A novel estrogen receptor ligand template

  • Bioorg Med Chem Lett. 2003 Jun 2;13(11):1919-22. doi: 10.1016/s0960-894x(03)00307-x.
Robert Sibley  1 ,  Holia Hatoum-Mokdad ,  Robert Schoenleber ,  Laszlo Musza ,  William Stirtan ,  Diana Marrero ,  William Carley ,  Hong Xiao ,  Jacques Dumas
Affiliations
  • 1. Bayer Research Center, Bayer Corporation, Pharmaceutical Division, 400 Morgan Lane, West Haven, CT 06516, USA. [email protected]
PMID: 12749898 DOI: 10.1016/s0960-894x(03)00307-x
Abstract

Three synthetic routes towards a novel Estrogen receptor ligand template based on a rigid bicyclo-[3.3.1]-nonene core have been investigated. The prototype compound exhibits potent binding at the ERbeta receptor and promising Estrogen receptor subtype selectivity.