The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription

  • Virol J. 2015 Jul 25;12:108. doi: 10.1186/s12985-015-0339-8.
Xin Deng  1 ,  Yaping Zhang  2 ,  Feng Jiang  3 ,  Ran Chen  4 ,  Peichun Peng  5 ,  Bin Wen  6 ,  Jian Liang  7
Affiliations
  • 1. Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 2. Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 3. Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 4. Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 5. Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 6. Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 7. Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
PMID: 26206295 DOI: 10.1186/s12985-015-0339-8
Abstract

Background: The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV Infection.

Findings: We found that SsnB treatment blocked HIV-1 transcription via a novel mechanism that requires the TAR region. Treatment of human T cell lines or peripheral blood mononuclear cells with SsnB at 1 μM significantly inhibited HIV production. Lastly, SsnB was able to inhibit HIV in synergy with AZT.

Conclusions: These data suggest that SsnB is a novel natural compound that inhibits HIV-1 transcription and may be a new drug in the treatment of HIV Infection.

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