MPP dihydrochloride
Based on 16 publication(s) in Google Scholar
MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo.
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 911295-24-4
- Formula: C29H33Cl2N3O3
- Molecular Weight:542.50
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) MPP dihydrochloride
More- Drug Resist Updat. 2023 Nov:71:101014. [Abstract]
- J Pharm Anal. 2025 Jul;15(7):101182. [Abstract]
- Phytomedicine. 2024 Jan:123:155218. [Abstract]
- Phytomedicine. 2022 May:99:154022. [Abstract]
- Ecotoxicol Environ Saf. 2023 Jul 1:259:115060. [Abstract]
- Cell Biol Toxicol. 2026 Feb 5;42(1):34. [Abstract]
- Biochem Pharmacol. 2025 Dec;242(Pt 4):117432. [Abstract]
- Biochem Pharmacol. 2024 May 9:225:116256. [Abstract]
- Biomolecules. 2023 Jul 10;13(7):1097. [Abstract]
- Mol Nutr Food Res. 2021 Sep;65(17):e2100070. [Abstract]
- Food Chem Toxicol. 2023 Jun:176:113792. [Abstract]
- Metab Brain Dis. 2022 Oct;37(7):2349-2362. [Abstract]
- J Pharm Pharmacol. 2026 Feb 7;78(2):rgag010. [Abstract]
- Biol Reprod. 2025 Jun 15;112(6):1114-1122. [Abstract]
- Brain Res. 2025 Dec 17:1873:150116. [Abstract]
- Eur J Inflamm. October 11, 2021.
Biological Activity
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ERα |
ERβ |
MPP (1, 5, 10, 25, 50 and 100 μM; 24 h) decreases cell viability with an IC50 value of 20.01 μM in RL95-2 cells[1].
MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells[1].
MPP dihydrochloride (20 μM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RL95-2 endometrium cancer cells
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Concentration:1, 5, 10, 25, 50 and 100 µM
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Incubation Time:24 hours
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Result:The treatment with 25 µM, 50 µM and 100 µM for 24 h decreased cell viability significantly. However, cell viability was not significantly changed by MPP dihydrochloride at concentration below 25 µM.
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Cell Line:RL95-2 cell
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Concentration:10, 15, 20 and 25 µM
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Incubation Time:72 hours
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Result:Showed antiproliferative activity at a concentration of 10 μM.
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Cell Line:RL95-2 cell line
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Concentration:20 µM
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Incubation Time:24 hours
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Result:Reduced the phosphorylation of ERα, while it did not alter the phosphorylation of Akt. Reduced the ratio of p-ERα/ERα compared to the control group.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6N mice at the age of 9-10 weeks[2]
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Dosage:Low dose (20 μg/kg body weight) or high dose (200 μg/kg body weight)
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Administration:Administered subcutaneously (s.c.) injected; injection volume of 5 mL/kg; 60 min before PPI testing
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Result:Led to a dose-dependent attenuation of percent PPI. Pretreatment with 200 μg/kg reduced the mean percent PPI scores by ~30%.
