Macrophage-activating lipopeptide 2
Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL).
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- CAS No.: 250718-44-6
- Formula: C99H167N19O30S
- Molecular Weight:2135.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR2 |
TLR6 |
Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) can promote the expression of major endothelial adhesion molecules and leukocyte integrin receptors, thereby enhancing leukocyte endothelial adhesion[1]. Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) can promote the phosphorylation of protein kinase B and eNOS in endothelial MyEnd cells, thereby promoting NO release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Endothelial MyEnd cells
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Concentration:1 µg/mL
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Incubation Time:24 h
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Result:Caused a strong transient increase in mRNA levels of vascular cell adhesion molecule-1 (Vcam-1) after 1 hour, and also increased the levels of other major endothelial adhesion molecules, namely intercellular adhesion molecule-1 (Icam-1), E-selectin, and P-selectin, between 1-3 hours.
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Cell Line:Endothelial MyEnd cells
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Concentration:1 µg/mL
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Incubation Time:2 h
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Result:Promoted phosphorylation of protein kinase B and eNOS.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-10 weeks old male C57BL/6 Hypercholesterolemic Apoe-deficient mice[1].
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Dosage:1 µg in 125 µL PBS
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Administration:Intravenous injection (i.v.); once daily; 10 days
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Result:Improved blood flow recovery and increased the growth of pre-existing collateral arteries in the upper and hind limbs, as well as the proliferation of endothelial cells and accumulation of peri collagenous macrophages in the collateral walls.
Chemical Information
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CAS No. 250718-44-6
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Molecular Weight 2135.56
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Formula C99H167N19O30S
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Synonyms
MALP-2
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Sequence
{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys
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Sequence Shortening
{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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