2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Hexestrol

Hexestrol 

Cat. No.: HY-B1662 Purity: 99.89%
COA Handling Instructions

Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle.

For research use only. We do not sell to patients.

Hexestrol Chemical Structure

Hexestrol Chemical Structure

CAS No. : 84-16-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid
50 mg USD 55 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Hexestrol:

Hexestrol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Hexestrol

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle[1][2][3].

IC50 & Target[3]

ERα

0.06 nM (Ki)

ERβ

0.06 nM (Ki)

In Vivo

Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mus musculus (90-120 days, 25-50 g)[2]
Dosage: 3, 6 mg/kg (adopted the same dose used to increase weight gain in cattle)
Administration: I.p. once daily for 30 days
Result: Numerous follicles in different stages of development were found at the dose of 3 mg/kg in the ovaries.
Not detected the corpora lutea (CL) at the dose of 6 mg/kg.
Molecular Weight

270.37

Appearance

Solid

Formula

C18H22O2
CAS No.
SMILES

CC[C@H](C1=CC=C(O)C=C1)[C@H](C2=CC=C(O)C=C2)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (369.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6986 mL 18.4932 mL 36.9864 mL
5 mM 0.7397 mL 3.6986 mL 7.3973 mL
10 mM 0.3699 mL 1.8493 mL 3.6986 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.08 mg/mL (7.69 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (7.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (7.69 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

COA (246 KB) RP-HPLC (88 KB)

Handling Instructions (2659 KB)
References
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Hexestrol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Hexestrol84-16-2Estrogen Receptor/ERRnonsteroidalsyntheticestrogenInhibitorinhibitorinhibit

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