1. Immunology/Inflammation
    Anti-infection
  2. Toll-like Receptor (TLR)
    HIV
  3. Sparstolonin B

Sparstolonin B 

Cat. No.: HY-116213
Handling Instructions

Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.

For research use only. We do not sell to patients.

Sparstolonin B Chemical Structure

Sparstolonin B Chemical Structure

CAS No. : 1259330-61-4

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Description

Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2].

IC50 & Target[1][2]

TLR2

 

TLR4

 

HIV-1

 

In Vitro

Sparstolonin B (1-20 µM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells[3].
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2[1].
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells[3].

Cell Viability Assay[3]

Cell Line: SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells
Concentration: 1 µM, 5 µM, 10 µM or 20 µM
Incubation Time: 2-4 days
Result: Effectively and dose-dependently inhibits the viability of all neuroblastoma cell lines after 2 days (SH-SY5Y and IMR-32), 3 days (NGP cells) or 4 days (SKNF-1 and SK-N-BE(2) cells) treatment.
In Vivo

Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice[1].

Animal Model: 5-6-week-old male C57Bl/6 mice (body weight 18-20 g)[1]
Dosage: 100 μg/mouse
Administration: I.p.
Result: Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.
Molecular Weight

268.22

Formula

C₁₅H₈O₅

CAS No.

1259330-61-4

SMILES

O=C1OC=C2C3=C(OC4=C2C1=C(O)C=C4)C=CC(O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Sparstolonin BToll-like Receptor (TLR)HIVHuman immunodeficiency virusvirusviabilityneuroblastomacellinflammationcytokineMyD88recruitmentInhibitorinhibitorinhibit

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Sparstolonin B
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