ERα

By Type:	Pan (16) Selective (15)
By Effects:	Inhibitors (10) Agonists (5) Antagonists (10) Modulators (4) Chemical (1)

Cat. No.	Product Name	Effect	Purity

HY-14590

Kaempferol	Inhibitor	99.67%
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK.

HY-100689

Propyl pyrazole triol	Agonist	99.11%
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist.

HY-133017

Amcenestrant	Antagonist	99.59%
SAR439859 (compound 43d) is an orally active, nonsteroidal and selective estrogen receptor degrader (SERD).

HY-14933

Prinaberel	Agonist	98.05%
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC₅₀s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively.

HY-103454

MPP dihydrochloride	Modulator	99.06%
MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator.

HY-126109

(±)-8-Prenylnaringenin	Modulator
(±)-8-Prenylnaringenin, a natural prenylated flavonoid, is a potent phytoestrogen.

HY-112611

H3B-5942	Inhibitor	≥98.0%
H3B-5942 is a selective, irreversible and orally active estrogen receptor covalent antagonist, inactivates both wild-type and mutant ERα by targeting Cys530, with K_is of 1 nM and 0.41 nM, respectively.

HY-B1662

Hexestrol	Agonist	99.88%
Hexestrol is a nonsteroidal synthetic estrogen, with a K_i of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ.

HY-111846

PROTAC ERα Degrader-2	Inhibitor	98.88%
PROTAC ERα Degrader-2 comprises a IAP ligand binding group, a linker and an estrogen receptor α (ERα) binding group.

HY-119437

FLTX1	Inhibitor	99.71%
FLTX1 is a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-permeabilized conditions.

HY-16023

Acolbifene hydrochloride	Antagonist	98.48%
Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing selective estrogen receptor modulator (SERM).

HY-125263

OP-1074	Inhibitor	99.47%
OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD), shows specific antiestrogenic activity for ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC₅₀ of 1.6 and 3.2 nM, respectively.

HY-16023A

Acolbifene	Antagonist	98.86%
Acolbifene (EM-652), the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist.

HY-18719E

Endoxifen
Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity.

HY-103451

(R,R)-THC	Antagonist	≥99.0%
(R,R)-THC is an ERα agonist and an ERβ antagonist, with K_is of 9.0 nM and 3.6 nM for ERα and ERβ, respectively.

HY-103454B

MPP hydrochloride	Modulator	99.58%
MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator.

HY-132194

ERα degrader-2	Inhibitor	99.71%
ERα degrader-2 is a selective estrogen receptor degrader (SERD) with potent binding affinity with ERα (IC₅₀=17.1 nM), good degradation efficacy (EC₅₀=0.3 nM).

HY-145341

GNE-149	Antagonist
GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα; IC₅₀=0.053 nM).

HY-114411

ERRγ Inverse Agonist 1	Antagonist
ERRγ Inverse Agonist 1 (Compound 12) is a potent, selective and orally bioavailable Estrogen-related Receptor grammar (ERRγ) inverse agonist, with an IC₅₀ of 40 nM.

HY-146267

ERα degrader 5	Antagonist
ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC₅₀ of 1.1 nM against ERα.

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