1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. TLR4-IN-C34

TLR4-IN-C34 

Cat. No.: HY-107575
Handling Instructions

TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.

For research use only. We do not sell to patients.

TLR4-IN-C34 Chemical Structure

TLR4-IN-C34 Chemical Structure

CAS No. : 40592-88-9

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Description

TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2].

In Vivo

TLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa[1].

Animal Model: Experimental NEC induced in 7-8 day old mice[1].
Dosage: 1 mg/kg.
Administration: Orally every morning.
Result: Attenuated intestinal inflammation.
Molecular Weight

389.40

Formula

C₁₇H₂₇NO₉

CAS No.

40592-88-9

SMILES

O=C(N[[email protected]]([[email protected]@H](OC(C)=O)[[email protected]](OC(C)=O)[[email protected]@H](COC(C)=O)O1)[[email protected]]1OC(C)C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TLR4-IN-C34Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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