1. Immunology/Inflammation
    Anti-infection
  2. Toll-like Receptor (TLR)
    Bacterial
  3. TH1020

TH1020 

Cat. No.: HY-116961 Purity: 99.69%
Handling Instructions

TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 μM. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8.

For research use only. We do not sell to patients.

TH1020 Chemical Structure

TH1020 Chemical Structure

CAS No. : 1841460-82-9

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Based on 1 publication(s) in Google Scholar

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Description

TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 μM. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8[1].

IC50 & Target

IC50: 0.85 μM (toll-like receptor 5 (TLR5)/flagellin complex)[1]

In Vitro

TH1020 inhibits the downstream signaling transduction mediated by the formation of the TLR5/Flagellin complex. TH1020 is suggested to compete with flagellin and disrupt its association with TLR5. TH1020 almost completely abolishes the TLR5-mediated TNF-α secretion at 0.37 μM[1].
The IL-17C secretion is almost completely abolished by TH1020 (0.5 μM) in bacterial strain C83901 infected IPEC-J2 cells[2].
Blocking TLR5 with TH1020 (0.5 μM) dramatically inhibits porcine beta-defensin (pBD)-2, claudin-1 and -2 mRNA expression in C83091 infected IPEC-J2 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

453.54

Formula

C₂₃H₁₅N₇S₂

CAS No.

1841460-82-9

SMILES

C12=NC=NC(SC3=NN=C(N3CC4=CC=CC=C4)C5=CC=NC=C5)=C1SC6=NC=CC=C62

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (4.41 mM; ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2049 mL 11.0244 mL 22.0488 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

TH1020TH 1020TH-1020Toll-like Receptor (TLR)BacterialTLR5flagellinprotein-proteininteractionTNF-αInhibitorinhibitorinhibit

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TH1020
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