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C29

110 Cited Publications
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Based on 110 publication(s) in Google Scholar

C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively.

For research use only. We do not sell to patients.

  • Purity: 98.0%
  • CAS No.: 363600-92-4
  • Formula: C16H15NO4
  • Molecular Weight:285.29
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • C29 Chemical Structure
    C29 Chemical Structure
  • Experimental Validation Results for C29
  • Experimental Validation Results for C29
  • Experimental Validation Results for C29
  • Experimental Validation Results for C29
  • Experimental Validation Results for C29
  • Experimental Validation Results for C29
  • Experimental Validation Results for C29
  • Experimental Validation Results for C29
CAS No.: 363600-92-4
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RT-PCRCell Migration/Invasion AssayWBIF
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  • C29 Chemical Structure
    C29 Chemical Structure
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    C29 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Aug 26;23(1):381. [Abstract]

    Customer Validation
     Neutrophils were pretreated with the TLR2 and TLR4 inhibitor Sparstolonin B (SsnB) (HY-116213; 10 µM), the TLR2 inhibitor C29 (HY-100461; 100 µM), or the TLR4 inhibitor C34 (TLR4-IN-C34; HY-107575; 10 µM) for 30 min before stimulation with calreticulin. Transwell migration assay. The lower chambers were loaded with blank culture medium (a), calreticulin (b), calreticulin with SsnB (c), calreticulin with C29 (d), or calreticulin with C34 (e). CFSE-labeled neutrophils were loaded into the upper chamber and allowed to migrate for 3 h.

  • 1/16

    C29 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Apr 11;23(1):181. [Abstract]

    Customer Validation
     BMDMs were pretreated with a TLR2 inhibitor (C29; HY-100461; 10 µM), TLR4 inhibitor (TAK242; HY-11109; 10 µM), TLR7 inhibitor (IRS661, 1 µM), TLR8 inhibitor (CU-CPT9a; HY-112667; 10 µM), or TLR9 inhibitor (IRS869, 1 µM) for 1 h, and then treated with NETs (500 ng/mL) for 3 h. The levels of Il1b, Il6 were measured by qPCR (n = 6).

  • 1/16

    C29 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Aug 26;23(1):381. [Abstract]

    Customer Validation
     Neutrophils were pretreated with the TLR2 and TLR4 inhibitor Sparstolonin B (SsnB) (HY-116213; 10 µM), the TLR2 inhibitor C29 (HY-100461; 100 µM), or the TLR4 inhibitor C34 (TLR4-IN-C34; HY-107575; 10 µM) for 30 min before stimulation with calreticulin. F-actin was detected for 30 min the incubation of neutrophils with calreticulin in the presence of the respective inhibitors (scale bars = 10 μm).

  • 1/16

    C29 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Apr 11;23(1):181. [Abstract]

    Customer Validation
     BMDMs were pretreated with a TLR2 inhibitor (C29; HY-100461; 10 µM), TLR4 inhibitor (TAK242; HY-11109; 10 µM), TLR7 inhibitor (IRS661, 1 µM), TLR8 inhibitor (CU-CPT9a; HY-112667; 10 µM), or TLR9 inhibitor (IRS869, 1 µM) for 1 h, and then treated with NETs (500 ng/mL) for 3 h. The level of Tnfa mRNA was measured by qPCR (n = 6).

  • 1/16

    C29 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Aug 26;23(1):381. [Abstract]

    Customer Validation
     Neutrophils were incubated in calreticulin with or without inhibitors of TLR2/TLR4 (SsnB; HY-116213; 10 µM), TLR2 (C29; HY-100461; 100 µM), or TLR4 (C34; TLR4-IN-C34; HY-107575; 10 µM) for 0 min, 1 min, 3 min, or 5 min. The cell lysate was prepared and subjected to western blotting for analysis of the expression of Cdc42, Rac1, and RhoA. Densitometric analysis of each protein band is shown below the blots, representing grayscale quantification relative to internal controls

  • 1/16

    C29 purchased from MedChemExpress. Usage Cited in: J Control Release. 2020 Dec 10;328:210-221. [Abstract]

    Customer Validation
     Western blot analysis show that MyD88 is active in DP7-C-stimulated BMDCs, and the activation of MyD88 expression by DP7-C and DOTAP/DP7-C is inhibited after BMDCs are pretreated with C29.

  • 1/16

    C29 purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2018 Nov 1:686:33-40. [Abstract]

    Customer Validation
     Western Blot analyses show the protein expression of MCPIP1 after the treatment of PBS and LPS (with TAK-242, C29, FPS-ZM1).

  • 1/16

    C29 purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2018 Nov 1:686:33-40. [Abstract]

    Customer Validation
     Images show the expression of MCPIP1 after the treatment of of PBS and LPS (with TAK-242, C29, FPS-ZM1).

  • C29