Sparstolonin B 

Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities^[1][2].

Sparstolonin B (1-20 µM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells^[3].
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2^[1].
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

268.22

Solid

C₁₅H₈O₅

1259330-61-4

O=C1OC=C2C3=C(OC4=C2C1=C(O)C=C4)C=CC(O)=C3

Room temperature in continental US; may vary elsewhere.

• [1]. Liang Q, et al. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011;286(30):26470-26479.  [Content Brief]

  [2]. Deng X, et al. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015;12:108. Published 2015 Jul 25.  [Content Brief]

  [3]. Kumar A, et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells [published correction appears in PLoS One. 2016;11(7):e0159082]. PLoS One. 2014;9(5):e96  [Content Brief]