2257427-45-3
2257427-45-3
Chemical Structure
TSI-13-57
- CAS 番号: 2257427-45-3
- Formula:C28H29N3O3
- Molecular Weight:455.55
InChIKey: KSIJIGHGXBEURD-UHFFFAOYSA-N
SMILES: OC1=CC=C(C2=CC(C3=CC=C(OCCN4CCCCC4)C=C3)=NN2C5=CC=C(C=C5)O)C=C1
Biological Activity: TSI-13-57 is a pan-TLR inhibitor (IC50: 2.7 μM, 6.03 μM, 7.37 μM, 6.38 μM for TLR9, TLR7, TLR2, TLR4, respectively). TSI-13-57 inhibits homodimerization of the TIR domains of MyD88. TSI-13-57 reduces systemic inflammatory responses in LPS-induced mice[1][2].
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TSI-13-57 | 98.73% | TSI-13-57 is a pan-TLR inhibitor (IC50: 2.7 μM, 6.03 μM, 7.37 μM, 6.38 μM for TLR9, TLR7, TLR2, TLR4, respectively). TSI-13-57 inhibits homodimerization of the TIR domains of MyD88. TSI-13-57 reduces systemic inflammatory responses in LPS-induced mice. | ||||||||||||||||||||
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References
- [1]. Chen L, et al. Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling. J Med Chem. 2020 Nov 25;63(22):13316-13329. [Content Brief]
- [2]. Ippagunta SK, et al. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Sci Signal. 2018 Aug 14;11(543):eaaq1077. [Content Brief]
