1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. MMG-11

MMG-11 

Cat. No.: HY-112146
Handling Instructions

MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses.

For research use only. We do not sell to patients.

MMG-11 Chemical Structure

MMG-11 Chemical Structure

CAS No. : 313254-94-3

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Description

MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses[1].

IC50 & Target

TLR2

 

In Vitro

MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 µM) shows no cytotoxic effects up to 100 µM in peripheral blood mononuclear cells (PBMCs)[1] .

Cell Cytotoxicity Assay[1]

Cell Line: PBMCs
Concentration: 0.01, 1, 10, 100 µM
Incubation Time:
Result: Showed no cytotoxic effects up to 100 µM.
Molecular Weight

306.27

Formula

C₁₅H₁₄O₇

CAS No.

313254-94-3

SMILES

OC1=C(O)C(O)=C(C(CC2=CC=C(C(OCC)=O)O2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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