Macrophage-activating lipopeptide 2 TFA
Based on 1 Customer Validation
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL).
For research use only. We do not sell to patients.
- Purity: 99.83%
- Formula: C99H167N19O30S.xC2HF3O2
- Molecular Weight:2135.56 (free base)
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) can promote the expression of major endothelial adhesion molecules and leukocyte integrin receptors, thereby enhancing leukocyte endothelial adhesion[1]. Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) can promote the phosphorylation of protein kinase B and eNOS in endothelial MyEnd cells, thereby promoting NO release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Solid
-
Molecular Weight 2135.56 (free base)
-
Formula C99H167N19O30S.xC2HF3O2
-
Color White to off-white
-
Synonyms
MALP-2 TFA
-
Sequence
{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys
-
Sequence Shortening
{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1.96 mg/mL (ultrasonic and adjust pH to 12 with 1 M NaOH)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Macrophage-activating lipopeptide 2 TFA Related Classifications
HY-P10586A Related Classifications
Powered by Bioz