TSI-13-57
Based on 1 Customer Validation
TSI-13-57 is a pan-TLR inhibitor (IC50: 2.7 μM, 6.03 μM, 7.37 μM, 6.38 μM for TLR9, TLR7, TLR2, TLR4, respectively). TSI-13-57 inhibits homodimerization of the TIR domains of MyD88. TSI-13-57 reduces systemic inflammatory responses in LPS-induced mice.
For research use only. We do not sell to patients.
- Purity: 98.73%
- CAS No.: 2257427-45-3
- Formula: C28H29N3O3
- Molecular Weight:455.55
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR9 2.7 μM (IC50) |
TLR7 6.03 μM (IC50) |
TLR2 7.37 μM (IC50) |
TLR4 6.38 μM (IC50) |
Chemical Information
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CAS No. 2257427-45-3
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Appearance Solid
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Molecular Weight 455.55
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Formula C28H29N3O3
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Color White to light brown
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SMILES
OC1=CC=C(C2=CC(C3=CC=C(OCCN4CCCCC4)C=C3)=NN2C5=CC=C(C=C5)O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (109.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen L, et al. Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling. J Med Chem. 2020 Nov 25;63(22):13316-13329. [Content Brief]
[2]. Ippagunta SK, et al. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Sci Signal. 2018 Aug 14;11(543):eaaq1077. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1951 mL | 10.9757 mL | 21.9515 mL | 54.8787 mL |
| 5 mM | 0.4390 mL | 2.1951 mL | 4.3903 mL | 10.9757 mL | |
| 10 mM | 0.2195 mL | 1.0976 mL | 2.1951 mL | 5.4879 mL | |
| 15 mM | 0.1463 mL | 0.7317 mL | 1.4634 mL | 3.6586 mL | |
| 20 mM | 0.1098 mL | 0.5488 mL | 1.0976 mL | 2.7439 mL | |
| 25 mM | 0.0878 mL | 0.4390 mL | 0.8781 mL | 2.1951 mL | |
| 30 mM | 0.0732 mL | 0.3659 mL | 0.7317 mL | 1.8293 mL | |
| 40 mM | 0.0549 mL | 0.2744 mL | 0.5488 mL | 1.3720 mL | |
| 50 mM | 0.0439 mL | 0.2195 mL | 0.4390 mL | 1.0976 mL | |
| 60 mM | 0.0366 mL | 0.1829 mL | 0.3659 mL | 0.9146 mL | |
| 80 mM | 0.0274 mL | 0.1372 mL | 0.2744 mL | 0.6860 mL | |
| 100 mM | 0.0220 mL | 0.1098 mL | 0.2195 mL | 0.5488 mL |
TSI-13-57 Related Classifications
HY-179474 Related Classifications
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