40592-88-9
40592-88-9
Chemical Structure
TLR4-IN-C34
- CAS No.: 40592-88-9
- Formula:C17H27NO9
- Molecular Weight:389.40
IUPAC Name: (2R,3S,4R,5R,6S)-5-acetamido-2-(acetoxymethyl)-6-isopropoxytetrahydro-2H-pyran-3,4-diyl diacetate
InChIKey: KMIQMFHPUJUDMC-HHARLNAUSA-N
SMILES: O=C(N[C@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)[C@H]1OC(C)C)C
Biological Activity: TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2].
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TLR4-IN-C34 | 99.94% | TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis. | ||||||||||||||||||||
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TLR4-IN-C34 (Standard) | TLR4-IN-C34 (Standard) is the analytical standard of TLR4-IN-C34 (HY-107575). This product is intended for research and analytical applications. TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis. | |||||||||||||||||||||
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References
- [1]. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779. [Content Brief]
- [2]. Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100. [Content Brief]
