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    Metabolic Enzyme/Protease
  2. Estrogen Receptor/ERR
    Endogenous Metabolite
  3. Estradiol

Estradiol (Synonyms: β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol)

Cat. No.: HY-B0141 Purity: 99.99%
Handling Instructions

Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.

For research use only. We do not sell to patients.

Estradiol Chemical Structure

Estradiol Chemical Structure

CAS No. : 50-28-2

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10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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Estimated Time of Arrival: December 31
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1 g USD 66 In-stock
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Based on 27 publication(s) in Google Scholar

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Description

Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Estradiol (10 nM, 7 days) induces neural differentiation and increased neurite branching of human endometrial stem cells (hEnSCs)[1].
Estradiol (17β-estradiol, 10 nM, 7 days) increases the expression of neuron-like cell markers (Tuj-1, nestin and NF-H) in neural-like cells differentiated from hEnSCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[1]

Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue
Concentration: 10 nM
Incubation Time: 7 days
Result: Increased the number of neurite processes including neural differentiation and neurite branching.

Immunofluorescence[1]

Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue
Concentration: 10 nM
Incubation Time: 7 days
Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.
In Vivo

Estradiol (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1].
Estradiol (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FBN-ARO-KO Mice[2]
Dosage: 1 nM
Administration: Treated for the hippocampal slices
Result: Rescued long-term potentiation (LTP) amplitude of both male and female mice.
Animal Model: FBN-ARO-KO Mice[2]
Dosage: 0.0167 mg
Administration: Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.
Result: Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain.
Rescued the spatial learning and memory defects.
Clinical Trial
Molecular Weight

272.38

Formula

C18H24O2

CAS No.
SMILES

C[[email protected]@]1([[email protected]]2O)[[email protected]](CC2)([H])[[email protected]@](CCC3=C4C=CC(O)=C3)([H])[[email protected]]4([H])CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (183.57 mM)

Ethanol : 20 mg/mL (73.43 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6713 mL 18.3567 mL 36.7134 mL
5 mM 0.7343 mL 3.6713 mL 7.3427 mL
10 mM 0.3671 mL 1.8357 mL 3.6713 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  corn oil

    Solubility: 12.5 mg/mL (45.89 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

  • 5.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: 2.5 mg/mL (9.18 mM); Suspended solution; Need ultrasonic

  • 6.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.99%

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Product Name:
Estradiol
Cat. No.:
HY-B0141
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