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TLR4-IN-C34

14 Cited Publications
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Based on 14 publication(s) in Google Scholar

TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.

For research use only. We do not sell to patients.

  • Purity: 99.94%
  • CAS No.: 40592-88-9
  • Formula: C17H27NO9
  • Molecular Weight:389.40
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • TLR4-IN-C34 Chemical Structure
    TLR4-IN-C34 Chemical Structure
  • Experimental Validation Results for TLR4-IN-C34
  • Experimental Validation Results for TLR4-IN-C34
  • Experimental Validation Results for TLR4-IN-C34
  • Experimental Validation Results for TLR4-IN-C34
  • Experimental Validation Results for TLR4-IN-C34
  • Experimental Validation Results for TLR4-IN-C34
CAS No.: 40592-88-9
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In Vivo Efficacy StudyCell Migration/Invasion AssayWBCell Imaging/Staining
  • In Vivo Efficacy Study
  • Cell Migration/Invasion Assay
  • Cell Migration/Invasion Assay
  • WB
  • WB
  • Cell Imaging/Staining

All Toll-like Receptor (TLR) Isoforms

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  • TLR4-IN-C34 Chemical Structure
    TLR4-IN-C34 Chemical Structure
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    TLR4-IN-C34 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2471015. [Abstract]

    Customer Validation
     TLR4-IN-C34 ( orally; 1 mg/kg daily from the 7th postnatal day to the 3rd day after HI insult) treatment improved intestinal dysfunction and alleviated synaptic and cognitive impairments in the neonatal HIBD rats. The expression levels of TLR4 of colon by WB and IF analyses.

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    TLR4-IN-C34 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Aug 26;23(1):381. [Abstract]

    Customer Validation
     Neutrophils were pretreated with the TLR2 and TLR4 inhibitor Sparstolonin B (SsnB) (HY-116213; 10 µM), the TLR2 inhibitor C29 (HY-100461; 100 µM), or the TLR4 inhibitor C34 (TLR4-IN-C34; HY-107575; 10 µM) for 30 min before stimulation with calreticulin. Transwell migration assay. The lower chambers were loaded with blank culture medium (a), calreticulin (b), calreticulin with SsnB (c), calreticulin with C29 (d), or calreticulin with C34 (e). CFSE-labeled neutrophils were loaded into the upper chamber and allowed to migrate for 3 h.

  • 1/16

    TLR4-IN-C34 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Aug 26;23(1):381. [Abstract]

    Customer Validation
     Neutrophils were pretreated with the TLR2 and TLR4 inhibitor Sparstolonin B (SsnB) (HY-116213; 10 µM), the TLR2 inhibitor C29 (HY-100461; 100 µM), or the TLR4 inhibitor C34 (TLR4-IN-C34; HY-107575; 10 µM) for 30 min before stimulation with calreticulin. F-actin was detected for 30 min the incubation of neutrophils with calreticulin in the presence of the respective inhibitors (scale bars = 10 μm).

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    TLR4-IN-C34 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Aug 26;23(1):381. [Abstract]

    Customer Validation
     Neutrophils were incubated in calreticulin with or without inhibitors of TLR2/TLR4 (SsnB; HY-116213; 10 µM), TLR2 (C29; HY-100461; 100 µM), or TLR4 (C34; TLR4-IN-C34; HY-107575; 10 µM) for 0 min, 1 min, 3 min, or 5 min. The cell lysate was prepared and subjected to western blotting for analysis of the expression of Cdc42, Rac1, and RhoA. Densitometric analysis of each protein band is shown below the blots, representing grayscale quantification relative to internal controls

  • 1/16

    TLR4-IN-C34 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 May 1;21(1):86. [Abstract]

    Customer Validation
     Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2 (HY-112146; MMG-11), TLR4 (HY-107575; TLR4-IN-C34 ), TLR9 (HY-131952; TLR7/8/9-IN-1) and RAGE (HY-P2268; RAGE antagonist peptide) for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting.

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    TLR4-IN-C34 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 May 1;21(1):86. [Abstract]

    Customer Validation
     Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2 (HY-112146; MMG-11), TLR4 (HY-107575; TLR4-IN-C34 ), TLR9 (HY-131952; TLR7/8/9-IN-1) and RAGE (HY-P2268; RAGE antagonist peptide) for 1 h prior to coculture with hypoxic-CM from GC cells, and the NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, **P < 0.01

  • TLR4-IN-C34