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Smurf1-IN-A01 (Synonyms: A01)

Cat. No.: HY-110195 Purity: 99.58%
Handling Instructions

Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.

For research use only. We do not sell to patients.

Smurf1-IN-A01 Chemical Structure

Smurf1-IN-A01 Chemical Structure

CAS No. : 1007647-73-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 102 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 490 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1].

IC50 & Target

Kd: 3.664 nM (Smurf1)[1]

Clinical Trial
Molecular Weight

512.93

Formula

C₂₂H₂₀ClF₃N₄O₃S

CAS No.

1007647-73-5

SMILES

O=S(C1=CC(C(F)(F)F)=C(Cl)C=C1)(N2CCN(C(C3=CC=C(N4C(C)=CC=N4)C=C3)=O)CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (121.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9496 mL 9.7479 mL 19.4958 mL
5 mM 0.3899 mL 1.9496 mL 3.8992 mL
10 mM 0.1950 mL 0.9748 mL 1.9496 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Smurf1-IN-A01
Cat. No.:
HY-110195
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