development and behavior of zebrafish embryos. [Abstract]2023 Oct:166:115397. PMID: 37659200 -
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J Oncol
Computational Drug Repurposing Approach to Identify Novel Inhibitors of ILK Protein for Treatment of Esophageal Squamous Cell Carcinoma. [Abstract]2022 Dec 29:2022:3658334. PMID: 36618074 -
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Heliyon
Upregulated influenza A viral entry factors and enhanced interferon-alpha response in the nasal epithelium of pregnant rats. [Abstract]2022 May 11;8(5):e09407. PMID: 35592667 -
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
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Data Sheet (277 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
References
[1]. C F Brayton. Dimethyl sulfoxide (DMSO): a review. Cornell Vet. 1986 Jan;76(1):61-90. [Content Brief]
[2]. William F Rawls, et al. Dimethyl sulfoxide (DMSO) as intravesical therapy for interstitial cystitis/bladder pain syndrome: A review. Neurourol Urodyn. 2017 Sep;36(7):1677-1684. [Content Brief]
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Dimethyl sulfoxide, meets analytical specification of Ch.P. Related Classifications
HY-Y0320 Related Classifications
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