84-16-2
84-16-2
Chemical Structure
Hexestrol
- CAS No.: 84-16-2
- Formula:C18H22O2
- Molecular Weight:270.37
IUPAC Name: 4,4'-((3R,4S)-hexane-3,4-diyl)diphenol
InChIKey: PBBGSZCBWVPOOL-HDICACEKSA-N
SMILES: CC[C@H](C1=CC=C(O)C=C1)[C@H](C2=CC=C(O)C=C2)CC
Biological Activity: Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Hexestrol | 99.79% | Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Hexestrol (Standard) | ≥98% | Hexestrol (Standard) is the analytical standard of Hexestrol. This product is intended for research and analytical applications. Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Hexestrol-d4 | 97.49% | Hexestrol-d4 is the deuterium labeled Hexestrol (HY-B1662). Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(Rac)-Hexestrol-d6-1 | (Rac)-Hexestrol-d6-1 is the deuterium labeled (Rac)-Hexestrol (HY-W354544). (Rac)-Hexestrol is the racemic form of Hexestrol (HY-B1662). Hexestrol is a synthetic non-steroidal estrogen. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(Rac)-Hexestrol-d6 | (Rac)-Hexestrol-d6 is the deuterium labeled (Rac)-Hexestrol. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(R)-DPN | (R)-DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R)-DPN shows a very high affinity and potency preference for ERβ over ERα. (R)-DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
DPN (Standard) | ≥98% | DPN (Standard) is the analytical standard of DPN. This product is intended for research and analytical applications. DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Terfluranol | Terfluranol is a bibenzyl derivative. Terfluranol is an antineoplastic agent. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Metahexestrol | Metahexestrol is an estrogen receptor (E2R) inhibitor with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cells (ED50 = 1.0 μM). Additionally, Metahexestrol also exhibits inhibitory effects in estrogen receptor-negative MDA-MB-231 cells, and its antiproliferative activity cannot be reversed by estrogen, suggesting that its mechanism of action may be partially independent of the E2R pathway. Metahexestrol can be used in research on estrogen-dependent breast cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(Rac)-Hexestrol-d4 | (Rac)-Hexestrol-d4 is the deuterium labeled (Rac)-Hexestrol. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Bisphenol B (Standard) | ≥98% | Bisphenol B (Standard) is the analytical standard of Bisphenol B. This product is intended for research and analytical applications. Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC50 = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Bisphenol E | 99.90% | Bisphenol E (4,4'-Ethylidenediphenol) is a biochemical reagent. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(Rac)-Hexestrol | (Rac)-Hexestrol is the racemic form of Hexestrol (HY-B1662). Hexestrol is a synthetic non-steroidal estrogen. (Rac)-Hexestrol usually appears in deuterated form and is used as an internal standard for precise quantitative analysis in analytical chemistry. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. HARDING FE, et, al. The oral use of hexestrol for estrogen deficiency. Am J Obstet Gynecol. 1946 May; 51: 660-5. [Content Brief]
- [2]. Oliveira JM, et, al. Effects of hexestrol on mouse ovarian morphology and ovulation. Maturitas. 2008 Jun 20; 60(2): 153-7. [Content Brief]
- [3]. Kuiper GG, et, al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997 Mar;138(3):863-70. [Content Brief]
