1. Signaling Pathways
  2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR4 Isoform

TLR4

 
Cat. No. Product Name Effect Purity
  • HY-11109
    Resatorvid
    Inhibitor 99.95%
    Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor.
  • HY-D1056
    Lipopolysaccharides
    Activator
    Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria.
  • HY-N0774
    Isofraxidin
    Inhibitor 99.00%
    Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells.
  • HY-N0703
    Schaftoside
    Inhibitor 99.88%
    Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica.
  • HY-U00435
    Neoseptin 3
    Agonist 99.57%
    Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC50 of 18.5 μM.
  • HY-W082785A
    L6H21
    Inhibitor
    L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor.
  • HY-107352
    Fosfenopril
    Inhibitor
    Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor.
  • HY-124750
    NecroX-7
    Inhibitor
    NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor.
  • HY-125171
    IAXO-102
    Antagonist ≥98.0%
    IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling.
  • HY-N1346
    Robinin
    Inhibitor ≥98.0%
    Robinin is present in flavonoid fraction of Vigna unguiculata leaf.
  • HY-116213
    Sparstolonin B
    Antagonist 99.54%
    Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling.
  • HY-N6673
    Okanin
    Inhibitor 98.04%
    Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways.
  • HY-135042
    CAY10614
    Antagonist 98.04%
    CAY10614 is a potent TLR4 antagonist.
  • HY-130320
    Monophosphoryl lipid A
    Agonist
    Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist.
  • HY-126154
    L48H37
    Inhibitor
    L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability.
  • HY-N0392
    Polygalasaponin F
    Inhibitor 99.74%
    Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa).
  • HY-145245
    TLR4-IN-C34-C2-amide-C6-OH
    Inhibitor
    TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34.
  • HY-145255
    Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH
    Inhibitor
    Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34.
  • HY-N8277
    Kdo2-Lipid A ammonium
    Activator
    Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS.
  • HY-145253
    Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH
    Inhibitor
    Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34.
Cat. No. Product Name / Synonyms Species Source