263717-53-9
263717-53-9
Chemical Structure
Propyl pyrazole triol
Synonym(s): PPT
- CAS No.: 263717-53-9
- Formula:C24H22N2O3
- Molecular Weight:386.44
IUPAC Name: 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)triphenol
InChIKey: IOTXSIGGFRQYKW-UHFFFAOYSA-N
SMILES: CCCC1=C(C2=CC=C(O)C=C2)N(C3=CC=C(O)C=C3)N=C1C4=CC=C(O)C=C4
Biological Activity: Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%)[1][2].
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Propyl pyrazole triol | 99.11% | Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). | ||||||||||||||||||||
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Propyl pyrazole triol (Standard) | ≥98% | Propyl pyrazole triol (Standard) is the analytical standard of Propyl pyrazole triol. This product is intended for research and analytical applications. Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-W1006471Estrogen receptor-agonist-1 -
Similarity Score 0.68
HY-127133Methylpiperidino pyrazole -
Similarity Score 0.68
HY-103454BMPP hydrochloride -
Similarity Score 0.67
HY-103454RMPP dihydrochloride (Standard) -
Similarity Score 0.61
HY-179474TSI-13-57 -
Similarity Score 0.61
HY-143253Estrogen receptor antagonist 7 -
Similarity Score 0.54
HY-143267Estrogen receptor antagonist 8 -
Similarity Score 0.52
HY-151618Antitumor agent-79 -
Similarity Score 0.51
HY-183078P6620 -
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References
- [1]. Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells. [Content Brief]
- [2]. Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 2000 Dec 28;43(26):4934-47. [Content Brief]
