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Cat. No.: HY-143267

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Estrogen receptor antagonist 8

Name: Estrogen receptor antagonist 8
Brand: MedChemExpress
SKU: HY-143267
Price: 545.00 USD
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Estrogen receptor antagonist 8 is a potent ER-antagonist with in vivo anti-uterotrophic potential (EC50 = 4.160 μM).

For research use only. We do not sell to patients.

CAS No.: 2889370-92-5
Formula: C₂₅H₂₁N₃O₄
Molecular Weight:427.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Estrogen receptor antagonist 8 Chemical Structure

CAS No.: 2889370-92-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Estrogen receptor antagonist 8 is a potent ER-antagonist with in vivo anti-uterotrophic potential (EC50 = 4.160 μM).

IC₅₀ & Target^[1]

Estrogen receptor

All Estrogen Receptor/ERR Isoforms :

In Vivo

In an in vivo anti-uterotrophic assay, a dose-response curve set by measuring the reduction of uterus weight of immature female rats when compared to the control group.
Anti-uterotrophic assay of ER-antagonist (compound 4) (s.c.; 1, 3, 10, 20, 30 mg/Kg/day; 3 days) exhibits an excelled anti-uterotrophic potential than TMX (EC₅₀: 7.625 μM), the EC₅₀ value of ER-antagonist 8 is 4.160 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2889370-92-5
Molecular Weight 427.45
Formula C₂₅H₂₁N₃O₄
SMILES

COC(C=C1)=CC(CCC2=C3C4=CC=C(C=C4)OC)=C1C2=NN3C5=CC=C([N+]([O-])=O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mahmoud A Ragab, et al. Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity. Bioorg Chem. 2022 Feb;119:105554. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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Estrogen receptor antagonist 8

All Estrogen Receptor/ERR Isoforms