Chemical Information
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CAS No. 911295-24-4
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Appearance Solid
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Molecular Weight 542.50
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Formula C29H33Cl2N3O3
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Color White to off-white
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SMILES
OC1=CC=C(C2=NN(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)=C2C)C=C1.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (16)
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Journal Impact Factor
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Most Recent
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Drug Resist Updat
Cisplatin-activated ERβ/DCAF8 positive feedback loop induces chemoresistance in non-small cell lung cancer via PTEN/Akt axis. [Abstract]2023 Nov:71:101014. PMID: 37913652 -
J Pharm Anal
Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury. [Abstract]2025 Jul;15(7):101182. PMID: 40735031 -
Phytomedicine
Effects and mechanisms of frehmaglutin D and rehmaionoside C improve LPS-induced acute kidney injury through the estrogen receptor-mediated TLR4 pathway in vivo and in vitro. [Abstract]2024 Jan:123:155218. PMID: 37980806 -
Phytomedicine
Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism. [Abstract]2022 May:99:154022. PMID: 35255283 -
Ecotoxicol Environ Saf
Bisphenol A interferes with lncRNA Fhadlos2 and RUNX3 association in adolescent mouse ovary. [Abstract]2023 Jul 1:259:115060. PMID: 37229876 -
Cell Biol Toxicol
HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity. [Abstract]2026 Feb 5;42(1):34. PMID: 41639490 -
Biochem Pharmacol
Formononetin alleviates corticosterone-induced myelin damage through activating ERα and promoting the differentiation of oligodendrocyte precursor cells in the prefrontal cortex. [Abstract]2025 Dec;242(Pt 4):117432. PMID: 41110491 -
Biochem Pharmacol
MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway. [Abstract]2024 May 9:225:116256. PMID: 38729448 -
Biomolecules
Active Estrogen-Succinate Metabolism Promotes Heme Accumulation and Increases the Proliferative and Invasive Potential of Endometrial Cancer Cells. [Abstract]2023 Jul 10;13(7):1097. PMID: 37509133 -
Mol Nutr Food Res
Diosmetin Protects Against Obesity and Metabolic Dysfunctions Through Activation of Adipose Estrogen Receptors in Mice. [Abstract]2021 Sep;65(17):e2100070. PMID: 34223710 -
Food Chem Toxicol
BPA exposure enhances the metastatic aggression of ovarian cancer through the ERα/AKT/mTOR/HIF-1α signaling axis. [Abstract]2023 Jun:176:113792. PMID: 37080528 -
Metab Brain Dis
A novel LINC00943/miR-671-5p/ELAVL1 ceRNA crosstalk regulates MPP+ toxicity in SK-N-SH cells. [Abstract]2022 Oct;37(7):2349-2362. PMID: 35779150 -
J Pharm Pharmacol
Formononetin attenuates corticosterone-induced depressive-like behaviors and neuronal damage via ERα/ERK-CREB-BDNF signaling pathway. [Abstract]2026 Feb 7;78(2):rgag010. PMID: 41697882 -
Biol Reprod
SRA deficiency induces follicular dysplasia by disrupting the hypothalamic Kisspeptin-GPR54 system in mice. [Abstract]2025 Jun 15;112(6):1114-1122. PMID: 40057968 -
Brain Res
Ezetimibe mitigates microglial activation in Parkinson's disease via TLR4/JNK pathway inhibition: evidence from network pharmacology and experimental validation. [Abstract]2025 Dec 17:1873:150116. PMID: 41419122 -
Solvent & Solubility
DMSO : 30 mg/mL (55.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Karaboğa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients. 2018 May 25;10(6). pii: E672. [Content Brief]
[2]. Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94. [Content Brief]
[3]. Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73(8):1034-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8433 mL | 9.2166 mL | 18.4332 mL | 46.0829 mL |
| 5 mM | 0.3687 mL | 1.8433 mL | 3.6866 mL | 9.2166 mL | |
| 10 mM | 0.1843 mL | 0.9217 mL | 1.8433 mL | 4.6083 mL | |
| 15 mM | 0.1229 mL | 0.6144 mL | 1.2289 mL | 3.0722 mL | |
| 20 mM | 0.0922 mL | 0.4608 mL | 0.9217 mL | 2.3041 mL | |
| 25 mM | 0.0737 mL | 0.3687 mL | 0.7373 mL | 1.8433 mL | |
| 30 mM | 0.0614 mL | 0.3072 mL | 0.6144 mL | 1.5361 mL | |
| 40 mM | 0.0461 mL | 0.2304 mL | 0.4608 mL | 1.1521 mL | |
| 50 mM | 0.0369 mL | 0.1843 mL | 0.3687 mL | 0.9217 mL |
MPP dihydrochloride Related Classifications
HY-103454 Related Classifications
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