ent-Estradiol
Ent-Estradiol is the enantiomer of Estradiol (HY-B0141). Ent-Estradiol is a highly selective estrogen receptor ligand, but does not possess estrogenic activity. Ent-Estradiol displays IC50 values of 24.9 nM, 9.59 nM and 8.17 nM for human, rat and mouse ERβ, and 151 nM, 246 nM and 268 nM for human, rat and mouse ERα, respectively. Ent-Estradiol can be used for the study of menopausal physiological changes.
For research use only. We do not sell to patients.
- CAS No.: 3736-22-9
- Formula: C18H24O2
- Molecular Weight:272.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hERα 151 nM (IC50) |
mouse ERα 268 nM (IC50) |
rat ERα 246 nM (IC50) |
hERβ 24.9 nM (IC50) |
rat ERβ 9.59 nM (IC50) |
mouse ERβ 8.17 nM (IC50) |
Ent-Estradiol (eight dilutions; 5-18 h) selectively binds to ER-β over ER-α across human, rat, and mouse receptors, with the highest selectivity observed for mouse ER-β, and exhibits IC50 values of 24.9 nM (human ER-β), 9.59 nM (rat ER-β), 8.17 nM (mouse ER-β), 151 nM (human ER-α), 246 nM (rat ER-α), and 268 nM (mouse ER-α)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3736-22-9
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Molecular Weight 272.38
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Formula C18H24O2
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SMILES
C[C@]12[C@@](CC[C@H]2O)([H])[C@]3([H])[C@](CC1)([H])C4=CC=C(O)C=C4CC3
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Synonyms
ent-β-Estradiol; ent-17β-Estradiol; ent-17β-Oestradiol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ent-Estradiol Related Classifications
HY-B0141E Related Classifications
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