1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Monophosphoryl lipid A

Monophosphoryl lipid A (Synonyms: Glucopyranosyl lipid A)

Cat. No.: HY-130320
Handling Instructions

Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine.

For research use only. We do not sell to patients.

Monophosphoryl lipid A Chemical Structure

Monophosphoryl lipid A Chemical Structure

CAS No. : 1246298-63-4

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Description

Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine[1].

IC50 & Target[1]

TLR4

 

In Vitro

Monophosphoryl lipid A (100 μg/ml, 2 hours; dendritic cells) induces NF-κB activation and modulates TLR2[2].
Monophosphoryl lipid A (5~100 μg/ml, 24 hours; dendritic cells) induces IL-12 production by human[2].
Increasing the amount of Monophosphoryl lipid A (from 0.1 to 1 μg), the percentage of matured BMDCs also increased[1]. Monophosphoryl lipid A up-regulates dendritic cells surface markers. Monophosphoryl lipid A enhances T cell responses. Monophosphoryl lipid A (CD4 T cells) increases calcium mobilization of activated T cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Dendritic cells
Concentration: 100 μg/ml
Incubation Time: 2 hours
Result: Induced NF-κB activation and modulated TLR2.
In Vivo

The generated Monophosphoryl lipid A has been shown to activate APC and to enhance the generation of both Th1- and Th2-specific immune response in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1763.47

Formula

C₉₆H₁₈₄N₃O₂₂P

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Monophosphoryl lipid A
Cat. No.:
HY-130320
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