2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ent-Estradiol

ent-Estradiol  (Synonyms: ent-β-Estradiol; ent-17β-Estradiol; ent-17β-Oestradiol)

Cat. No.: HY-B0141E
Handling Instructions Technical Support

Ent-Estradiol is the enantiomer of Estradiol (HY-B0141). Ent-Estradiol is a highly selective estrogen receptor ligand, but does not possess estrogenic activity. Ent-Estradiol displays IC50 values of 24.9 nM, 9.59 nM and 8.17 nM for human, rat and mouse ERβ, and 151 nM, 246 nM and 268 nM for human, rat and mouse ERα, respectively. Ent-Estradiol can be used for the study of menopausal physiological changes.

For research use only. We do not sell to patients.

ent-Estradiol

ent-Estradiol Chemical Structure

CAS No. : 3736-22-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of ent-Estradiol:

ent-Estradiol Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ent-Estradiol is the enantiomer of Estradiol (HY-B0141). Ent-Estradiol is a highly selective estrogen receptor ligand, but does not possess estrogenic activity. Ent-Estradiol displays IC50 values of 24.9 nM, 9.59 nM and 8.17 nM for human, rat and mouse ERβ, and 151 nM, 246 nM and 268 nM for human, rat and mouse ERα, respectively. Ent-Estradiol can be used for the study of menopausal physiological changes[1].

IC50 & Target

hERα

151 nM (IC50)

mouse ERα

268 nM (IC50)

rat ERα

246 nM (IC50)

hERβ

24.9 nM (IC50)

rat ERβ

9.59 nM (IC50)

mouse ERβ

8.17 nM (IC50)

In Vitro

Ent-Estradiol (eight dilutions; 5-18 h) selectively binds to ER-β over ER-α across human, rat, and mouse receptors, with the highest selectivity observed for mouse ER-β, and exhibits IC50 values of 24.9 nM (human ER-β), 9.59 nM (rat ER-β), 8.17 nM (mouse ER-β), 151 nM (human ER-α), 246 nM (rat ER-α), and 268 nM (mouse ER-α)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ent-Estradiol Related Antibodies
Molecular Weight

272.38

Formula

C18H24O2
CAS No.
SMILES

C[C@]12[C@@](CC[C@H]2O)([H])[C@]3([H])[C@](CC1)([H])C4=CC=C(O)C=C4CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ent-Estradiol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ent-Estradiol3736-22-9ent-β-Estradiol ent-17β-Estradiol ent-17β-OestradiolEstrogen Receptor/ERRrat receptorsER-βER-αhuman receptorsmouse receptorsestrogen receptor ligandInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ent-Estradiol
Cat. No.:
HY-B0141E
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.