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  2. Estrogen Receptor/ERR
  3. Propyl pyrazole triol

Propyl pyrazole triol (Synonyms: PPT)

Cat. No.: HY-100689 Purity: >99.0%
Handling Instructions

Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).

For research use only. We do not sell to patients.

Propyl pyrazole triol Chemical Structure

Propyl pyrazole triol Chemical Structure

CAS No. : 263717-53-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%)[1].

IC50 & Target

Estrogen receptor alpha[1]

In Vitro

The EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM in ERα-U2OS-Luc cells[1].

Clinical Trial
Molecular Weight

386.44

Formula

C₂₄H₂₂N₂O₃

CAS No.

263717-53-9

SMILES

CCCC1=C(C2=CC=C(O)C=C2)N(C3=CC=C(O)C=C3)N=C1C4=CC=C(O)C=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (258.77 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5877 mL 12.9386 mL 25.8772 mL
5 mM 0.5175 mL 2.5877 mL 5.1754 mL
10 mM 0.2588 mL 1.2939 mL 2.5877 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 10 mg/mL (25.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 10 mg/mL (25.88 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 10 mg/mL (25.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Product Name:
Propyl pyrazole triol
Cat. No.:
HY-100689
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